Results 41 to 50 of about 5,302,158 (304)

The art of curation at a biological database: Principles and application

Current Plant Biology, 2017
The variety and quantity of data being produced by biological research has grown dramatically in recent years, resulting in an expansion of our understanding of biological systems. However, this abundance of data has brought new challenges, especially in
Sarah G. Odell, Gerard R. Lazo, Margaret R. Woodhouse, David L. Hane, Taner Z. Sen   +4 more
doaj   +1 more source

GSD: a genetic screen database

Mechanisms of Development, 2004
The systematic assignment of gene function to a sequenced genome is one of the outstanding challenges in the post-genomic era. Large-scale systematic mutagenesis screens are important tools for reaching this goal. Here we describe GSD, a software package that allows storage and integration of data from genetic screens. GSD was initially developed for a
Henrich, Thorsten, Ramialison, Mirana, Segerdell, Erik, Westerfield, Monte, Furutani-Seiki, Makoto, Wittbrodt, Joachim, Kondoh, Hisato   +6 more
openaire   +2 more sources

Public participation in genetic databases: crossing the boundaries between biobanks and forensic DNA databases through the principle of solidarity

Journal of Medical Ethics, 2015
The ethical aspects of biobanks and forensic DNA databases are often treated as separate issues. As a reflection of this, public participation, or the involvement of citizens in genetic databases, has been approached differently in the fields of ...
H. Machado, Susana Silva
semanticscholar   +1 more source

Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases

npj Genomic Medicine, 2023
Von Willebrand disease (VWD) is a common bleeding disorder caused by mutations in the von Willebrand factor gene (VWF). The true global prevalence of VWD has not been accurately established.
Omid Seidizadeh, Andrea Cairo, Luciano Baronciani, Luca Valenti, Flora Peyvandi   +4 more
doaj   +1 more source

326 Integrated Analysis of Genetic Databases Identifies miRNA Associated With Poor Survival In Melanoma

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: Despite advances in precision medicine and understanding of the molecular pathways, melanoma remains the deadliest skin cancer, warranting identification of novel biomarkers.
Reid McCallister, Chitra Subramanian, Nikhil Mantena, Mark Cohen   +3 more
doaj   +1 more source

Human Ageing Genomic Resources: new and updated databases

Nucleic Acids Res., 2017
In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ...
Robi Tacutu, Daniel Thornton, Emily Johnson, A. Budovsky, Diogo Barardo, Thomas Craig, E. Diana, Gilad Lehmann, Dmitri Toren, Jingwei Wang, V. Fraifeld, J. P. D. Magalhães   +11 more
semanticscholar   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Estimation of ENPP1 deficiency genetic prevalence using a comprehensive literature review and population databases

Orphanet Journal of Rare Diseases, 2022
Background ENPP1 Deficiency—caused by biallelic variants in ENPP1—leads to widespread arterial calcification in early life (Generalized Arterial Calcification of Infancy, GACI) or hypophosphatemic rickets in later life (Autosomal Recessive ...
Lauren M. Chunn, Jeffrey Bissonnette, Stefanie V. Heinrich, Stephanie A. Mercurio, Mark J. Kiel, Frank Rutsch, Carlos R. Ferreira   +6 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Nutrigenomics, individualism and public health. [PDF]

, 2004
Issues arising in connection with genes and nutrition policy include both nutrigenomics and nutrigenetics. Nutrigenomics considers the relationship between specifc nutrients or diet and gene expression and, it is envisaged, will facilitate prevention of ...
Chadwick, Ruth
core   +1 more source