Results 151 to 160 of about 5,302,158 (304)

Genetic databases and donor anonymity [PDF]

Human Reproduction, 2019
Kennett, D, Reisel, D, Harper, J
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Retrieval accuracy of very large DNA-Based databases of digital signals

, 2007
In this paper a simulation of single query searches in very large DNA-based databases that are capable of storing and retrieving digital signals is presented.
Tsaftaris, Sotirios A., Katsaggelos, Aggelos K.   +1 more
core  

GENETIC DATABASES AND PUBLIC ATTITUDES: A COMPARISON OF ICELAND, ESTONIA AND THE UK [PDF]

Trames, 2004
Külliki Korts, Sue Weldon, Margrét Lilja Guðmundsdóttir   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evolving Takagi-Sugeno-Kang fuzzy systems using multi-population grammar guided genetic programming

This work proposes a novel approach for the automatic generation and tuning of complete Takagi-Sugeno-Kang fuzzy rule based systems. The examined system aims to explore the effects of a reduced search space for a genetic programming framework by means of
Tsakonas, Athanasios, Gabrys, Bogdan
core  

A Weighted Sum Validity Function for Clustering with a Hybrid Niching Genetic Algorithm

, 2005
Clustering is inherently a difficult problem, both with respect to the construction of adequate objective functions as well as to the optimization of the objective functions.
Liu, X, Zhang, Leishi, Weiguo Sheng, Stephen Swift, Xiaohui Liu, Zhang, L, Sheng, Weiguo, Sheng, W, Swift, S, Swift, S., Leishi Zhang, Liu, Xiaohui   +11 more
core   +1 more source

The Ethics and Governance of Human Genetic Databases: European Perspectives

SCRIPTed: A Journal of Law, Technology & Society, 2008
Adrienne Hunt
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source