Results 1 to 10 of about 176 (49)
The Orexin receptors: Structural and anti-tumoral properties
Frontiers in Endocrinology, 2022 At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered.
Alain Couvineau +3 more
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Orexins and bipolar disorder: A review
European Psychiatry, 2022 Introduction Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have
C. Moya Lacasa +8 more
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Frontiers in Veterinary Science, 2022 Orexins A (OXA) and B (OXB) and the receptors 1 (OX1R) and 2 (OX2R) for orexins are hypothalamic peptides found in several mammalian organs and participated to the control of a wide assortment of physiological and pathological functions. The distribution
Caterina Squillacioti +8 more
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Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target
Molecules, 2021 Over 20 years ago, orexin neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) produced from the same precursor in hypothalamus were identified.
Couvineau Alain +3 more
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Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
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Asian Pacific Journal of Reproduction, 2019 Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong
Pallav Sengupta +3 more
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Life, 2023 Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells.
Iman Mohammadi +5 more
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Orexins in the clinical course of bipolar disorder
European Psychiatry, 2021 Introduction Orexins are involved in the regulation of circadian rhythms which play an important role in mood regulation(1,2), and are hypothesised to be associated with major depressive disorder(3).
C. Moya-Lacasa +4 more
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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases
Frontiers in Endocrinology, 2019 Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy
Alain Couvineau +5 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and ...
Yu⁃chen QIAO +5 more
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