Results 51 to 60 of about 5,885 (217)

Polysomnographic Assessment of Sleep Comorbidities in Drug-Naïve Narcolepsy-Spectrum Disorders--A Japanese Cross-Sectional Study. [PDF]

PLoS ONE, 2015
This is a large cross-sectional study which aimed to investigate comorbidity rate, degree of sleep-related breathing disorder, polysomnigraphically diagnosible rapid eye movement sleep behavior disorder/rapid eye movement sleep without atonia and ...
Taeko Sasai-Sakuma, Akihiko Kinoshita, Yuichi Inoue   +2 more
doaj   +1 more source

Risk of Insomnia Disorder in Japanese Cancer Patients: A Matched Cohort Study Using Employer‐Based Health Insurance Claims Data

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Insomnia is a common clinical symptom that significantly impairs quality of life (QOL) and it frequently occurs in cancer patients. However, the risk of insomnia in Japanese cancer patients compared with cancer‐free patients has not yet been studied.
Risa Murakami, Hiroyuki Sato, Akihiro Hirakawa   +2 more
wiley   +1 more source

Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review

Cogent Medicine, 2017
The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci, Warwick Hosking, Dorothy Bruck   +2 more
doaj   +1 more source

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

A case of an 11-year-old girl diagnosed with OCD developing giggle incontinence following addition of aripiprazole to treatment

Psychiatry and Clinical Psychopharmacology, 2018
Giggle incontinence (GI) is characterized by involuntary and generally unpredictable release of urine during giggling or laughter. It has been suggested that GI may be a centrally mediated disorder and may share a common pathophysiology with narcolepsy ...
İsmail Akaltun, Tayfun Kara, Hamza Ayaydın   +2 more
doaj   +1 more source

Cerebral perfusion changes during cataplexy in narcolepsy patients

, 2020
To localize cerebral perfusion differences during cataplexy, brain SPECT subtraction was performed between cataplexy and baseline awake period or REM sleep in patients with narcolepsy.
주은연
core   +1 more source

An Australian standard of care for Niemann–Pick disease type C

Internal Medicine Journal, Volume 56, Issue 5, Page 832-848, May 2026.
Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan, Nicholas Smith, Heidi Peters, Ellie Van Velsen, Catherine Marraffa, Carolyn Ellaway, Katrina Cruz, Shekeeb S. Mohammad, Maina Kava, Joy Yaplito‐Lee, Shanti Balasubramaniam, Yusof Rahman, Brendon Boot, Ashley Bush, Felicity Munro, Leniza Hamoy, Ya Hui Hung, Philippa Johnston, Deanna Carpino, Molly Williams, Sharmila Kiss, Rebecca Quin, Ingrid Sutherland, Mark Walterfang   +23 more
wiley   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 736-746, April 2026.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]

, 2007
[spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
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