Results 21 to 30 of about 33,202 (275)
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Despite the discovery of the orexin (hypocretin) neuropeptides in 1998 and their role in narcolepsy type 1 (NT1), current pharmacotherapy addresses only the associated symptoms and not the underlying loss of orexin. Danavorexton (TAK-925) is
R. Evans +13 more
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Cardiovascular Burden of Narcolepsy Disease (CV-BOND): a real-world evidence study
Sleep, 2022 Study Objectives Narcolepsy is associated with cardiovascular risk factors; however, the risk of new-onset cardiovascular events in this population is unknown.
R. Ben-Joseph +6 more
semanticscholar +1 more source
Etiopathogenesis and Neurobiology of Narcolepsy: A Review [PDF]
Journal of Clinical and Diagnostic Research, 2014 Narcolepsy is a chronic lifelong sleep disorder and it often leaves a debilitating effect on the quality of life of the sufferer. This disorder is characterized by a tetrad of excessive daytime sleepiness, cataplexy (brief loss of muscle tone following ...
Swarup Kumar, Haritha Sagili
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Progress on narcolepsy and anxiety
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness (EDS), cataplexy, sleep hallucination and sleep paralysis, and the vast majority of patients are accompanied by anxiety. There are neuronal interconnections and projections
YU Jie⁃yang +5 more
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Disrupted nighttime sleep and sleep instability in narcolepsy
Journal of Clinical Sleep Medicine (JCSM), 2021 This review aimed to summarize current knowledge about disrupted nighttime sleep (DNS) and sleep instability in narcolepsy, including self-reported and objective assessments, potential causes of sleep instability, health consequences and functional ...
K. Maski +3 more
semanticscholar +1 more source
Health-related stigma as a determinant of functioning in young adults with narcolepsy. [PDF]
PLoS ONE, 2015 Symptoms of narcolepsy tend to arise during adolescence or young adulthood, a formative time in human development during which people are usually completing their education and launching a career.
Mary C Kapella +5 more
doaj +1 more source
Autoimmunity and Immunotherapy in Narcolepsy [PDF]
Sleep Medicine Research, 2017 Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. Narcolepsy is caused by damage of hypocretin producing neurons in the lateral hypothalamus.
Min Jae Seong, Seung Bong Hong
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Cardiovascular disorders in narcolepsy: Review of associations and determinants.
Sleep Medicine Reviews, 2021 Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined by clinical symptoms, neurophysiological findings, and low hypocretin levels.
P. Jennum +4 more
semanticscholar +1 more source
Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients.
Renata Carvalho CREMASCHI +3 more
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Nature Reviews Disease Primers, 2017 Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is characterized by excessive daytime sleepiness, which can have severe consequences for the patient. Problems faced by patients with narcolepsy include social stigma associated with this disease, difficulties in obtaining an education and keeping a job, a reduced ...
Kornum, Birgitte R. +6 more
openaire +5 more sources