Results 1 to 10 of about 16,909 (225)

Orexin receptors in GtoPdb v.2021.3. [PDF]

IUPHAR BPS Guide Pharm CITE, 2021
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [109 ...
Coleman P, de Lecea L, Gotter A, Hagan J, Hoyer D, Kilduff T, Kukkonen JP, Porter R, Renger J, Siegel JM, Sutcliffe G, Upton N, Winrow CJ.   +12 more
europepmc   +6 more sources

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Effects of a newly developed potent orexin-2 receptor-selective antagonist Compound1m on sleep/wake states in mice

Frontiers in Neuroscience, 2014
Orexins (also known as hypocretins), which are hypothalamic neuropeptides, play critical roles in the regulation of sleep/wakefulness states by activating two G-protein coupled receptors (GPCRs), orexin 1 (OX1R) and orexin 2 receptors (OX2R). In order to
Keishi eEtori, Yuki eSaito, Natsuko eTsujino, Takeshi eSakurai   +3 more
doaj   +1 more source

The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. [PDF]

PLoS One, 2022
Cook C, Nunn N, Worth AA, Bechtold DA, Suter T, Gackeheimer S, Foltz L, Emmerson PJ, Statnick MA, Luckman SM.   +9 more
europepmc   +1 more source

Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behaviour in alcohol-dependent rats. [PDF]

Br J Pharmacol, 2023
Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R.   +6 more
europepmc   +1 more source

Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala. [PDF]

Neuropharmacology, 2022
Yaeger JDW, Krupp KT, Summers TR, Summers CH.   +3 more
europepmc   +1 more source

In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors. [PDF]

Front Neurosci, 2021
Kim HJJ, Zagzoog A, Smolyakova AM, Ezeaka UC, Benko MJ, Holt T, Laprairie RB.   +6 more
europepmc   +1 more source

Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice

Iranian Journal of Allergy, Asthma and Immunology, 2016
Orexin A and B are hypothalamic peptides with a wide variety of effects such as anti-inflammation and neuroprotection. Impaired function of orexin system has been reported in some neurodegenerative diseases like Parkinson, Huntington and Alzheimer.
Iman Fatemi, Ali Shamsizadeh, Ali Roohbakhsh, Fatemeh Ayoobi, Mohammad Hossein Sanati, Manijeh Motevalian   +5 more
doaj  

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. [PDF]

Nat Commun, 2021
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC.   +14 more
europepmc   +1 more source