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Etiopathogenesis and Neurobiology of Narcolepsy: A Review [PDF]

Journal of Clinical and Diagnostic Research, 2014
Narcolepsy is a chronic lifelong sleep disorder and it often leaves a debilitating effect on the quality of life of the sufferer. This disorder is characterized by a tetrad of excessive daytime sleepiness, cataplexy (brief loss of muscle tone following ...
Swarup Kumar, Haritha Sagili
doaj   +1 more source

Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat

Orphanet Journal of Rare Diseases, 2020
Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi, T. Kawazoe, Y. Hamada, T. Kumagai, K. Tsutsui, N. Sakai, K. Eto, A. Noguchi, T. Shimizu, T. Takahashi, G. Han, K. Mishima, T. Kanbayashi, H. Kondo   +13 more
doaj   +1 more source

Feeding-elicited cataplexy in orexin knockout mice [PDF]

, 2009
Mice lacking orexin/hypocretin signaling have sudden episodes of atonia and paralysis during active wakefulness. These events strongly resemble cataplexy, episodes of sudden muscle weakness triggered by strong positive emotions in people with narcolepsy,
Cano, G, Scammell, T E, Clark, E L, Baumann, C R, Mochizuki, T   +4 more
core   +1 more source

Isolated Cataplexy in the Differential Diagnosis of Drop Attacks: A Case of Successful Clinical Diagnosis and Treatment

Case Reports in Neurological Medicine, 2012
Drop attacks are sudden spontaneous falls that are not accompanied by alteration of consciousness and are followed by immediate recovery. Cataplexy, which is usually associated with narcolepsy, is one of the causes of drop attacks.
Robert T. Egel, Anthony Lee, Thomas Bump, Alexander Javois   +3 more
doaj   +1 more source

Narcolepsy with resolution of cataplexy and persisting orexin deficiency.

, 2020
None Narcolepsy type 1 is a debilitating chronic neurological disorder, whose main symptoms of excessive daytime sleepiness and cataplexy may partially improve with time, but typically do not fully resolve.
Wasserman, Danielle, Rosenzweig, Ivana, Bassetti, Claudio L. A.   +2 more
core   +1 more source

The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans

Neurobiology of Disease, 2004
Cataplexy, an emotion-triggered sudden loss of muscle tone specific to narcolepsy, is tightly associated with hypocretin deficiency. Using hypocretin receptor 2 gene (hcrtr 2)-mutated narcoleptic Dobermans, we have previously demonstrated that altered ...
Mutsumi Okura, Nobuhiro Fujiki, Ichiro Kita, Kazuki Honda, Yasushi Yoshida, Emmanuel Mignot, Seiji Nishino   +6 more
doaj   +1 more source

The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy

Frontiers in Neuroscience, 2021
Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, episodes of paralysis during wakefulness.
Alissa A. Coffey, Adam A. Joyal, Akihiro Yamanaka, Thomas E. Scammell   +3 more
doaj   +1 more source

Narcolepsy Patient Presenting as Drop Attack without Emotional Triggering and Subjective Sleepiness [PDF]

Sleep Medicine Research, 2016
Narcolepsy type I is characterized by excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hypnagogic hallucination, and fragmented night-time sleep.
Joon Hyun Baek, Ji-Ye Jeon, Sang-Ahm Lee
doaj   +1 more source

Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). [PDF]

PLoS ONE, 2009
BackgroundSNP rs5770917 located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype were previously identified as susceptibility loci for narcolepsy with cataplexy.
Taku Miyagawa, Makoto Honda, Minae Kawashima, Mihoko Shimada, Susumu Tanaka, Yutaka Honda, Katsushi Tokunaga   +6 more
doaj   +1 more source

Therapy for Cataplexy

, 2020
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose of the review</jats:title> <jats:p>Cataplexy, an involuntary loss of muscle activity triggered by strong emotions is the ...
Dirks, Christina, Heidbreder, Anna, Ramm, Markus   +2 more
core   +1 more source