Results 21 to 30 of about 176 (49)
Pharmaceuticals, 2019 Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and B, inhibit nociceptive transmission in the rat spinal dorsal horn.
Eiichi Kumamoto
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Hypothalamic orexinergic neuron changes during the hibernation of the Syrian hamster
Frontiers in Neuroanatomy, 2022 Hibernation in small mammals is a highly regulated process with periods of torpor involving drops in body temperature and metabolic rate, as well as a general decrease in neural activity, all of which proceed alongside complex brain adaptive changes that
Jesús M. López +6 more
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Orexins in apoptosis: a dual regulatory role
Frontiers in Cellular NeuroscienceThe orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central ...
Simona Cavalu +8 more
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Research progress on the mechanism of orexin in pain regulation in different brain regions
Open Life Sciences, 2021 Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui +4 more
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Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders
Frontiers in Behavioral Neuroscience, 2023 Orexin-A and orexin-B, neuropeptides produced exclusively in the lateral hypothalamus, have been implicated in various functions, including memory. Their levels are elevated in certain pathological states, such as PTSD, and lowered in other states, e.g.,
Filip Mazur, Jarosław Całka
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Veterinary SciencesOrexins A (OXA) and B (OXB) and their specific receptors, receptor 1 (OX1R) and 2 (OX2R) for orexins, are hypothalamic peptides involved in orchestrating several functions in the central nervous system and peripheral organs, including sleep, excitement ...
Anna Costagliola +6 more
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Plasma Orexin-A Levels Do Not Undergo Circadian Rhythm in Young Healthy Male Subjects
Frontiers in Endocrinology, 2018 Orexin-A (OXA) has been originally isolated from a precursor peptide prepro-orexin from the lateral hypothalamus. The orexin system has been attributed to important functions in sleep, arousal and regulation of energy homeostasis. In addition to its high
Kari A. Mäkelä +8 more
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Orexinergic System in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2021 Orexinergic system consisting of orexins and orexin receptors plays an essential role in regulating sleep–wake states, whereas sleep disruption is a common symptom of a number of neurodegenerative diseases.
Qinqin Wang +4 more
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Frontiers in Endocrinology, 2019 In states of intestinal dysbiosis, a perturbation of the normal microbiome composition, the intestinal epithelial barrier (IEB) permeability is increased as a result of the disruption of the epithelial tight junction protein network, in which occludin is
Lea Tunisi +14 more
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Orexin System: The Key for a Healthy Life
Frontiers in Physiology, 2017 The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive a variety of signals related to environmental, physiological and emotional
Sergio Chieffi +22 more
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