Results 41 to 50 of about 9,891 (221)

Orexin/hypocretin system dysfunction in patients with Takotsubo syndrome: A novel pathophysiological explanation

Frontiers in Cardiovascular Medicine, 2022
Takotsubo syndrome (TTS) is an acute heart failure syndrome. Emotional or physical stressors are believed to precipitate TTS, while the pathophysiological mechanism is not yet completely understood.
Rajna Knez, Rajna Knez, Rajna Knez, Milan Niksic, Elmir Omerovic   +4 more
doaj   +1 more source

Orexin receptors in GtoPdb v.2023.1

, 2023
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor ...
de Lecea, Luis, Jacobson, Laura, Hartman, Debbie, Sakurai, Takeshi, Upton, Neil, Hoyer, Daniel, Renger, John, Winrow, Christopher J., Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Bonaventure, Pascal, Coleman, Paul, Sutcliffe, Gregor, McDonald, Terrence P., Aston-Jones, Gary   +17 more
core   +1 more source

Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies

Alexandria Journal of Medicine, 2015
Orexin receptors belong to the big family of G protein coupled receptors (GPCRs) that constitute the main targets in the modern pharmacological approaches.
Abdelaziz Ghanemi, Xintian Hu
doaj   +1 more source

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library

, 2021
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors.
Jumpei, Horiuchi, Yasuyuki, Nagumo, Ryuichiro, Oshita, Hiroaki, Gouda, Yukiko, Ishikawa, Yasuo, Uchida, Tetsu, Sato, Hiroshi, Nagase, Tsuyoshi , Saitoh, Akihisa, Tokuda, Takeshi, Sakurai, Noriki, Kutsumura, Masashi, Yanagisawa, Mao, Amezawa, Yasuhiro, Ogawa, Naoshi, Yamamoto, Ryuji, Tanimura, Emi, Hasegawa, Yoko, Irukayama-Tomobe   +18 more
core   +1 more source

Orexins and male reproduction

Asian Pacific Journal of Reproduction, 2019
Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong
Pallav Sengupta, Sulagna Dutta, Maiza Tusimin, Ivan Rolland Karkada   +3 more
doaj   +1 more source

Research progress on the mechanism of orexin in pain regulation in different brain regions

Open Life Sciences, 2021
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui, Tang Hongli, Liu Yao, Yuan Yan, Wang Mi   +4 more
doaj   +1 more source

Ionic Mechanisms Underlying the Excitatory Effect of Orexin on Rat Subthalamic Nucleus Neurons

Frontiers in Cellular Neuroscience, 2019
Central orexinergic system deficiency results in cataplexy, a motor deficit characterized with a sudden loss of muscle tone, highlighting a direct modulatory role of orexin in motor control.
Guang-Ying Li, Qian-Xing Zhuang, Xiao-Yang Zhang, Jian-Jun Wang, Jing-Ning Zhu   +4 more
doaj   +1 more source

Stapled truncated orexin peptides as orexin receptor agonists

Peptides, 2018
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity.
Karhu, L, Weisell, J, Turunen, PM, Leino, TO, Pätsi, H, Xhaard, H, Kukkonen, JP, Wallén, EAA   +7 more
openaire   +5 more sources

Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]

PLoS ONE, 2011
At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam, Kwan-Wa Lau, Leo T O Lee, Jessica Y S Chu, Kwong-Man Ng, Alain Fournier, Hubert Vaudry, Billy K C Chow   +7 more
doaj   +1 more source

Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors [PDF]

Frontiers in Neuroscience, 2013
Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can predict contributing factors such as duration of action and undesirable effects.
Callander, GE, Olorunda, M, Monna, D, Schuepbach, E, Langenegger, D, Betschart, C, Hintermann, S, Behnke, D, Cotesta, S, Fendt, M, Laue, G, Ofner, S, Briard, E, Gee, CE, Jacobson, LH, Hoyer, D   +15 more
openaire   +3 more sources