Results 51 to 60 of about 8,772 (223)

Automatic detection of cataplexy [PDF]

Sleep Medicine, 2018
Although being the most specific symptom of narcolepsy type 1 (NT1), cataplexy is currently investigated by clinical interview only, with potential diagnostic pitfalls. Our study aimed at testing the accuracy of an automatic video detection of cataplexy in NT1 patients vs.
Bartolini, Ilaria, Pizza, Fabio, Di Luzio, Andrea, Neccia, Giulia, Antelmi, Elena, Vandi, Stefano, Plazzi, Giuseppe   +6 more
openaire   +2 more sources

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source

Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children [PDF]

, 2017
Astute control of brain activity states is critical for adaptive behaviours and survival. In mammals and birds, electroencephalographic recordings reveal alternating states of wakefulness, slow wave sleep and paradoxical sleep (or rapid eye movement ...
Dellepiane, Jose M., Emmenegger, Yann, Franken, Paul, Jimenez, Sonia, Plazzi, Giuseppe, Tafti, Mehdi, Vandi, Stefano, Vassalli, Anne   +7 more
core  

Relato de dois casos de pacientes com narcolepsia com melhora dos sintomas após uso de prednisona [PDF]

, 2007
This article focuses on 2 clinical case reports of narcoleptic patients who experienced an absence of excessive sleepiness during treatment of other illnesses with 40 mg daily intake of prednisone.Este artigo refere-se à discussão de 2 casos de pacientes
Alves, Gabriela Rodrigues, Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +2 more sources

Baclofen for narcolepsy with cataplexy: two cases

Nature and Science of Sleep, 2015
Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep ...
Lee EK, Douglass AB
doaj  

Cataplexy response with extended-release once-nightly sodium oxybate: Post hoc responder analyses from the phase 3 REST-ON clinical trial

Sleep Medicine: X
Background: Once-nightly sodium oxybate (ON-SXB), an extended-release oxybate formulation, yielded significant (P 
Michael J. Thorpy, Clete A. Kushida, Richard Bogan, Akinyemi O. Ajayi, Bruce C. Corser, Jennifer Gudeman   +5 more
doaj   +1 more source

TNF and IL-6 levels in narcoleptic patients [PDF]

Einstein (São Paulo), 2006
Objective: To evaluate the presence of HLA-DQB1*0602 allele, tumornecrosis factor and interleukin-6 in patients with cataplexy andcontrols. Methods: A prospective controlled study with 22 patientsdiagnosed as narcoleptic according to DSM4 criteria and 17
Fernando Morgadinho Santos Coelho, Heraldo Possolo de Sousa, Gabriela Rodrigues Alves, Lia Rita Azeredo Bittencourt, Márcia Pradella-Hallinan, Fábio Moreira, Mário Pedrazzoli Neto, Sérgio Tufik   +7 more
doaj  

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Polysomnographic Assessment of Sleep Comorbidities in Drug-Naïve Narcolepsy-Spectrum Disorders--A Japanese Cross-Sectional Study. [PDF]

PLoS ONE, 2015
This is a large cross-sectional study which aimed to investigate comorbidity rate, degree of sleep-related breathing disorder, polysomnigraphically diagnosible rapid eye movement sleep behavior disorder/rapid eye movement sleep without atonia and ...
Taeko Sasai-Sakuma, Akihiko Kinoshita, Yuichi Inoue   +2 more
doaj   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source