Results 81 to 90 of about 9,891 (221)

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line. [PDF]

PLoS ONE, 2017
The orexins and their cognate G-protein coupled receptors have been widely studied due to their associations with various behaviors and cellular processes.
Eric Koesema, Thomas Kodadek
doaj   +1 more source

Lights On or Off? The Efficacy of Light Therapy as Add‐On to Cognitive Behavioural Therapy for Insomnia—A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT Cognitive behavioural therapy for insomnia (CBT‐I) is recommended as first‐line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study investigates the therapeutic potential of light therapy as an add‐on to CBT‐I.
Sarah R. Schmid, Christine Blume, Johanna Ell, Nikolas Konzen, Matthias Apweiler, Bernd Feige, Bernd L. Fiebich, Julian E. Schiel, Katharina Domschke, Kai Spiegelhalder   +9 more
wiley   +1 more source

Orexin/hypocretin receptor signalling cascades [PDF]

British Journal of Pharmacology, 2013
Orexin (hypocretin) peptides and their two known G‐protein‐coupled receptors play essential roles in sleep–wake control and powerfully influence other systems regulating appetite/metabolism, stress and reward. Consequently, drugs that influence signalling by these receptors may provide novel therapeutic opportunities for treating sleep disorders ...
J P, Kukkonen, C S, Leonard
openaire   +2 more sources

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

, 2008
\ud RATIONALE:\ud \ud Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking.
Stephanie L. Borgland, Pia Steensland, Taha, Sharif, Steensland, Pia, Jeffrey A. Simms, Sharif A. Taha, Selena E. Bartlett, Richards, Jemma, Bonci, Antonello, Bartlett, Selena, Borgland, Stephanie, Jemma K. Richards, Antonello Bonci, Simms, Jeffrey   +13 more
core   +1 more source

Post‐ICU Psychotropic Medication Initiation in Nonagenarian Sepsis Survivors

Journal of the American Geriatrics Society, EarlyView.
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki   +2 more
wiley   +1 more source

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Ken-ichi Yagami, Bernard Bettler, Thomas Kilduff, Satoshi Kunita, Hitomi Takahira, Taizo Matsuki, Mika Nomiyama, Takeshi Sakurai, Noriko Hirashima, Satoru Takahashi, Masashi Yanagisawa   +10 more
core  

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization

, 2011
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2011 Spandidos Publications Ltd.A vital function of the human placenta is to produce steroid hormones such as ...
Karteris, E, Zachariades, E, Foster, H, Goumenou, A, Thomas, P, Rand-Weaver, M, null Karteris   +6 more
core   +1 more source