Results 121 to 130 of about 549,398 (188)

On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding

Medicine in Drug Discovery
Orexin receptor antagonists are on the market or under development for the treatment of insomnia and a number of other neuropsychiatric disorders. Currently, suvorexant, lemborexant and daridorexant, three dual orexin receptor antagonists (DORAs) have received market approval by regulatory authorities in the USA, Australia, Europe and/or Japan for the ...
Daniel Hoyer, Laura H. Jacobson
openaire   +3 more sources

A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging. [PDF]

Molecules, 2020
Bai P, Bai S, Placzek MS, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C.   +7 more
europepmc   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors. [PDF]

Acta Crystallogr F Struct Biol Commun
Mima M, Mishima-Tsumagari C, Sakata-Sakuta M, Iwaoka R, Iwamoto K.   +4 more
europepmc   +1 more source

Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus. [PDF]

Sci Rep
Krause GM, Chirich Barreira LM, Albrecht A.   +2 more
europepmc   +1 more source

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B. [PDF]

Cell Mol Life Sci
Prischich D, Sortino R, Gomila-Juaneda A, Matera C, Guardiola S, Nepomuceno D, Varese M, Bonaventure P, de Lecea L, Giralt E, Gorostiza P.   +10 more
europepmc   +1 more source

Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence. [PDF]

Front Integr Neurosci, 2020
Matzeu A, Martin-Fardon R.
europepmc   +1 more source

Mignot and Yanagisawa win Lasker prize for discovery of the role of orexins in wake, sleep, and narcolepsy. [PDF]

J Clin Invest
Saper CB.
europepmc   +1 more source

To sleep and dream: Unraveling narcolepsy. [PDF]

Proc Natl Acad Sci U S A
Friedman JM.
europepmc   +1 more source

Orexin Receptor Antagonist [PDF]

, 2020
openaire   +1 more source

Research Progress and Future Perspectives of Orexin Receptor Antagonists in Insomnia Therapy. [PDF]

Molecules
Zhang Z, Zhu L, Gao Y, Ji C, Ling Y.
europepmc   +1 more source