Results 1 to 10 of about 6,179 (233)
Orexins in apoptosis: a dual regulatory role [PDF]
Frontiers in Cellular NeuroscienceThe orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central ...
Mustafa ahmed Abdel-Reheim +2 more
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The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship [PDF]
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
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Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target
Molecules, 2021 Over 20 years ago, orexin neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) produced from the same precursor in hypothalamus were identified.
Alain Couvineau
exaly +3 more sources
Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases
Frontiers in Endocrinology, 2019 Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy
Alain Couvineau +2 more
exaly +3 more sources
Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Frontiers in Endocrinology, 2019 Originally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy ...
Edward Milbank, Miguel Lopez
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The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress. [PDF]
BiomedicinesThe orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful
Jászberényi M +4 more
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The Orexin receptors: Structural and anti-tumoral properties
Frontiers in Endocrinology, 2022 At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered.
Alain Couvineau +3 more
doaj +1 more source
Orexins and bipolar disorder: A review
European Psychiatry, 2022 Introduction Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have
C. Moya Lacasa +8 more
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Frontiers in Veterinary Science, 2022 Orexins A (OXA) and B (OXB) and the receptors 1 (OX1R) and 2 (OX2R) for orexins are hypothalamic peptides found in several mammalian organs and participated to the control of a wide assortment of physiological and pathological functions. The distribution
Caterina Squillacioti +8 more
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Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
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