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Narcolepsy Diagnosis With Sleep Stage Features Using PSG Recordings
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023 Narcolepsy is a sleep disorder affecting millions of people worldwide and causes serious public health problems. It is hard for doctors to correctly and objectively diagnose narcolepsy.
Jiquan Wang +7 more
doaj +2 more sources
Communications Medicine, 2022 Järvelä et al. investigate if narcolepsy is associated with altered brain pulsations using ultrafast fMRI. They find differences in the brain pulsations between narcolepsy type 1 patients and healthy controls that may link to altered brain clearance in ...
Matti Järvelä +5 more
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Sleep Medicine, 2021 OBJECTIVE/BACKGROUND The real-world experience of people with narcolepsy is not well understood. PATIENTS/METHODS The Nexus Narcolepsy Registry (NCT02769780) is a longitudinal, web-based patient registry of self-reported data from adults with physician-
Jed Black, Miriam G Cisternas
exaly +2 more sources
Hypocretin (orexin) deficiency in human narcolepsy
Lancet, The, 2000 Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.
Beth Ripley +2 more
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Recent advances in treatment for narcolepsy
Therapeutic Advances in Neurological Disorders, 2019 Narcolepsy type 1 (NT1) is a chronic orphan disorder, caused by the selective and irreversible loss of hypocretin/orexin (ORX) neurons, by a probable autoimmune process.
Lucie Barateau, Yves Dauvilliers
exaly +2 more sources
European guideline and expert statements on the management of narcolepsy in adults and children
European Journal of Neurology, 2021 Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence‐based guidelines for the management of narcolepsy in both adults and children.
C. Bassetti +17 more
semanticscholar +2 more sources
Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]
Encephalitis, 2021 Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
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Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Narcolepsy with cataplexy is characterized by excessive daytime sleepiness and sudden loss of muscle tone (cataplexy) triggered by strong emotions.
A. Seifinejad +20 more
semanticscholar +1 more source
Exploring the Literature on Narcolepsy: Insights into the Sleep Disorder That Strikes during the Day
NeuroSci, 2023 Narcolepsy is a chronic sleep disorder that disrupts the regulation of a person’s sleep–wake cycle, leading to significant challenges in daily functioning.
Ana-Maria Mațotă +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Narcolepsy is a sleep disorder caused by deficient orexin signaling due to orexin neuron degeneration. However, the neural mechanisms underlying the rapid eye movement (REM) sleep-related symptomatology of narcolepsy remain unclear.
Hiroto Ito +7 more
semanticscholar +1 more source