Results 61 to 70 of about 9,891 (221)
Orexin/hypocretin role in reward: implications for opioid and other addictions
, 2017 Addiction is a devastating disorder that affects 15.3 million people worldwide. While prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential target for anti-craving medications.
邱麗珠 +1 more
core +1 more source
Interactions between Lateral Hypothalamic Orexin and Dorsal Raphe Circuitry in Energy Balance
Brain SciencesOrexin/hypocretin terminals innervate the dorsal raphe nucleus (DRN), which projects to motor control areas important for spontaneous physical activity (SPA) and energy expenditure (EE).
Vijayakumar Mavanji +3 more
doaj +1 more source
Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Brain Sciences, 2022 Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
doaj +1 more source
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background Little is known about substitution of alternative medications in the context of deprescribing. The objectives were to: (1) determine the frequency of medication substitutions among those who discontinued a central nervous system (CNS)‐active medication, and (2) characterize substitutions as potentially inappropriate (as per the 2023
Shelly L. Gray +6 more
wiley +1 more source
Animal, 2015 Orexin A and B are hypothalamic peptides derived from the prepro-orexin (PPO) precursor. Orexins stimulate food intake and arousal. Those peptides bind and activate two G protein-coupled receptors: orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R ...
N. Smolinska +5 more
doaj +1 more source
Orexin enhances firing activities of neurons in neonatal rat sublaterodorsal tegmental nucleus
Di-san junyi daxue xuebao, 2020 Objective To investigate the effect and underlying mechanism of orexin in modulating the firing activties of sublaterodorsal tegmental nucleus (SLD) neurons and its possible role in mediating rapid eye movement (REM) sleep regulation.
WEN Siyi +5 more
doaj +1 more source
Role of orexin receptors in histamine- and chloroquine-induced pruriceptive processing
Neuroscience ResearchIt is known that orexin peptides are involved in nociceptive processing, while little is known about the roles of these peptides in itch processing. To reveal the functions of orexin peptides in pruriceptive processing, orexin A (OX-A) and orexin B (OX-B)
Anna Kanemaru-Kawazoe +7 more
doaj +1 more source
Frontiers in Neuroscience, 2018 Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the dorsal raphe nucleus (DR) both play important roles in the regulation of sleep/wakefulness states, and show similar firing patterns ...
Yuki C. Saito +9 more
doaj +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann +13 more
wiley +1 more source
Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway
Frontiers in Neuroscience, 2023 BackgroundFocal motor seizures that originate in the motor region are a considerable challenge because of the high risk of permanent motor deficits after resection.
Tao Xue +10 more
doaj +1 more source