Results 131 to 140 of about 243,085 (284)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Persistent Sleepiness After Effective Positive Airway Pressure Therapy Deserves Independent Clinical Evaluation. [PDF]

Cureus
Pham B.
europepmc   +1 more source

Association among Dietary Inflammatory Index, sleep quality and nutritional status in fixed daytime and rotating shift workers. [PDF]

PLoS One
Sünbül Ş, Türker PF.
europepmc   +1 more source

Re‐Emergence of Eurasian Otter (Lutra lutra) in the Valley of Kashmir, India: A Conservation Triumph and a Challenge

Biological Diversity, EarlyView.
Strategies for otter rewilding and conservation in the Kashmir Valley must include protecting and improving otter habitats, Education and awareness to get over harms of myths and strict law enforcement to prevent hunting. ABSTRACT Kashmir Valley is a unique landscape nestled in the northwest Himalaya.
Irfan Khursheed Shah, Sohail Ahmad Wagay
wiley   +1 more source

Digital Inclusion Pathways and Influencing Factors Among Older Adults in Outpatient Settings: A Grounded Theory Study

Clinical Interventions in Aging
Yulu Chen,1,* Qianyu Yin,2,* Tingting Zhou,3 Sijia Gu,4 Liling Xie,5 Mingzhao Xiao,5 Longqiong Wang,5 Qinghua Zhao5 1Daytime Medical Center, Women’s and Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...
Chen Y, Yin Q, Zhou T, Gu S, Xie L, Xiao M, Wang L, Zhao Q   +7 more
doaj  

Above-Threshold Ambulatory Systolic Pressure and Left Ventricular Mass in Chronic Kidney Disease: Does AUC Add Beyond Mean Pressure? [PDF]

J Clin Hypertens (Greenwich)
Zhang Z, Dong X, Ding X, Jiang W, Fang Y.   +4 more
europepmc   +1 more source

Knowledge gaps and research directions in migration ecology for advancing the conservation of migratory songbirds

Biological Reviews, EarlyView.
ABSTRACT Understanding migration ecology is essential for effective conservation of migratory species. To achieve a comprehensive understanding of the ecology of migrating species, it is necessary to study how species react to the complex interplay of intrinsic and extrinsic conditions when optimizing their migratory journey in terms of survival ...
Daniel A. F. Bloche, Heiko Schmaljohann, Nir Sapir   +2 more
wiley   +1 more source

Comprehensive management of chronic insomnia in Spain: a multidisciplinary modified RAND/UCLA consensus with recommendations on daridorexant. [PDF]

Front Psychiatry
Álvarez-Ruiz-Larrinaga A, Armenteros L, Bellido C, Triguero LL, Martínez-Raga J, Pascual J, San L.   +6 more
europepmc   +1 more source