Results 41 to 50 of about 373,528 (267)

INFORMATIONAL RESOURCES ON POTATO GERMPLASM COLLECTIONS

Вавиловский журнал генетики и селекции, 2018
The potato (Solanum tuberosum L.) is one of the most important food crops, the advantage of which is the ability to give a high yield in a wide range of agroecosystems, high specific production of dry weight per unit of cultivated area.
D. A. Afonnikov, I. V. Totsky, Z. Stasevski   +2 more
doaj   +1 more source

Calibration of the empirical fundamental relationship using very large databases

Transportes, 2021
This paper describes a procedure for fitting traffic stream models using very large traffic databases. The proposed approach consists of four steps: (1) an initial treatment to eliminate noisy, inaccurate data and to homogenize the information over the ...
Juliana Mitsuyama Cardoso, Lucas Assirati, José Reynaldo Setti   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

Nature Communications, 2016
Current databases of V genes for antibody repertoire have limitations. Here Corcoran et al. develop a computational approach named IgDiscover that can identify germline V gene sequences from expressed antibody repertoires to high specificity and ...
Martin M. Corcoran, Ganesh E. Phad, Néstor Vázquez Bernat, Christiane Stahl-Hennig, Noriyuki Sumida, Mats A.A. Persson, Marcel Martin, Gunilla B. Karlsson Hedestam   +7 more
doaj   +1 more source

Screening and biological function analysis of differentially expressed genes associated with miR-21 in hepatocellular carcinoma tissue [PDF]

精准医学杂志
Objective To investigate the differentially expressed genes (DEGs) associated with miR-21 between hepatocellular carcinoma (HCC) tissue and normal tissue, as well as their biological function in the development and progression of HCC.
SUN Chenggong, TIAN Ying, JIANG Feng
doaj   +1 more source

Human genetic variation database, a reference database of genetic variations in the Japanese population [PDF]

Journal of Human Genetics, 2016
Whole-genome and -exome resequencing using next-generation sequencers is a powerful approach for identifying genomic variations that are associated with diseases. However, systematic strategies for prioritizing causative variants from many candidates to explain the disease phenotype are still far from being established, because the population-specific ...
Higasa, Koichiro, Miyake, Noriko, Yoshimura, Jun, Okamura, Kohji, Niihori, Tetsuya, Saitsu, Hirotomo, Doi, Koichiro, Shimizu, Masakazu, Nakabayashi, Kazuhiko, Aoki, Yoko, Tsurusaki, Yoshinori, Morishita, Shinichi, Kawaguchi, Takahisa, Migita, Osuke, Nakayama, Keiko, Nakashima, Mitsuko, Mitsui, Jun, Narahara, Maiko, Hayashi, Keiko, Funayama, Ryo, Yamaguchi, Daisuke, Ishiura, Hiroyuki, Ko, Wen-Ya, Hata, Kenichiro, Nagashima, Takeshi, Yamada, Ryo, Matsubara, Yoichi, Umezawa, Akihiro, Tsuji, Shoji, Matsumoto, Naomichi, Matsuda, Fumihiko   +30 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

OryGenesDB: a database for rice reverse genetics [PDF]

Nucleic Acids Research, 2006
Insertional mutant databases containing Flanking Sequence Tags (FSTs) are becoming key resources for plant functional genomics. We have developed OryGenesDB (http://orygenesdb.cirad.fr/), a database dedicated to rice reverse genetics. Insertion mutants of rice genes are catalogued by Flanking Sequence Tag (FST) information that can be readily accessed ...
Droc, Gaëtan, Ruiz, Manuel, Larmande, Pierre, Pereira, Andy, Piffanelli, Pietro, Morel, Jean-Benoit, Dievart, Anne, Courtois, Brigitte, Guiderdoni, Emmanuel, Perin, Christophe, Centre de Coopération Internationale en Recherche Agronomique pour le Développement   +10 more
openaire   +7 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A scoping review of human genetic resources management policies and databases in high- and middle-low-income countries

BMC Medical Ethics
Background This review examines global human genetic resources management, focusing on genetic data policies and repositories in high- and middle-low-income countries.
Hongwei Liu, Yin Liu, Yanyan Zhao, Yingqi Ma, Qiong Chen, Huifang Xu, Xiaoyang Wang, Xiaoli Guo, Hong Wang, Zelong Chen, Shaokai Zhang, Binbin Han   +11 more
doaj   +1 more source