Results 1 to 10 of about 5,951 (160)

Hypocretin: a promising target for the regulation of homeostasis [PDF]

Frontiers in Neuroscience
Hypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states.
Yutong Wang, Yutong Wang, Su Fu, Jian Mao, Kun Cui, Hong Jiang, Hong Jiang   +6 more
doaj   +2 more sources

Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression

EBioMedicine, 2017
Background: Neurophysiological and behavioral processes regulated by hypocretin (orexin) are severely affected in depression. However, alterations in hypocretin have so far not been studied in the human brain. We explored the hypocretin system changes in
Juan Zhao, Rawien Balesar, Rolf Fronczek   +2 more
exaly   +3 more sources

Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy

Neurobiology of Disease, 2001
Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy.
Beth Ripley, Nobuhiro Fujiki, Emmanuel Mignot   +2 more
exaly   +3 more sources

Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients

Frontiers in Psychiatry, 2021
As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders.
Haimei Li, Jing Lu, Shangda Li
exaly   +3 more sources

Hypocretin‐1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model

Advanced Science
Cognitive dysfunction is not only a common symptom of major depressive disorder, but also a more common residual symptom after antidepressant treatment and a risk factor for chronic and recurrent disease.
Kangyu Jin, Jingyi Dong, Lingzhuo Kong   +2 more
exaly   +2 more sources

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System [PDF]

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +2 more sources

Editorial: Hypocretins/Orexins

Frontiers in Endocrinology, 2020
Miguel López, Miguel López, Luis de Lecea, Carlos Diéguez, Carlos Diéguez   +4 more
doaj   +3 more sources

Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau, Sophie Bayard, Quentin Coquerel, Pierre Déchelotte, Christine Bole-Feysot, Bertrand Carlander, Valérie Cochen De Cock, Sergueï O Fetissov, Yves Dauvilliers   +8 more
doaj   +1 more source

Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes

Dementia and Geriatric Cognitive Disorders Extra, 2021
Background/Aims: Hypocretin promotes wakefulness and modulates REM sleep. Alterations in the hypocretin system are increasingly implicated in dementia.
Lynn Marie Trotti, Donald L. Bliwise, Glenda L. Keating, David B. Rye, William T. Hu   +4 more
doaj   +1 more source

The hypocretins and sleep [PDF]

The FEBS Journal, 2005
The hypocretins (also called the orexins) are two neuropeptides derived from the same precursor whose expression is restricted to a few thousand neurons of the lateral hypothalamus. Two G‐protein coupled receptors for the hypocretins have been identified, and these show different distributions within the central nervous system and differential ...
Luis, de Lecea, J Gregor, Sutcliffe
openaire   +2 more sources