Results 1 to 10 of about 12,344 (239)

Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression [PDF]

EBioMedicine, 2017
Background: Neurophysiological and behavioral processes regulated by hypocretin (orexin) are severely affected in depression. However, alterations in hypocretin have so far not been studied in the human brain. We explored the hypocretin system changes in
Rolf Fronczek, Aimin Bao, Dick Swaab
exaly   +6 more sources

Hypocretin‐1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model

Advanced Science
Cognitive dysfunction is not only a common symptom of major depressive disorder, but also a more common residual symptom after antidepressant treatment and a risk factor for chronic and recurrent disease.
Jing Lu
exaly   +4 more sources

Hypocretin: a promising target for the regulation of homeostasis [PDF]

Frontiers in Neuroscience
Hypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states.
Yutong Wang, Yutong Wang, Su Fu, Jian Mao, Kun Cui, Hong Jiang, Hong Jiang   +6 more
doaj   +4 more sources

Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients

Frontiers in Psychiatry, 2021
As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders.
Haimei Li, Haimei Li, Haimei Li, Jing Lu, Jing Lu, Jing Lu, Shangda Li, Shangda Li, Shangda Li, Bochao Huang, Bochao Huang, Bochao Huang, Gongde Shi, Gongde Shi, Gongde Shi, Tingting Mou, Tingting Mou, Tingting Mou, Yi Xu, Yi Xu, Yi Xu, Yi Xu   +21 more
doaj   +2 more sources

Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

Cell Reports, 2023
Summary: The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and ...
Matthew Dawson, Dylan J. Terstege, Naila Jamani, Mio Tsutsui, Dmitrii Pavlov, Raluca Bugescu, Jonathan R. Epp, Gina M. Leinninger, Derya Sargin   +8 more
doaj   +2 more sources

Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain

Schizophrenia Bulletin, 2021
Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ).
Jing Lu, Rolf Fronczek, Aimin Bao
exaly   +2 more sources

Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy

Neurobiology of Disease, 2001
Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy.
Beth Ripley, Emmanuel Mignot, Seiji Nishino   +2 more
exaly   +3 more sources

Hypocretin (orexin) deficiency in human narcolepsy

Lancet, The, 2000
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.
Beth Ripley, Sebastiaan Overeem, Emmanuel Mignot   +2 more
exaly   +2 more sources

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Nature Communications, 2019
Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease ...
Tripti Tamhane, Poul Jennum, Henrik Ullum   +2 more
exaly   +2 more sources

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Nature Communications, 2019
T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and
Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins   +17 more
doaj   +2 more sources