Results 81 to 90 of about 1,729,857 (317)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Issues in student training and use of electronic bibliographic databases [PDF]
, 1999 In an article in this journal Ottewill and Hudson (1997) raised a number of issues concerning students’ use of electronic bibliographic databases. They emphasized the need for co‐operation between academics and librarians in database training and in ...
Miriam Catterall +3 more
core +1 more source
Scientific ReportsDetecting protein complexes is crucial in computational biology for understanding cellular mechanisms and facilitating drug discovery. Evolutionary algorithms (EAs) have proven effective in uncovering protein complexes within networks of protein–protein ...
Mustafa N. Abbas +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Supporting Data mining of large databases by visual feedback queries [PDF]
, 1993 In this paper, we describe a query system that provides visual relevance feedback in querying large databases. Our goal is to support the process of data mining by representing as many data items as possible on the display.
Kriegel, Hans-Peter +2 more
core +1 more source
Frontiers in Aging Neuroscience, 2017 For understanding the heterogeneity of tinnitus, large samples are required. However, investigations on how samples recruited by different methods differ from each other are lacking.
Thomas Probst +12 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A Comparison between Two Main Academic Literature Collections: Web of Science and Scopus Databases [PDF]
, 2014 Nowadays, the world’s scientific community has been publishing an enormous number of papers in different scientific fields. In such environment, it is essential to know which databases are equally efficient and objective for literature searches. It seems
Ale Ebrahim, Nader
core +1 more source
Algebraic and Geometric Characterizations of Double-Cross Matrices of Polylines
ISPRS International Journal of Geo-Information, 2016 We study the double-cross matrix descriptions of polylines in the two-dimensional plane. The double-cross matrix is a qualitative description of polylines in which exact, quantitative information is given up in favour of directional information.
Bart Kuijpers, Bart Moelans
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source