Results 1 to 10 of about 4,632 (177)

The G protein-coupled estrogen receptor in the nucleus accumbens mediates the estrogen-induced increase in cataplexy-like behavior [PDF]

Scientific Reports
Estrogen functions not only as a female reproductive hormone but also as a psychological agent in the brains of both sexes. Here, we examined the potential effect of estrogen on cataplexy attacks, which are triggered by positive emotions in narcoleptic ...
Jun Kaminosono, Hikari Nagayama, Ikue Kusumoto-Yoshida, Hideki Kashiwadani, Tomoyuki Kuwaki   +4 more
doaj   +2 more sources

Human narcolepsy is linked to degeneration of both locus coeruleus and hypocretin neurons [PDF]

Nature Communications
Earlier studies led to the conclusion that human narcolepsy with cataplexy was correlated with the loss of hypocretin (Hcrt = orexin) neurons in the hypothalamus.
Thomas C. Thannickal, Ming-Fung Wu, Marcia E. Cornford, Jerome M. Siegel   +3 more
doaj   +2 more sources

Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy

iScience, 2023
Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion.
Brandon A. Toth, Katie S. Chang, Sarah Fechtali, Christian R. Burgess   +3 more
doaj   +1 more source

Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test

BMC Neuroscience, 2022
Background Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients.
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki   +2 more
doaj   +1 more source

Activity of putative orexin neurons during cataplexy

Molecular Brain, 2022
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki   +7 more
doaj   +1 more source

Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau, Sophie Bayard, Quentin Coquerel, Pierre Déchelotte, Christine Bole-Feysot, Bertrand Carlander, Valérie Cochen De Cock, Sergueï O Fetissov, Yves Dauvilliers   +8 more
doaj   +1 more source

Clinical and Polysomnographic Comparison between Narcolepsy without Cataplexy and Idiopathic Hypersomnia [PDF]

Sleep Medicine Research, 2012
Background and Objective The aim of this study is to compare the clinical, electrophysiological (Polysomnography, PSG; Multiple Sleep Latency Test, MSLT) and biological data (HLA DQB1*0602 typing) in idiopathic hypersomnia with narcolepsy without ...
Tae Won Kim, Se Yeon Chang, Soo Hyun Joo, Ho Jun Seo, Jong Hyun Jeong, Jin Hee Han, Emmanuel Mignot, Seung Chul Hong   +7 more
doaj   +1 more source

Activation of the rostral nucleus accumbens shell by optogenetics induces cataplexy-like behavior in orexin neuron-ablated mice

Scientific Reports, 2023
Cataplexy is one of the symptoms of type 1 narcolepsy, characterized by a sudden loss of muscle tone. It can be seen as a behavioral index of salience, predominantly positive emotion, since it is triggered by laughter in humans and palatable foods in ...
Shigetaka Kawashima, Fan Lou, Ikue Kusumoto-Yoshida, Liying Hao, Tomoyuki Kuwaki   +4 more
doaj   +1 more source

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

eLife, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy.
Ying Sun, Carlos Blanco-Centurion, Emmaline Bendell, Aurelio Vidal-Ortiz, Siwei Luo, Meng Liu   +5 more
doaj   +1 more source

Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice

Communications Biology, 2021
Kuwaki and Kanno examine courtship behavior in orexin neuron-ablated mice (ORX-AB), which are a model of narcolepsy/cataplexy. They find that ORX-AB mice showed cataplexy-like behavior during both dark and light periods in response to a female encounter,
Tomoyuki Kuwaki, Kouta Kanno
doaj   +1 more source