Results 31 to 40 of about 18,205 (239)
Orexin/hypocretin role in reward: implications for opioid and other addictions
, 2017 Addiction is a devastating disorder that affects 15.3 million people worldwide. While prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential target for anti-craving medications.
邱麗珠 +1 more
core +2 more sources
European Journal of Histochemistry, 2009 The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques.
C Dall’Aglio +6 more
doaj +1 more source
The Regulation of Sleep and Wakefulness by the Hypothalamic Neuropeptide Orexin/Hypocretin [PDF]
, 2013 2013-02Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators ...
YAMANAKA, AKIHIRO, INUTSUKA, AYUMU
core +1 more source
Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study
BMC Research Notes, 2022 Objective Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection.
Yasuhiro Ogawa +5 more
doaj +1 more source
Roles of orexin in modulating arousal, feeding and motivation
Frontiers in Behavioral Neuroscience, 2013 Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Natsuko eTsujino, Takeshi eSakurai
doaj +1 more source
Orphanet Journal of Rare Diseases, 2020 Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi +13 more
doaj +1 more source
Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal
Frontiers in Neuroscience, 2021 The lateral hypothalamus (LH) is classically implicated in sleep-wake control. It is the main source of orexin/hypocretin and melanin-concentrating hormone (MCH) neuropeptides in the brain, which have been both implicated in arousal state switching ...
Cristina Concetti, Denis Burdakov
doaj +1 more source
Interactions between Lateral Hypothalamic Orexin and Dorsal Raphe Circuitry in Energy Balance
Brain SciencesOrexin/hypocretin terminals innervate the dorsal raphe nucleus (DRN), which projects to motor control areas important for spontaneous physical activity (SPA) and energy expenditure (EE).
Vijayakumar Mavanji +3 more
doaj +1 more source
, 2017 The orexin system consists of orexin A/hypocretin 1 and orexin B/hypocretin 2, and OX1 and OX2 receptors. Our previous electrophysiological study showed that orexin A in the rat ventrolateral periaqueductal gray (vlPAG) induced antinociception via an OX1
邱麗珠 +1 more
core +1 more source
Design and synthesis of orexin 1 receptor-selective agonists
, 2022 Orexins are a family of neuropeptides that regulate various physiological events such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., the orexin 1 (OX1R) and orexin 2 receptors (OX2R).
Yasuyuki, Nagumo +11 more
core +1 more source