Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
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The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications [PDF]
Frontiers in PharmacologyThe orexin (hypocretin) system, composed of the neuropeptides orexin A and orexin B and their receptors OX1R and OX2R, is primarily known for its role in sleep–wake regulation and energy homeostasis.
Daniel Stránský +4 more
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Beyond traditional sleeping pills: safety, efficacy and multidisease potential of three approved orexin receptor antagonists [PDF]
Frontiers in PsychiatryThis is a narrative review aiming to summarize the latest research progress of orexin receptor antagonists in insomnia treatment. To review the latest research progress on orexin receptor antagonists in the treatment of sleep disorders and explore their ...
Zening Yang, Chenshuo Jia, Zhizhao Ma
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Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis. [PDF]
Adv Sci (Weinh)In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Kang X +11 more
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Orexin receptor antagonists attenuate acute stress-induced disruptions in sleep states [PDF]
Frontiers in NeurosciencePost-traumatic stress disorder (PTSD) is characterized by symptoms including hypervigilance, intrusive memories, and sleep disturbance. Insomnia and nightmares are among the most common and clinically important sleep-related symptoms in PTSD, yet ...
Kayla Lilly +5 more
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Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Brain Sciences, 2022 Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
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Activity of putative orexin neurons during cataplexy
Molecular Brain, 2022 It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou +7 more
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Frontiers in Neuroendocrinology, 2018 The neuropeptides orexins are important in regulating the neurobiological systems that respond to stressful stimuli. Furthermore, orexins are known to play a role many of the phenotypes associated with stress-related mental illness such as changes in cognition, sleep-wake states, and appetite.
Laura A, Grafe, Seema, Bhatnagar
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Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
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Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension
Scientific Reports, 2021 Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension.
Rohan Umesh Parekh +6 more
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