Results 121 to 130 of about 654,837 (328)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Clinical and Experimental Gastroenterology, 2020 Sachin Mohan,1– 3 Shaffer Mok,4 Thomas Judge5 1Department of Gastroenterology and Hepatology, University of Minnesota School of Medicine, St Paul, MN, USA; 2Regions Hospital, Department of Gastroenterology and Hepatology, St Paul, MN, USA; 3Health ...
Mohan S, Mok S, Judge T
doaj
Pathway-Based Drug Repositioning for Breast Cancer Molecular Subtypes
Frontiers in Pharmacology, 2018 Breast cancer is a major public health problem which treatment needs new pharmacological options. In the last decades, during the postgenomic era new theoretical and technological tools that give us novel and promising ways to address these problems have
Raúl A. Mejía-Pedroza +4 more
doaj +1 more source
Using a Big Data Database to Identify Pathogens in Protein Data Space [PDF]
arXiv, 2015 Current metagenomic analysis algorithms require significant computing resources, can report excessive false positives (type I errors), may miss organisms (type II errors / false negatives), or scale poorly on large datasets. This paper explores using big data database technologies to characterize very large metagenomic DNA sequences in protein space ...
arxiv
Genetic Programming for Multibiometrics
, 2012 Biometric systems suffer from some drawbacks: a biometric system can provide in general good performances except with some individuals as its performance depends highly on the quality of the capture. One solution to solve some of these problems is to use
Giot, Romain, Rosenberger, Christophe
core +3 more sources
The Genetic Association Database [PDF]
Nature Genetics, 2004 Kathleen C. Barnes +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Bioethics, Complementarity, and Corporate Criminal Liability [PDF]
, 2017 This article provides a brief introduction to some contemporary challenges found in the intersection of bioethics and international criminal law involving genetic privacy, organ trafficking, genetic engineering, and cloning.
Long, Ryan
core
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
A core genetic module : the Mixed Feedback Loop
, 2005 The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer.
B. Alberts +9 more
core +1 more source