Results 91 to 100 of about 3,306,534 (272)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database [PDF]

, 2016
Babak Mokhlesi, Sandra A. Ham, David Gozal   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

FARGO: Feature-Augmented Representation Learning Combined With Enhanced GraphSAGE for Community Detection

IEEE Access
Community detection in complex networks remains a fundamental challenge across the social, biological, and technological domains. This paper presents FARGO, a graph neural network framework that unifies topological feature engineering, inductive learning,
Lyazid Toumi, Yacine Slimani, Ahmet Ugur
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

ForC: a global database of forest carbon stocks and fluxes [PDF]

, 2018
Kristina J. Anderson‐Teixeira, Maria M. H. Wang, Jennifer C. McGarvey, Valentine Herrmann, Alan J. Tepley, Ben Bond‐Lamberty, David LeBauer   +6 more
openalex   +1 more source

Clinical characteristics in patients with non-alcoholic steatohepatitis in Japan: a case–control study using a 5-year large-scale claims database [PDF]

, 2023
Kei Tokutsu, Kaoru Ito, S. Kawazoe, Sota Minami, Kenji Fujimoto, Keiji Muramatsu, Shinya Matsuda   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development of a database for chemical mechanism assignments for volatile organic emissions [PDF]

, 2015
William Carter
openalex   +1 more source

Comparison of machine learning algorithms to SAPS II in predicting in-hospital mortality of fractures of the pelvis and acetabulum: analyzes based on MIMIC-III database [PDF]

, 2022
Xiang Jiang, Weifan Dai, Yanrong Cai Yanrong Cai   +2 more
openalex   +1 more source