Results 61 to 70 of about 654,837 (328)
Predicting Defects in Software Using Grammar-Guided Genetic Programming [PDF]
, 2008 The knowledge of the software quality can allow an organization to allocate the needed resources for the code maintenance. Maintaining the software is considered as a high cost factor for most organizations. Consequently, there is need to assess software
Dounias, Georgios, Tsakonas, Athanasios
core +2 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Lifetime risk of autosomal recessive mitochondrial disorders calculated from genetic databases
EBioMedicine, 2020 Background: Mitochondrial disorders are a group of rare diseases, caused by nuclear or mitochondrial DNA mutations. Their marked clinical and genetic heterogeneity as well as referral and ascertainment biases render phenotype-based prevalence estimations
Jing Tan +8 more
doaj
Public participation in genetic databases [PDF]
European Journal of Public Health, 2014 Background The ethical aspects of biobanks and forensic DNA databases are very commonly treated as separate issues. As a reflection of this, public participation, or the involvement of citizens in genetic databases, has been approached differently in the fields of forensics and medicine.
Susana Silva, Helena Machado
openaire +2 more sources
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
The Regulation of Human Genetic Databases in Japan
SCRIPTed: A Journal of Law, Technology & Society, 2004 Regulators drafting the legal and ethical framework of the UK Biobank Project are attempting to achieve a complex and delicate balance of interests. The regulatory structure which they devise must maximise the usefulness of the Biobank as a long-term ...
Gerard Porter
doaj
GEMINI: integrative exploration of genetic variation and genome annotations [PDF]
, 2013 Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable challenge for medical genetics. We have developed GEMINI (GEnome MINIng), a flexible software package for exploring all forms of human ...
arxiv +1 more source
An Ontology Based Method to Solve Query Identifier Heterogeneity in Post-Genomic Clinical Trials [PDF]
, 2008 The increasing amount of information available for biomedical research has led to issues related to knowledge discovery in large collections of data. Moreover, Information Retrieval techniques must consider heterogeneities present in databases, initially
Anguita Sanchez, Alberto +3 more
core +1 more source
Automated data integration for developmental biological research [PDF]
, 2007 In an era exploding with genome-scale data, a major challenge for developmental biologists is how to extract significant clues from these publicly available data to benefit our studies of individual genes, and how to use them to improve our understanding
Sternberg, Paul W., Zhong, Weiwei
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source