Results 21 to 30 of about 9,891 (221)
Multiple signaling pathways of orexin receptors. [PDF]
Springerplus, 2015 Orexin/hypocretin peptides are central for the regulation of the sleep/arousal states, and have, in addition, a role in the regulation of e.g. metabolism, addiction, stress response and pain gating. Orexin responses are mediated by G-protein-coupled OX1 and OX2 orexin receptors. Orexin signaling (in different cell types) is very versatile, ranging from
Kukkonen J.
europepmc +3 more sources
Research progress of orexin on the regulation of cardiovascular activities [PDF]
Jichu yixue yu linchuang, 2023 Orexin(OX) is a neuropeptide mainly released by the hypothalamus. In the central nervous system, orexin neurons form extensive connections with other neuronal nuclei and participate in energy metabolism, sleep cycle and cardiovascular activity regulation.
ZHU Minxia
doaj +1 more source
The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]
PLoS ONE, 2014 This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta +9 more
doaj +1 more source
Orexins and Their Receptors in the Human Retina [PDF]
Pathobiology, 2004 <i>Objectives:</i> Orexins A and B are neuropeptides involved in the regulation of feeding behavior, energy homeostasis and arousal. In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained.
Savaskan, E +4 more
openaire +3 more sources
Experimental Gerontology, 2023 Aging is related to a variety of physiological organ changes, including central and peripheral nervous systems. It has been reported that the orexin signaling has a potential analgesic effect in different models of pain, especially inflammatory pulpal ...
Shima Torkzadeh-Mahani +5 more
doaj +1 more source
Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. [PDF]
PLoS ONE, 2017 Orexin-A and -B are hypothalamic neuropeptides of 33 and 28-amino acids, which regulate many homeostatic systems including sleep/wakefulness states, energy balance, energy homeostasis, reward seeking and drug addiction.
Anne Blais +6 more
doaj +1 more source
Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
openaire +2 more sources
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
, 2023 Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy.
Rosalba, Sortino +10 more
core +1 more source
Tumor cell apoptosis mediated by the orexins
Медицинская иммунология, 2021 Orexins A and B are neuropeptides synthesized by a population of lateral hypothalamic neurons. Orexin’s physiological function consists mainly in regulating the sleep-wake cycle, eating behavior, and energy homeostasis. Axons of orexin-containing neurons
A. S. Diatlova +3 more
doaj +1 more source
Orexin, cardio-respiratory function and hypertension
Frontiers in Neuroscience, 2014 In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj +1 more source