Results 31 to 40 of about 549,398 (188)
Presence of orexin A and orexin 1 receptor in the buffalo prostate
Italian Journal of Animal Science, 2010 The orexins A and B are two peptides discovered initially in the rat lateral hypothalamus involved in the regulation of some body functions such as food intake, sleep/wake cycle, arterial pressure and heart rate. They interact with two receptors defined &
A. Vittoria, F. Russo, G. Petrosino
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Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. [PDF]
PLoS ONE, 2011 Orexins (OX-A, OX-B) are neuropeptides involved in the regulation of the sleep-wake cycle, feeding and reward, via activation of orexin receptors 1 and 2 (OX1R, OX2R).
David Duguay +5 more
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Journal of Ovarian Research, 2023 Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder without definitive treatments. Orexin and Substance-P (SP) neuropeptides can affect the ovarian steroidogenesis.
Somayeh Kouhetsani +2 more
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Frontiers in Cardiovascular Medicine, 2022 Takotsubo syndrome (TTS) is an acute heart failure syndrome. Emotional or physical stressors are believed to precipitate TTS, while the pathophysiological mechanism is not yet completely understood.
Rajna Knez +4 more
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library [PDF]
, 2021 Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors.
Jumpei, Horiuchi +18 more
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Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems
Brain Research Bulletin, 2022 Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces distressing fear memory intrusions, avoidance behaviors, hyperarousal/startle, stress responses and insomnia.
Gary B. Kaplan +2 more
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Orexin Receptor Antagonists [PDF]
Current Sleep Medicine Reports, 2017 This paper focuses on the role of orexin receptors in sleep as evidenced in recent preclinical and clinical work. Orexin A and B and their two receptors (OX1R and OX2R) play essential roles in arousal and sleep/wake regulation, addiction, and stress. The absence of orexin producing cells in the lateral hypothalamus or of orexins in the CSF results in ...
B.T. Shireman, M.A. Letavic
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Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies
Alexandria Journal of Medicine, 2015 Orexin receptors belong to the big family of G protein coupled receptors (GPCRs) that constitute the main targets in the modern pharmacological approaches.
Abdelaziz Ghanemi, Xintian Hu
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Pharmaceuticals, 2023 Insomnia is an important public health problem. The currently available treatments for insomnia can cause some adverse effects. Orexin receptors 1 (OX1R) and 2 (OX2R) are burgeoning targets for insomnia treatment. It is an effective approach to screening
Jia He +5 more
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Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]
Journal of Endocrinology, 2006 Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides;
J E, Digby +5 more
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