Results 61 to 70 of about 5,302,158 (304)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Prototyping a genetics deductive database.
Proceedings. International Conference on Intelligent Systems for Molecular Biology, 1994 We are developing a laboratory notebook system known as the Genetics Deductive Database. Currently our prototype provides storage for biological facts and rules with flexible access via an interactive graphical display. We have introduced a formal basis for the representation and reasoning necessary to order genome map data and handle the uncertainty ...
C. Hearne +3 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Genetic programming for knowledge discovery in chest pain diagnosis [PDF]
, 2000 This work aims at discovering classification rules for diagnosing certain pathologies. These rules are capable of discriminating among 12 different pathologies, whose main symptom is chest pain.
Bojarczuk, Celia C. +5 more
core +1 more source
Subquery allocations in distributed databases using genetic algorithms
Journal of Computer Science and Technology, 2010 Minimization of query execution time is an important performance objective in distributed databases design. While total time is to be minimized for On Line Transaction Processing (OLTP) type queries, response time has to be minimized in Decision Support ...
Narasimhaiah Gorla, Suk-Kyu Song
doaj
BiologyWhy should a genome be protected? Because it contains our most private data! A genome contains an organism’s set of genetic material (DNA and, in viruses, RNA), and it contains all genes and non-coding sequences.
Marlena Szalata +3 more
doaj +1 more source
Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases.
Journal of Clinical Investigation, 2019 Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD.
R. Cai +18 more
semanticscholar +1 more source
Indigenous Genomic Databases: Pragmatic Considerations and Cultural Contexts
Frontiers in Public Health, 2020 The potential to grow genomic knowledge and harness the subsequent clinical benefits has escalated the building of background variant databases (BVDs) for genetic diagnosis across the globe.
N. Caron +7 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Genetic Diversity and Mutation Frequency Databases in Ethnic Populations: Systematic Review
JMIR Bioinformatics and BiotechnologyBackgroundNational and ethnic mutation frequency databases (NEMDBs) play a crucial role in documenting gene variations across populations, offering invaluable insights for gene mutation research and the advancement of precision medicine.
Shumaila Khan +8 more
doaj +1 more source