Results 11 to 20 of about 12,344 (239)
IGFBP3 colocalizes with and regulates hypocretin (orexin). [PDF]
PLoS ONE, 2009 The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell ...
Makoto Honda +14 more
doaj +2 more sources
Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]
PLoS ONE, 2010 BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau +8 more
doaj +2 more sources
Orexin (hypocretin) and addiction
Trends in Neurosciences, 2021 Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior.
Jacqueline B. Mehr +2 more
semanticscholar +3 more sources
Hypocretin/orexin receptor pharmacology and sleep phases
Monographs in neural sciences, 2021 Executive summary The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R.
Yu Sun, Ryan K. Tisdale, T. Kilduff
semanticscholar +2 more sources
The Hypocretin System and Psychiatric Disorders
Current Psychiatry Reports, 2013 The hypocretin system is constituted by a small group of hypothalamic neurons with widespread connections within the entire central nervous system producing two neuropeptides involved in several key physiological functions such as the regulation of sleep and wakefulness, motor control, autonomic functions, metabolism, feeding behavior, and reward ...
PIZZA, FABIO +3 more
openaire +5 more sources
The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. [PDF]
PLoS ONE, 2012 Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was ...
Subhashini Srinivasan +8 more
doaj +3 more sources
Journal of Cellular and Molecular Medicine, 2019 Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF‐α) is an important neuroinflammation mediator. Here, we examined the effects of TNF‐α treatment on hypocretin expression in vivo and
Shuqin Zhan, Liyong Wu, Lynn Han
exaly +2 more sources
Cell Metabolism, 2018 SUMMARY We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed IL-6 mediated peripheral inflammation, coincident with altered hepatic glucose processing and ...
William Walker +2 more
exaly +2 more sources
Hypocretin as a Hub for Arousal and Motivation
Frontiers in Neurology, 2018 The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior.
Susan M. Tyree +2 more
doaj +2 more sources
El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]
, 2007 [spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core +6 more sources