Results 101 to 110 of about 9,891 (221)

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A

, 2007
Presence of appetite-regulating peptides orexin-A and orexin-B in mucosal endocrine cells suggests a role in physiological control of the intestine. Our aim was to characterize orexin-induced stimulation of duodenal bicarbonate secretion and modulation ...
Sjöblom, Markus,, Bengtsson, Magnus W.,, Åkerman, Karl E. O.,, Flemström, Gunnar,, Herzig, Karl-Heinz, Mäkelä, Kari, Uotila, Sanna   +6 more
core   +1 more source

Signaling via Orexin Receptors : A Pharmacological Study

, 2004
The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation
Holmqvist, Tomas
core  

Differential Roles of Each Orexin Receptor Signaling in Obesity

iScience, 2019
Summary: Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here,
Miyo Kakizaki, Yousuke Tsuneoka, Kenkichi Takase, Staci J. Kim, Jinhwan Choi, Aya Ikkyu, Manabu Abe, Kenji Sakimura, Masashi Yanagisawa, Hiromasa Funato   +9 more
doaj   +1 more source

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

Epilepsia, Volume 67, Issue 6, Page 3108-3121, June 2026.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing, Lirong Han, Dongjun Guo, Thomas J. Foutz, Michael Wong   +4 more
wiley   +1 more source

Orexin receptors in GtoPdb v.2025.3

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [79]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, prepro-
de Lecea, Luis, Sakurai, Takeshi, Hartman, Debbie, Upton, Neil, Winrow, Christopher J., Renger, John, Hoyer, Daniel, Yanagisawa, Masashi, Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Sutcliffe, J. Gregor, Coleman, Paul, Bonaventure, Pascal, McDonald, Terrence P., Aston-Jones, Gary, Jacobson, Laura H.   +17 more
core   +1 more source

Role of the Orexinergic System Within the Ventral Tegmental Area in the Development of Sensitization to Morphine Induced by Lateral Hypothalamus Stimulation

Basic and Clinical Neuroscience, 2022
Introduction: The Lateral Hypothalamus (LH) has long been known to implicate the addictive behaviors of drug abuse. The Ventral Tegmental Area (VTA) is a major area of the mesolimbic system that is strongly involved in developing morphine sensitization ...
Amir Haghparast, Mina Rashvand
doaj  

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

The G protein preference of orexin receptors is currently an unresolved issue. [PDF]

Nat Commun, 2023
Kukkonen JP.
europepmc   +1 more source

El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]

, 2007
[spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core  

Distinct recognition of OX1 and OX2 receptors by orexin peptides.

, 2003
In this study, we have compared the abilities of orexin-A and orexin-B and variants of orexin-A to activate different Ca(2+) responses (influx and release) in human OX(1) and OX(2) receptor- expressing Chinese hamster ovary cells.
Ramin Shariatmadari, Hendrica B. Oonk, Sylwia Ammoun, Marc Parmentier, Detheux, Michel, Oonk, H.B., Oonk, Hendrica B., Shariatmadari, Ramin,, Holmqvist, Tomas, Oonk, Hendrica B, Akerman, Karl E, Kukkonen, J.P., Michel Detheux, Parmentier, Marc, Karl E. O. Åkerman, Kukkonen, Jyrki P.,, Kukkonen, Jyrki P, Holmqvist, T., Åkerman, Karl E. O.,, Detheux, M., Jyrki P. Kukkonen, Ammoun, S., Parmentier, M., Akerman, K.E.O., Ammoun, Sylwia,, Holmqvist, Tomas,, Shariatmadari, Ramin, Shariatmadari, R., Ammoun, Sylwia, Tomas Holmqvist   +29 more
core   +1 more source