Results 41 to 50 of about 5,885 (217)

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source

Cataplexy response with extended-release once-nightly sodium oxybate: Post hoc responder analyses from the phase 3 REST-ON clinical trial

Sleep Medicine: X
Background: Once-nightly sodium oxybate (ON-SXB), an extended-release oxybate formulation, yielded significant (P 
Michael J. Thorpy, Clete A. Kushida, Richard Bogan, Akinyemi O. Ajayi, Bruce C. Corser, Jennifer Gudeman   +5 more
doaj   +1 more source

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Weak with sex: sexual intercourse as a trigger for cataplexy [PDF]

, 2009
Introduction. Sudden, often positive emotions are typical triggers for cataplexy in patients with narcolepsy-cataplexy (NC). Cataplexy during sexual intercourse and orgasm (orgasmolepsy) has been previously reported, but its frequency and characteristics
Poryazova, R, Bassetti, C L, Khatami, R, Werth, E; https://orcid.org/   +3 more
core   +1 more source

TNF and IL-6 levels in narcoleptic patients [PDF]

Einstein (São Paulo), 2006
Objective: To evaluate the presence of HLA-DQB1*0602 allele, tumornecrosis factor and interleukin-6 in patients with cataplexy andcontrols. Methods: A prospective controlled study with 22 patientsdiagnosed as narcoleptic according to DSM4 criteria and 17
Fernando Morgadinho Santos Coelho, Heraldo Possolo de Sousa, Gabriela Rodrigues Alves, Lia Rita Azeredo Bittencourt, Márcia Pradella-Hallinan, Fábio Moreira, Mário Pedrazzoli Neto, Sérgio Tufik   +7 more
doaj  

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, EarlyView.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

Sodium Oxybate Alters Sleep Architecture and Reduces Emotional Selectivity in Memory‐Related Responses

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep supports memory consolidation. Non‐rapid eye movement (NREM) and rapid eye movement (REM) sleep have been proposed to support, respectively, declarative memory consolidation and the integration of the memory affective dimension. Here, we used sodium oxybate (SXB) to modify the NREM/REM proportion during one sleep night and assessed ...
Laure Colin, Kinga Igloi, Alison Montagrin, Samika Kumar, Jeremy Hofmeister, Markus Gschwind, Sophie Schwartz, Virginie Sterpenich   +7 more
wiley   +1 more source

Ambulatory video-EEG-EMG monitoring and analysis during cataplexy in narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Objective To comprehensively analyze the clinical and electroneurophysiological characteristics during the process of cataplexy by dynamic video?EEG?EMG monitoring.
Bei HUANG, Kun CHEN, Zong-wen WANG, Zhong-xin ZHAO, Hui-juan WU   +4 more
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