Results 91 to 100 of about 549,398 (188)

Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods

Molecules, 2018
The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors.
Jana Janockova, Rafael Dolezal, Eugenie Nepovimova, Tereza Kobrlova, Marketa Benkova, Kamil Kuca, Jan Konecny, Eva Mezeiova, Michaela Melikova, Vendula Hepnarova, Avi Ring, Ondrej Soukup, Jan Korabecny   +12 more
doaj   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy

Frontiers in Neuroscience, 2013
Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by ...
Kristi A Kohlmeier, Christopher J Tyler, Mike eKalogiannis, Masaru eIshibashi, Morten P Kristensen, Iryna eGumenchuk, Richard M Chemelli, Yaz eKisanuki, Masashi eYanagisawa, Christopher S Leonard   +9 more
doaj   +1 more source

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Lights On or Off? The Efficacy of Light Therapy as Add‐On to Cognitive Behavioural Therapy for Insomnia—A Pilot Study

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Cognitive behavioural therapy for insomnia (CBT‐I) is recommended as first‐line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study investigates the therapeutic potential of light therapy as an add‐on to CBT‐I.
Sarah R. Schmid, Christine Blume, Johanna Ell, Nikolas Konzen, Matthias Apweiler, Bernd Feige, Bernd L. Fiebich, Julian E. Schiel, Katharina Domschke, Kai Spiegelhalder   +9 more
wiley   +1 more source

Orexin Receptors: Pharmacology and Therapeutic Opportunities

, 2011
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors.
Thomas E. Scammell, Christopher J. Winrow   +1 more
core   +1 more source

Differential Roles of Each Orexin Receptor Signaling in Obesity

iScience, 2019
Summary: Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here,
Miyo Kakizaki, Yousuke Tsuneoka, Kenkichi Takase, Staci J. Kim, Jinhwan Choi, Aya Ikkyu, Manabu Abe, Kenji Sakimura, Masashi Yanagisawa, Hiromasa Funato   +9 more
doaj   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Role of the Orexinergic System Within the Ventral Tegmental Area in the Development of Sensitization to Morphine Induced by Lateral Hypothalamus Stimulation

Basic and Clinical Neuroscience, 2022
Introduction: The Lateral Hypothalamus (LH) has long been known to implicate the addictive behaviors of drug abuse. The Ventral Tegmental Area (VTA) is a major area of the mesolimbic system that is strongly involved in developing morphine sensitization ...
Amir Haghparast, Mina Rashvand
doaj  

The G protein preference of orexin receptors is currently an unresolved issue. [PDF]

Nat Commun, 2023
Kukkonen JP.
europepmc   +1 more source