Results 21 to 30 of about 38,442 (298)

Health-related stigma as a determinant of functioning in young adults with narcolepsy. [PDF]

PLoS ONE, 2015
Symptoms of narcolepsy tend to arise during adolescence or young adulthood, a formative time in human development during which people are usually completing their education and launching a career.
Mary C Kapella, Barbara E Berger, Boris A Vern, Sachin Vispute, Bharati Prasad, David W Carley   +5 more
doaj   +1 more source

Increased Numbers of CD4⁺ T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1. [PDF]

Ann Neurol
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Shan L, Fonville M, Hoekstra M, Fronczek R, Smolders J, Swaab DF.   +5 more
europepmc   +2 more sources

Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients.
Renata Carvalho CREMASCHI, Camila HIROTSU, Sergio TUFIK, Fernando Morgadinho COELHO   +3 more
doaj   +1 more source

Nootropics use in the workplace. Psychiatric and ethical aftermath towards the new frontier of bioengineering [PDF]

, 2020
OBJECTIVE: The authors have sought to expound upon and shed a light on the rise of nootropics, which have gradually taken on a more and more relevant role in workplaces and academic settings.
Bersani, G, Ciallella, C, Del Rio, A, Marinelli, E, Rinaldi, Raffaella, Zaami, S   +5 more
core   +1 more source

Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss. [PDF]

, 2017
The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method
McGregor, Ronald, Shan, Ling, Siegel, Jerome M, Wu, Ming-Fung   +3 more
core   +6 more sources

Diagnosis and treatment of narcolepsy and parasomnias

Sichuan jingshen weisheng, 2021
The purpose of this article is to discuss the clinical diagnosis and treatment of narcolepsy and parasomnias. In view of high probability and great harm of missed diagnosis and misdiagnosis of narcolepsy， as well as its close association with parasomnias，
Zhou Junying
doaj   +1 more source

Autoimmunity and Immunotherapy in Narcolepsy [PDF]

Sleep Medicine Research, 2017
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. Narcolepsy is caused by damage of hypocretin producing neurons in the lateral hypothalamus.
Min Jae Seong, Seung Bong Hong
doaj   +1 more source

Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy

Neurobiology of Disease, 2001
Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy.
Beth Ripley, Nobuhiro Fujiki, Mutsumi Okura, Emmanuel Mignot, Seiji Nishino   +4 more
doaj   +1 more source

Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy

Communications Medicine, 2022
Järvelä et al. investigate if narcolepsy is associated with altered brain pulsations using ultrafast fMRI. They find differences in the brain pulsations between narcolepsy type 1 patients and healthy controls that may link to altered brain clearance in ...
Matti Järvelä, Janne Kananen, Vesa Korhonen, Niko Huotari, Hanna Ansakorpi, Vesa Kiviniemi   +5 more
doaj   +1 more source

Sleep Disorders and Genes [PDF]

, 2019
Versão preprintThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle.
Amici, Amin, Ban, Barbagallo, Basheer, Borbely, Brando, Brower, Byrne, Cade, Cade, Carskadon, Chaki, Chang, Chase, Chatterjee, Chen, Cohen, Cohen, Dall’Ara, de Lima, Dement, Dijk, Dong, Evans, Franco-Tormo, Fuh, Gan-Or, Gillombardo, Gottesmann, Gottesmann, Guilleminault, Han, Hennessy, Hirotsu, Hobson, Hobson, Hu, Huang, Huang, Jinek, Johansson, Keenan, Khan, Li, Lin, Lind, Luo, Lusk, Mahowald, Mendlewicz, Mistlberger, Miyagawa, Monti, Murillo-Rodríguez, Naiman, Nir, Nishino, Nordgren, Ollila, Pace-Schott, Palagini, Panda, Pandi-Perumal, Parish, Parmeggiani, Parsons, Patel, Peirano, Petit, Posner, Potter, Rechtschaffen, Riddle, Rizzo, Roffwarg, Scammell, Scherer, Serretti, Serretti, Shalem, Siclari, Siegel, Spada, Subramani, Szentkirályi, Tafti, Torterolo, Torterolo, Torterolo, Torterolo, Torterolo, Toth, Toyoda, Truong, Turek, Utge, van Maanen, Videnovic, Von Economo, Wu, Yong   +101 more
core   +1 more source