Frontiers in Oncology, 2022 Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-associated death in the West. This type of cancer has a very poor prognosis notably due to the development of chemoresistance when treatments including gemcitabine and Abraxane
Thierry Voisin +9 more
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Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
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Integrative Physiology of Orexins and Orexin Receptors
CNS & Neurological Disorders - Drug Targets, 2009 Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and ...
Jing⁃huan GAN +4 more
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Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
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Orexin, orexin receptor antagonists and central cardiovascular control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity. This is consistent with the location of orexin neurons in the hypothalamus and the distribution of orexin terminals in the central autonomic network ...
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Overlapping distribution of orexin and endocannabinoid receptors and their functional interaction in the brain of adult zebrafish [PDF]
, 2018 Hypocretins/Orexins neuropeptides are known to regulate numerous physiological functions, such as energy homeostasis, food intake, sleep/wake cycle, arousal and wakefulness, in vertebrates.
Ettore Varricchio +11 more
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A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac [PDF]
, 2013 The aim of this study is the evaluation of electron dose enhancement and photon contamination production by various nanoparticles in the electron mode of a medical linac. MCNPX Monte Carlo code was used for simulation of Siemens Primus linac as well as a
Toossi, Mohammad Taghi Bahreyni +4 more
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Expression of orexin B and its receptor 2 in rat testis [PDF]
, 2017 The peptides orexin A (OxA) and orexin B (OxB) deriving from a common precursor molecule, prepro-orexin, by proteolytic cleavage, bind the two G-coupled OX1 and OX2 receptors.
ASSISI, LOREDANA +7 more
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Children with Narcolepsy type 1 have increased T‐cell responses to orexins
Annals of Clinical and Translational Neurology, 2019 Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4+ and CD8+ T‐cells in response to
Andrew C. Cogswell +5 more
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