Results 31 to 40 of about 20,070 (218)
European Journal of Histochemistry, 2009 The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques.
C Dall’Aglio +6 more
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Roles of orexin in modulating arousal, feeding and motivation
Frontiers in Behavioral Neuroscience, 2013 Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Natsuko eTsujino, Takeshi eSakurai
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Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study
BMC Research Notes, 2022 Objective Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection.
Yasuhiro Ogawa +5 more
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Orphanet Journal of Rare Diseases, 2020 Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi +13 more
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Interactions between Lateral Hypothalamic Orexin and Dorsal Raphe Circuitry in Energy Balance
Brain SciencesOrexin/hypocretin terminals innervate the dorsal raphe nucleus (DRN), which projects to motor control areas important for spontaneous physical activity (SPA) and energy expenditure (EE).
Vijayakumar Mavanji +3 more
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Design and synthesis of orexin 1 receptor-selective agonists [PDF]
, 2022 Orexins are a family of neuropeptides that regulate various physiological events such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., the orexin 1 (OX1R) and orexin 2 receptors (OX2R).
Yasuyuki, Nagumo +11 more
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Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal
Frontiers in Neuroscience, 2021 The lateral hypothalamus (LH) is classically implicated in sleep-wake control. It is the main source of orexin/hypocretin and melanin-concentrating hormone (MCH) neuropeptides in the brain, which have been both implicated in arousal state switching ...
Cristina Concetti, Denis Burdakov
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The Regulation of Sleep and Wakefulness by the Hypothalamic Neuropeptide Orexin/Hypocretin [PDF]
, 2013 2013-02Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators ...
YAMANAKA, AKIHIRO, INUTSUKA, AYUMU
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Journal of Pharmacological SciencesThe orexin system has been demonstrated to play various physiological roles, such as in feeding, sleep, and autonomic neural function. Clinically, orexin receptor antagonists are used as hypnotics, and several clinical trials have suggested their ...
Kazune Ozaki +6 more
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Orexin neurons receive glycinergic innervations. [PDF]
PLoS ONE, 2011 Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood.
Mari Hondo +4 more
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