Hypocretin‐1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model [PDF]
Advanced ScienceCognitive dysfunction is not only a common symptom of major depressive disorder, but also a more common residual symptom after antidepressant treatment and a risk factor for chronic and recurrent disease.
Kangyu Jin, Jing Lu
exaly +3 more sources
Hypocretin: a promising target for the regulation of homeostasis [PDF]
Frontiers in NeuroscienceHypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states.
Yutong Wang +6 more
doaj +2 more sources
Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression
EBioMedicine, 2017 Background: Neurophysiological and behavioral processes regulated by hypocretin (orexin) are severely affected in depression. However, alterations in hypocretin have so far not been studied in the human brain. We explored the hypocretin system changes in
Rolf Fronczek, Ai-Min Bao, Dick F Swaab
exaly +3 more sources
Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy
Neurobiology of Disease, 2001 Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy.
Beth Ripley +2 more
exaly +3 more sources
Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre [PDF]
Arquivos de Neuro-Psiquiatria, 2010 This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil. METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were ...
Fernando Morgadinho Santos Coelho +7 more
doaj +5 more sources
Effects of Traumatic Brain Injury on the Orexin/Hypocretin System [PDF]
Neurotrauma ReportsTraumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach +2 more
doaj +2 more sources
Hypocretin (Orexin) Replacement Therapies
Medicine in Drug Discovery, 2020 Twenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regulation, fear ...
Erica Seigneur, Luis de Lecea
doaj +3 more sources
Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study [PDF]
Frontiers in Aging NeuroscienceBackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke ...
Ting Fu +7 more
doaj +2 more sources
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship [PDF]
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
doaj +3 more sources
Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss. [PDF]
, 2017 The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method
McGregor, Ronald +3 more
core +8 more sources