Results 81 to 90 of about 549,398 (188)

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

Orexin/hypocretin role in reward: implications for opioid and other addictions

, 2017
Addiction is a devastating disorder that affects 15.3 million people worldwide. While prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential target for anti-craving medications.
邱麗珠, Baimel, Corey;Bartlett, Selena E.;Chiou, Lih-Chu;Lawrence, Andrew J.;Muschamp, John W.;Patkar, Omkar;Tung, Li-Wei;Borgland, Stephanie L.   +1 more
core   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Orexin receptors in GtoPdb v.2025.3 [PDF]

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [79]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, prepro-
de Lecea, Luis, Sakurai, Takeshi, Hartman, Debbie, Upton, Neil, Winrow, Christopher J., Renger, John, Hoyer, Daniel, Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Sutcliffe, J. Gregor, Coleman, Paul, Bonaventure, Pascal, McDonald, Terrence P., Aston-Jones, Gary, Jacobson, Laura H.   +17 more
core   +1 more source

Respiratory safety of lemborexant in adult and elderly subjects with moderate‐to‐severe chronic obstructive pulmonary disease

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng, Daniel Lorch, Nancy Hall, Margaret Moline   +3 more
wiley   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Daridorexant‐ Case Report of Possible Side‐Effect in Rare Mitochondrial Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT This case report describes a 40‐year‐old woman with maternally inherited diabetes and deafness (MIDD), a rare mitochondrial disorder, who received treatment with daridorexant due to severe chronic insomnia. She developed progression of her MIDD symptoms during treatment.
Sven Svedmyr, Joel Bergqvist
wiley   +1 more source

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

The Journal of Physiology, EarlyView.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source

Localization of orexin B and orexin-2 receptor in the rat epididymis

Acta Histochemica, 2018
The peptides orexin A (OXA) and orexin B (OXB) derived from the proteolytic cleavage of a common precursor molecule, prepro-orexin, were originally described in the rat hypothalamus. Successively, they have been found in many other brain regions as well as in peripheral organs of mammals and other less evolved animals.
Giovanna Liguori, Simona Tafuri, Chika Miyoshi, Masashi Yanagisawa, Caterina Squillacioti, Valeria De Pasquale, Nicola Mirabella, Alfredo Vittoria, Anna Costagliola   +8 more
openaire   +4 more sources

Most Early‐Born Subplate Neurons Persist as Layer 6b Neurons in the Adult Mouse Neocortex

Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.
Comprehensive EdU birthdating and 3D volumetric analyses revealed that most early‐born subplate neurons (SpNs) persist into adulthood as layer 6b (L6b) neurons in the mouse neocortex. Green circles indicate SpNs/L6b neurons, and magenta labeling indicates EdU‐labeled early‐born neurons.
Yusuke Sugita, Keiko Moriya‐Ito, Carina Hanashima, Chiaki Ohtaka‐Maruyama   +3 more
wiley   +1 more source