Results 81 to 90 of about 966,411 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Enhancing PV feed-in power forecasting through federated learning with differential privacy using LSTM and GRU

Energy and AI
Given the inherent fluctuation of photovoltaic (PV) generation, accurately forecasting solar power output and grid feed-in is crucial for optimizing grid operations.
Pascal Riedel, Kaouther Belkilani, Manfred Reichert, Gerd Heilscher, Reinhold von Schwerin   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A multi-objective evolutionary algorithm for detecting protein complexes in PPI networks using gene ontology

Scientific Reports
Detecting protein complexes is crucial in computational biology for understanding cellular mechanisms and facilitating drug discovery. Evolutionary algorithms (EAs) have proven effective in uncovering protein complexes within networks of protein–protein ...
Mustafa N. Abbas, David Broneske, Gunter Saake   +2 more
doaj   +1 more source

Let's talk about it: Dialogues with multimedia databases. Database support for human activity [PDF]

, 1997
We describe two scenarios of user tasks in which access to multimedia data plays a significant role. Because current multimedia databases cannot support these tasks, we introduce three new requirements on multimedia databases: multimedia objects should ...
Veer, G.C., Vries, Arjen, van der Veer, Gerrit C., Blanken, Henk, Veer, G.C. van der, Vries, A.P. (Arjen) de, de Vries, Arjen P., de Vries, A.P., Blanken, Henk M., Blanken, H.M.   +9 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

TOMOC: a topology-driven multi-objective evolutionary framework for robust overlapping protein complex detection in noisy PPI networks

BMC Bioinformatics
Background Protein complexes constitute fundamental functional modules within cells and play a crucial role in regulating many biological processes.
Mustafa Abbas, David Broneske, Gunter Saake   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

SEMANTIC SEARCH BASED ON NATURAL LANGUAGE PROCESSING – A NUMISMATIC EXAMPLE

Journal of Ancient History and Archaeology, 2018
Iconographic representations on ancient artifacts are described in many existing databases and literature as human readable text. We applied Natural Language Processing (NLP) approaches in order to extract the semantics out of these textual descriptions ...
Karsten Tolle, Patricia Klinger, Sebastian Gampe, Ulrike Peter   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source