Results 1 to 10 of about 4,469 (181)

Cataplexy response with extended-release once-nightly sodium oxybate: Post hoc responder analyses from the phase 3 REST-ON clinical trial

Sleep Medicine: X
Background: Once-nightly sodium oxybate (ON-SXB), an extended-release oxybate formulation, yielded significant (P 
Michael J. Thorpy, Clete A. Kushida, Richard Bogan, Akinyemi O. Ajayi, Bruce C. Corser, Jennifer Gudeman   +5 more
doaj   +1 more source

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Nature Communications, 2020
Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti   +4 more
doaj   +1 more source

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source

Treatment paradigms for cataplexy in narcolepsy: past, present, and future

Nature and Science of Sleep, 2015
Todd J Swick1–4 1Department of Neurology, University of Texas School of Medicine-Houston, Houston; 2The Sleep Center at North Cypress Medical Center, Cypress; 3Apnix Sleep Diagnostics, Houston; 4Neurology and Sleep Medicine Consultants, Houston, TX,
Swick TJ
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TNF and IL-6 levels in narcoleptic patients [PDF]

Einstein (São Paulo), 2006
Objective: To evaluate the presence of HLA-DQB1*0602 allele, tumornecrosis factor and interleukin-6 in patients with cataplexy andcontrols. Methods: A prospective controlled study with 22 patientsdiagnosed as narcoleptic according to DSM4 criteria and 17
Fernando Morgadinho Santos Coelho, Heraldo Possolo de Sousa, Gabriela Rodrigues Alves, Lia Rita Azeredo Bittencourt, Márcia Pradella-Hallinan, Fábio Moreira, Mário Pedrazzoli Neto, Sérgio Tufik   +7 more
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Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life

Journal of Sleep Research, EarlyView.
Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life. ABSTRACT In the central disorders of hypersomnolence (CDH) narcolepsy types 1 and 2 (NT1, NT2) and idiopathic hypersomnia (IH), mental health problems are highly prevalent, and quality of life is decreased.
Denise Bijlenga, Tessa F. Blanken, Josephine J. de Boer, Rolf Fronczek, Gert Jan Lammers   +4 more
wiley   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Ambulatory video-EEG-EMG monitoring and analysis during cataplexy in narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Objective To comprehensively analyze the clinical and electroneurophysiological characteristics during the process of cataplexy by dynamic video?EEG?EMG monitoring.
Bei HUANG, Kun CHEN, Zong-wen WANG, Zhong-xin ZHAO, Hui-juan WU   +4 more
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