Results 41 to 50 of about 8,772 (223)

The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy

Frontiers in Neuroscience, 2021
Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, episodes of paralysis during wakefulness.
Alissa A. Coffey, Adam A. Joyal, Akihiro Yamanaka, Thomas E. Scammell   +3 more
doaj   +1 more source

Dental Implant for a Patient with Narcolepsy: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2020
Narcolepsy is a neurological disorder characterised by cataplexy, sleep paralysis and excessive daytime sleepiness. The literature on dental managements of patients with narcolepsy is lacking with no set guidelines for dental practitioners.
Hani Mawardi, Yasser Mahfouz, Siraj Dakhil, Mohammed Zahran, Lena Elbadawi   +4 more
doaj   +1 more source

An Australian standard of care for Niemann–Pick disease type C

Internal Medicine Journal, EarlyView.
Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan, Nicholas Smith, Heidi Peters, Ellie Van Velsen, Catherine Marraffa, Carolyn Ellaway, Katrina Cruz, Shekeeb S. Mohammad, Maina Kava, Joy Yaplito‐Lee, Shanti Balasubramaniam, Yusof Rahman, Brendon Boot, Ashley Bush, Felicity Munro, Leniza Hamoy, Ya Hui Hung, Philippa Johnston, Deanna Carpino, Molly Williams, Sharmila Kiss, Rebecca Quin, Ingrid Sutherland, Mark Walterfang   +23 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source

Narcolepsy Patient Presenting as Drop Attack without Emotional Triggering and Subjective Sleepiness [PDF]

Sleep Medicine Research, 2016
Narcolepsy type I is characterized by excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hypnagogic hallucination, and fragmented night-time sleep.
Joon Hyun Baek, Ji-Ye Jeon, Sang-Ahm Lee
doaj   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Narcolepsy Following Yellow Fever Vaccination: A Case Report [PDF]

, 2016
Narcolepsy with cataplexy is a rare, but important differential diagnosis for daytime sleepiness and atonic paroxysms in an adolescent. A recent increase in incidence in the pediatric age group probably linked to the use of the Pandemrix influenza ...
Deb K. Pal, Michael Farquhar, Paul Gringras, Richard E. Rosch   +3 more
core   +3 more sources

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Nature Communications, 2020
Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti   +4 more
doaj   +1 more source

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

Narcolepsy [PDF]

, 2007
BACKGROUND: Narcolepsy is a chronic neurological syndrome with prevalence between 0.018% and 0.040% without important ethnic differences. Narcolepsy is characterized by excessive daytime sleepiness and cataplexy. The pathophysiology of the illness is not
Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Elias, Rosilene Motta, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +3 more sources