Results 31 to 40 of about 9,891 (221)

Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal

Frontiers in Neuroscience, 2021
The lateral hypothalamus (LH) is classically implicated in sleep-wake control. It is the main source of orexin/hypocretin and melanin-concentrating hormone (MCH) neuropeptides in the brain, which have been both implicated in arousal state switching ...
Cristina Concetti, Denis Burdakov
doaj   +1 more source

The orexin story and orexin receptor antagonists for the treatment of insomnia

Journal of Sleep Research, 2023
SummaryInsomnia is present in up to one third of the adult population worldwide, and it can present independently or with other medical conditions such as mental, metabolic, or cardiovascular diseases, which highlights the importance of treating this multifaceted disorder. Insomnia is associated with an abnormal state of hyperarousal (increased somatic,
Clemens Muehlan, Catherine Roch, Cedric Vaillant, Jasper Dingemanse   +3 more
openaire   +2 more sources

Integrative Physiology of Orexins and Orexin Receptors

CNS & Neurological Disorders - Drug Targets, 2009
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
Michihiro, Mieda, Takeshi, Sakurai
openaire   +2 more sources

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
Herczeg, László, László Herczeg, Csilla S Molnár, Péter Gergely, Hrabovszky Erik, Borsay, Beáta Á., Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky, Gergely Péter, Borsay Beáta Á., Gergely, Péter, Liposits Zsolt, Molnár, Csilla S., Zsolt Liposits, Molnár Csilla S., Beáta Á Borsay, Herczeg László   +17 more
core   +1 more source

A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia

npj Genomic Medicine, 2022
Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is poorly ...
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda   +43 more
doaj   +1 more source

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Pharmaceuticals, 2017
Orexins/hypocretins are neuropeptides formed by proteolytic cleavage of a precursor peptide, which are produced by neurons found in the lateral hypothalamus. The G protein-coupled receptors (GPCRs) for these ligands, the OX1 and OX2 orexin receptors, are
Miles D. Thompson, Takeshi Sakurai, Innocenzo Rainero, Mary C. Maj, Jyrki P. Kukkonen   +4 more
doaj   +1 more source

Orexin Receptor Antagonists [PDF]

Current Sleep Medicine Reports, 2017
This paper focuses on the role of orexin receptors in sleep as evidenced in recent preclinical and clinical work. Orexin A and B and their two receptors (OX1R and OX2R) play essential roles in arousal and sleep/wake regulation, addiction, and stress. The absence of orexin producing cells in the lateral hypothalamus or of orexins in the CSF results in ...
B.T. Shireman, M.A. Letavic
openaire   +3 more sources

Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. [PDF]

PLoS ONE, 2011
Orexins (OX-A, OX-B) are neuropeptides involved in the regulation of the sleep-wake cycle, feeding and reward, via activation of orexin receptors 1 and 2 (OX1R, OX2R).
David Duguay, Erika Bélanger-Nelson, Valérie Mongrain, Anna Beben, Armen Khatchadourian, Nicolas Cermakian   +5 more
doaj   +1 more source

Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems

Brain Research Bulletin, 2022
Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces distressing fear memory intrusions, avoidance behaviors, hyperarousal/startle, stress responses and insomnia.
Gary B. Kaplan, Gabrielle A. Lakis, Hryhoriy Zhoba   +2 more
doaj   +1 more source

Orexin antagonism and substance-P: Effects and interactions on polycystic ovary syndrome in the wistar rats

Journal of Ovarian Research, 2023
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder without definitive treatments. Orexin and Substance-P (SP) neuropeptides can affect the ovarian steroidogenesis.
Somayeh Kouhetsani, Homayoun Khazali, Hassan Rajabi-Maham   +2 more
doaj   +1 more source