Results 61 to 70 of about 3,306,534 (272)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Smartphone Apps in the Context of Tinnitus: Systematic Review

Sensors, 2020
Smartphones containing sophisticated high-end hardware and offering high computational capabilities at extremely manageable costs have become mainstream and an integral part of users’ lives.
Muntazir Mehdi, Constanze Riha, Patrick Neff, Albi Dode, Rüdiger Pryss, Winfried Schlee, Manfred Reichert, Franz J. Hauck   +7 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A multi-objective evolutionary algorithm for detecting protein complexes in PPI networks using gene ontology

Scientific Reports
Detecting protein complexes is crucial in computational biology for understanding cellular mechanisms and facilitating drug discovery. Evolutionary algorithms (EAs) have proven effective in uncovering protein complexes within networks of protein–protein ...
Mustafa N. Abbas, David Broneske, Gunter Saake   +2 more
doaj   +1 more source

View Selection in Semantic Web Databases [PDF]

, 2011
We consider the setting of a Semantic Web database, containing both explicit data encoded in RDF triples, and implicit data, implied by the RDF semantics. Based on a query workload, we address the problem of selecting a set of views to be materialized in
François Goasdoué, François Goasdoué, Ioana Manolescu, Julien Leblay, Julien Leblay, Konstantinos Karanasos, Konstantinos Karanasos, Équipes-projets Leo   +7 more
core   +10 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Outpatient Tinnitus Clinic, Self-Help Web Platform, or Mobile Application to Recruit Tinnitus Study Samples?

Frontiers in Aging Neuroscience, 2017
For understanding the heterogeneity of tinnitus, large samples are required. However, investigations on how samples recruited by different methods differ from each other are lacking.
Thomas Probst, Thomas Probst, Rüdiger C. Pryss, Berthold Langguth, Myra Spiliopoulou, Michael Landgrebe, Michael Landgrebe, Markku Vesala, Stephen Harrison, Johannes Schobel, Manfred Reichert, Michael Stach, Winfried Schlee   +12 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Algebraic and Geometric Characterizations of Double-Cross Matrices of Polylines

ISPRS International Journal of Geo-Information, 2016
We study the double-cross matrix descriptions of polylines in the two-dimensional plane. The double-cross matrix is a qualitative description of polylines in which exact, quantitative information is given up in favour of directional information.
Bart Kuijpers, Bart Moelans
doaj   +1 more source