Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review. [PDF]
Brain BehavThis visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Hastings NE +12 more
europepmc +2 more sources
Once-Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy. [PDF]
J Sleep ResABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Ortiz LE +7 more
europepmc +2 more sources
Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years. [PDF]
J Sleep ResABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhang Z +4 more
europepmc +2 more sources
Facial Emotion Recognition in Children With Narcolepsy Type 1. [PDF]
J Sleep ResABSTRACT Narcolepsy type 1 is a neurological disorder typically emerging in childhood or adolescence, characterised by excessive daytime sleepiness, cataplexy and rapid eye movement sleep‐related symptoms. Beyond its core features, increasing evidence suggests an impact on socio‐cognitive development, including difficulties in understanding others ...
Veneruso M +11 more
europepmc +2 more sources
Case Report: Narcolepsy patients masked behind obstructive sleep apnea syndrome (OSAS): report of 2 cases and literature review [PDF]
Frontiers in NeuroscienceObstructive sleep apnea syndrome (OSAS) and narcolepsy are sleep disorders that commonly present with excessive daytime sleepiness (EDS). OSAS is characterized by recurrent upper airway obstruction during sleep, leading to intermittent hypoxia and sleep ...
Simin Zou +5 more
doaj +2 more sources
Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy
iScience, 2023 Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion.
Brandon A. Toth +3 more
doaj +1 more source
BMC Neuroscience, 2022 Background Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients.
Mayuko Yoshida +2 more
doaj +1 more source
Activity of putative orexin neurons during cataplexy
Molecular Brain, 2022 It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou +7 more
doaj +1 more source
Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]
PLoS ONE, 2010 BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau +8 more
doaj +1 more source
Clinical and Polysomnographic Comparison between Narcolepsy without Cataplexy and Idiopathic Hypersomnia [PDF]
Sleep Medicine Research, 2012 Background and Objective The aim of this study is to compare the clinical, electrophysiological (Polysomnography, PSG; Multiple Sleep Latency Test, MSLT) and biological data (HLA DQB1*0602 typing) in idiopathic hypersomnia with narcolepsy without ...
Tae Won Kim +7 more
doaj +1 more source