Results 1 to 10 of about 13,145 (199)

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Psychopharmacology, 2001
Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine ...
Declan N C Jones, A Johns, R A Porter
exaly   +3 more sources

Radioimmunoassay for orexin A

Life Sciences, 2000
A radioimmunoassay for orexin A has been developed. Anti-orexin A antiserum was raised in New Zealand white rabbits immunized with a conjugate of synthetic orexin A with bovine serum albumin. This antibody did not crossreact with orexin B, hypothalamic hormones, pituitary hormones, neuropeptides or gut hormones.
T, Mitsuma, Y, Hirooka, M, Kayama, Y, Mori, Y, Yokoi, N, Rhue, J, Ping, M, Izumi, R, Ikai, K, Adachi, T, Nogimori   +10 more
openaire   +2 more sources

Localization of orexin A and orexin B in the porcine uterus

Reproductive Biology, 2012
The presence of orexins and their receptors in gonads indicate that these hormones participate in the control of reproductive functions. The aim of the study was to compare the expression of the prepro-orexin (PPO) gene in porcine endometrium and myometrium and the intensity of OXA- and OXB-immunoreactivity in the following uterine structures ...
Anna, Nitkiewicz, Nina, Smolinska, Anna, Maleszka, Marta, Kiezun, Tadeusz, Kaminski   +4 more
openaire   +2 more sources

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang, Richard M, Söll, Franz, Dürrenberger, Frank M, Dautzenberg, Annette G, Beck-Sickinger   +4 more
openaire   +2 more sources

Orexins and orexin receptors: implication in feeding behavior

Regulatory Peptides, 1999
Orexin-A and -B are initially identified as endogenous ligands for an orphan G protein coupled receptor. Since the discovery of orexins, investigations of their functions have been guided by their distribution in the lateral hypothalamic area, which has been implicated in feeding behavior.
openaire   +2 more sources

[Orexins and orexin receptors].

Ceskoslovenska fysiologie, 1999
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. Two novel neuropeptides Orexin -A and -B were identified. Orexins activate two closely related G protein-coupled receptors and stimulate food consumption. They act also as mediators in the central feedback mechanism and regulates feeding behavior.
K, Kotaska, R, Průsa
openaire   +1 more source

Glutamate and Orexin Neurons

2012
Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra, EYİGÖR, ÖZHAN, KAFA, İLKER MUSTAFA   +2 more
openaire   +3 more sources