Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control [PDF]
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
doaj +3 more sources
No evidence of autoimmunity to human OX1 or OX2 orexin receptors in Pandemrix-vaccinated narcoleptic children [PDF]
Journal of Translational Autoimmunity, 2020 Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02.
Krister Melén +9 more
doaj +2 more sources
Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection. [PDF]
Clin Sci (Lond), 2018 Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart ...
Patel VH +12 more
europepmc +8 more sources
Paired-pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala [PDF]
Basic and Clinical Neuroscience, 2021 Introduction: The Basolateral Amygdala (BLA) substantially affects neuronal transmission and synaptic plasticity processes through the dentate gyrus. Orexin neuropeptides play different roles in the sleep/wakefulness cycle, feeding, learning, and memory.
Esmaeil Akbari +2 more
doaj +2 more sources
Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity. [PDF]
PLoS ONE, 2017 Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties.
Ainoleena Turku +5 more
doaj +5 more sources
The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications [PDF]
Frontiers in PharmacologyThe orexin (hypocretin) system, composed of the neuropeptides orexin A and orexin B and their receptors OX1R and OX2R, is primarily known for its role in sleep–wake regulation and energy homeostasis.
Daniel Stránský +4 more
doaj +2 more sources
In Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor‐Mediated Signaling [PDF]
Pharmacology Research & PerspectivesThe co‐expression of different types of G protein‐coupled receptors (GPCRs) in the same cells can have implications for receptor signaling and receptor cross‐talk, potentially altering the apparent potency or efficacy of ligands targeting each receptor ...
Kawthar A. Mohamed, Robert B. Laprairie
doaj +2 more sources
Beyond traditional sleeping pills: safety, efficacy and multidisease potential of three approved orexin receptor antagonists [PDF]
Frontiers in PsychiatryThis is a narrative review aiming to summarize the latest research progress of orexin receptor antagonists in insomnia treatment. To review the latest research progress on orexin receptor antagonists in the treatment of sleep disorders and explore their ...
Zening Yang, Chenshuo Jia, Zhizhao Ma
doaj +2 more sources
Orexin Signaling: A Complex, Multifaceted Process
Frontiers in Cellular Neuroscience, 2022 The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale +16 more
doaj +1 more source
Research progress of orexin on the regulation of cardiovascular activities [PDF]
Jichu yixue yu linchuang, 2023 Orexin(OX) is a neuropeptide mainly released by the hypothalamus. In the central nervous system, orexin neurons form extensive connections with other neuronal nuclei and participate in energy metabolism, sleep cycle and cardiovascular activity regulation.
ZHU Minxia
doaj +1 more source