Results 11 to 20 of about 8,767 (247)

IGFBP3 colocalizes with and regulates hypocretin (orexin). [PDF]

PLoS ONE, 2009
The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell ...
Makoto Honda, Krister S Eriksson, Shengwen Zhang, Susumu Tanaka, Ling Lin, Ahmad Salehi, Per Egil Hesla, Jan Maehlen, Stephanie E Gaus, Masashi Yanagisawa, Takeshi Sakurai, Shahrad Taheri, Kuniaki Tsuchiya, Yutaka Honda, Emmanuel Mignot   +14 more
doaj   +2 more sources

Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

Cell Reports, 2023
Summary: The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and ...
Matthew Dawson, Dylan J. Terstege, Naila Jamani, Mio Tsutsui, Dmitrii Pavlov, Raluca Bugescu, Jonathan R. Epp, Gina M. Leinninger, Derya Sargin   +8 more
doaj   +2 more sources

Hypocretin/orexin receptor pharmacology and sleep phases

Monographs in neural sciences, 2021
Executive summary The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R.
Yu Sun, Ryan K. Tisdale, T. Kilduff
semanticscholar   +2 more sources

Narcolepsy Type 1: Should We Only Target Hypocretin Receptor 2?

Clinical and Translational Neuroscience, 2023
Nearly 25 years have passed since the ground-breaking discovery that hypocretin deficiency underlies human narcolepsy with cataplexy. Over time, it has become increasingly evident that hypocretin deficiency goes beyond the conventional core symptoms, or ...
Rolf Fronczek, Gert Jan Lammers
doaj   +2 more sources

Heterogeneity of Hypocretin/Orexin Neurons [PDF]

Monographs in neural sciences, 2021
The multifunctional, hypothalamic hypocretin/orexin (HCRT)-producing neurons regulate an array of physiological and behavioral states including arousal, sleep, feeding, emotions, stress, and reward. How a presumably uniform HCRT neuron population regulates such a diverse set of functions is not clear.
Dana, Sagi, Luis, de Lecea, Lior, Appelbaum   +2 more
openaire   +3 more sources

The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. [PDF]

PLoS ONE, 2012
Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was ...
Subhashini Srinivasan, Jeffrey A Simms, Carsten K Nielsen, Steven P Lieske, Jade J Bito-Onon, Henry Yi, Frederic Woodward Hopf, Antonello Bonci, Selena E Bartlett   +8 more
doaj   +2 more sources

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Nature Communications, 2019
T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and
Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins   +17 more
doaj   +2 more sources

Hypocretin/orexin deficiency decreases cocaine abuse liability

Neuropharmacology, 2018
Compelling evidence indicates that hypocretin/orexin signaling regulates arousal, stress and reward-seeking behaviors. However, most studies on drug reward-related processes have so far described the effects of pharmacological blockers disrupting ...
N. Steiner, Clara Rossetti, T. Sakurai, M. Yanagisawa, L. de Lecea, P. Magistretti, O. Halfon, B. Boutrel   +7 more
semanticscholar   +2 more sources

Hypocretin as a Hub for Arousal and Motivation

Frontiers in Neurology, 2018
The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior.
Susan M. Tyree, Jeremy C. Borniger, Luis de Lecea   +2 more
doaj   +2 more sources

Increased Numbers of CD4⁺ T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1. [PDF]

Ann Neurol
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Shan L, Fonville M, Hoekstra M, Fronczek R, Smolders J, Swaab DF.   +5 more
europepmc   +2 more sources