Frontiers in Physiology, 2022 Orexins are neuropeptides originating from the hypothalamus that serve broad physiological roles, including the regulation of autonomic function, sleep-wake states, arousal and breathing.
Adrienn G. Varga +6 more
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A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value [PDF]
, 2007 Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which clusters AMPA receptors and regulates excitatory synaptogenesis. Although Narp is selectively enriched in brain, its role in behavior is not known.
Baraban, Jay M +6 more
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Orexin A activates retrotrapezoid neurons in mice [PDF]
Respiratory Physiology & Neurobiology, 2011 The retrotrapezoid nucleus (RTN), located at the ventral surface of the medulla oblongata, contains glutamatergic Phox2b-expressing interneurons that have central respiratory chemoreceptor properties. RTN also operates as a relay for hypothalamic pathways that regulate breathing, one of which probably originates from the orexinergic neurons (Dias et al.
Roman M, Lazarenko +3 more
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Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
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Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]
, 2019 CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P. +7 more
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ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal [PDF]
, 2010 Active neurons have a high demand for energy substrate, which is thought to be mainly supplied as lactate by astrocytes. Heavy lactate dependence of neuronal activity suggests that there may be a mechanism that detects and controls lactate levels and/or ...
Hirasawa, Michiru, Parsons, Matthew P.
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Pattern of Orexin Expression and Direct Biological Actions of Orexin-A in Rat Testis [PDF]
Endocrinology, 2005 Orexins, hypothalamic neuropeptides initially involved in the control of food intake and sleep-wake cycle, have recently emerged as pleiotropic regulators of different biological systems, including the reproductive axis. Besides central actions, peripheral expression and functions of orexins have been reported, and prepro-orexin and orexin type-1 ...
M L, Barreiro +12 more
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Orexin-A exerts equivocal role in atherosclerosis process depending on the duration of exposure : in vitro study [PDF]
, 2019 Orexin-A is a peptide hormone that plays a crucial role in feeding regulation and energy homeostasis. Diurnal intermittent fasting (DIF) has been found to increase orexin-A plasma levels during fasting hours, while Ramadan fasting which resembles DIF ...
Daskalopoulou, Aphrodite +9 more
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Orexin/hypocretin receptor signalling: a functional perspective [PDF]
British Journal of Pharmacology, 2013 Multiple homeostatic systems are regulated by orexin (hypocretin) peptides and their two known GPCRs. Activation of orexin receptors promotes waking and is essential for expression of normal sleep and waking behaviour, with the sleep disorder narcolepsy resulting from the absence of orexin signalling.
C S, Leonard, J P, Kukkonen
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Sleep Disorders and Genes [PDF]
, 2019 Versão preprintThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle.
Amici +101 more
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