Results 1 to 10 of about 18,205 (239)
Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
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Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
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Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]
Journal of Endocrinology, 2006 Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are ...
J E, Digby +5 more
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Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice [PDF]
eLife, 2019 Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal.
Srikanta Chowdhury +10 more
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Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya +2 more
exaly +3 more sources
Orexin, cardio-respiratory function and hypertension
Frontiers in Neuroscience, 2014 In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
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Orexin neurons receive glycinergic innervations. [PDF]
PLoS ONE, 2011 Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood.
Mari Hondo +4 more
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Regenerative TherapyIntroduction: Sensorineural olfactory dysfunction significantly impairs the life quality of patients but without effective treatments to date. Orexin is a neurotrophic factor activates neuronal network activity.
Yin-Tzu Chen +5 more
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Presence of orexin A and orexin 1 receptor in the buffalo prostate
Italian Journal of Animal Science, 2010 The orexins A and B are two peptides discovered initially in the rat lateral hypothalamus involved in the regulation of some body functions such as food intake, sleep/wake cycle, arterial pressure and heart rate. They interact with two receptors defined &
A. Vittoria, F. Russo, G. Petrosino
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Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1. [PDF]
CNS Neurosci TherOrexin B/OX2R signaling attenuates cerebral aneurysm formation by suppressing SP‐1‐mediated inflammation, macrophage infiltration, and endothelial adhesion, with OX2R knockdown abolishing these protective effects. The study highlights Orexin B as a therapeutic candidate targeting vascular inflammation and remodeling in aneurysms.
Chen L, Xu J, Ye F, Luo J, Yu H.
europepmc +2 more sources