Results 101 to 110 of about 549,398 (188)

Efeitos do bloqueio de receptores a1 do núcleo mediano da rafe sobre o comportamento alimentar e expressão da proteína Fos [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014A serotonina (5HT) é um neurotransmissor envolvido no controle da ingestão de ...
Silva, Eduardo Simão da
core  

Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor ...
de Lecea, Luis, Hagan, Jim, Upton, Neil, Gotter, Anthony, Renger, John, Winrow, Christopher J., Porter, Rod, Kilduff, Thomas, Kukkonen, Jyrki P., Siegel, Jerome M, Coleman, Paul, Sutcliffe, Gregor, Hills, Rebecca   +12 more
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Orexin regulates mitochondrial dynamics in avian muscle [PDF]

, 2015
The growing obesity epidemic has sparked numerous studies on the identification of molecular signatures that regulate energy homeostasis using different experimental animal models. Orexin, which acts via two G-protein coupled receptors, orexin receptor 1
Elizabeth Greene, Kentu Lassiter, Walter Bottje, Sami Dridi
core   +1 more source

Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices. [PDF]

Eur J Pharmacol, 2023
Kostansek JA, Latona GJ, Heruye SH, Matthews S, Bockman CS, Simeone KA, Simeone TA.   +6 more
europepmc   +1 more source

The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases

Frontiers in Molecular Neuroscience, 2018
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin ...
Chunmei Wang, Qinqin Wang, Bingyuan Ji, Yanyou Pan, Chao Xu, Baohua Cheng, Bo Bai, Jing Chen, Jing Chen   +8 more
doaj   +1 more source

Reply to: The G protein preference of orexin receptors is currently an unresolved issue. [PDF]

Nat Commun, 2023
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM.   +15 more
europepmc   +1 more source

A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers

SAGE Open Medicine, 2017
A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples.
Nicole L Graybill, Volkmar Weissig
doaj   +1 more source

The Orexin receptors: Structural and anti-tumoral properties. [PDF]

Front Endocrinol (Lausanne), 2022
Couvineau A, Nicole P, Gratio V, Voisin T.   +3 more
europepmc   +1 more source

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source

Research progress of narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal.
Fu-long XIAO, Jun ZHANG, Fang HAN
doaj