Results 21 to 30 of about 549,398 (188)

Tumor cell apoptosis mediated by the orexins

Медицинская иммунология, 2021
Orexins A and B are neuropeptides synthesized by a population of lateral hypothalamic neurons. Orexin’s physiological function consists mainly in regulating the sleep-wake cycle, eating behavior, and energy homeostasis. Axons of orexin-containing neurons
A. S. Diatlova, N. S. Novikova, K. Z. Derevtsova, E. A. Korneva   +3 more
doaj   +1 more source

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
Herczeg, László, László Herczeg, Csilla S Molnár, Péter Gergely, Hrabovszky Erik, Borsay, Beáta Á., Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky, Gergely Péter, Borsay Beáta Á., Gergely, Péter, Liposits Zsolt, Molnár, Csilla S., Zsolt Liposits, Molnár Csilla S., Beáta Á Borsay, Herczeg László   +17 more
core   +3 more sources

Orexin, cardio-respiratory function and hypertension

Frontiers in Neuroscience, 2014
In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj   +1 more source

The orexin story and orexin receptor antagonists for the treatment of insomnia

Journal of Sleep Research, 2023
SummaryInsomnia is present in up to one third of the adult population worldwide, and it can present independently or with other medical conditions such as mental, metabolic, or cardiovascular diseases, which highlights the importance of treating this multifaceted disorder. Insomnia is associated with an abnormal state of hyperarousal (increased somatic,
Clemens Muehlan, Catherine Roch, Cedric Vaillant, Jasper Dingemanse   +3 more
openaire   +2 more sources

Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal

Frontiers in Neuroscience, 2021
The lateral hypothalamus (LH) is classically implicated in sleep-wake control. It is the main source of orexin/hypocretin and melanin-concentrating hormone (MCH) neuropeptides in the brain, which have been both implicated in arousal state switching ...
Cristina Concetti, Denis Burdakov
doaj   +1 more source

Integrative Physiology of Orexins and Orexin Receptors

CNS & Neurological Disorders - Drug Targets, 2009
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire   +3 more sources

Orexin receptors in GtoPdb v.2023.1 [PDF]

, 2023
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor ...
de Lecea, Luis, Jacobson, Laura, Hartman, Debbie, Sakurai, Takeshi, Upton, Neil, Hoyer, Daniel, Renger, John, Winrow, Christopher J., Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Bonaventure, Pascal, Coleman, Paul, Sutcliffe, Gregor, McDonald, Terrence P., Aston-Jones, Gary   +17 more
core   +1 more source

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Frontiers in Endocrinology, 2013
Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis.
Michihiro eMieda, Natsuko eTsujino, Takeshi eSakurai   +2 more
doaj   +1 more source

A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia

npj Genomic Medicine, 2022
Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is poorly ...
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda   +43 more
doaj   +1 more source

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Pharmaceuticals, 2017
Orexins/hypocretins are neuropeptides formed by proteolytic cleavage of a precursor peptide, which are produced by neurons found in the lateral hypothalamus. The G protein-coupled receptors (GPCRs) for these ligands, the OX1 and OX2 orexin receptors, are
Miles D. Thompson, Takeshi Sakurai, Innocenzo Rainero, Mary C. Maj, Jyrki P. Kukkonen   +4 more
doaj   +1 more source