Results 31 to 40 of about 8,767 (247)
Molecular Metabolism, 2023 Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA ...
Suraj B. Teegala +8 more
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The Orexins/Hypocretins and Schizophrenia [PDF]
Schizophrenia Bulletin, 2006 Advances in molecular biology have led to new peptides and proteins being discovered on a regular basis, including the isolation of a number of neurotransmitter candidates. Rarely, however, do these immediately capture the attention of the scientific community.
Ariel Y, Deutch, Michael, Bubser
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Hypocretin/Orexin, Sleep and Alzheimer's Disease.
Monographs in neural sciences, 2021 Advances in translational research provide key opportunities to explore the physiological and pathological effects of sleep in different neurodegenerative diseases.
Y. Dauvilliers
semanticscholar +1 more source
Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors.
Neuropharmacology, 2020 The neuropeptide hypocretin/orexin plays a broad and important role in physiological functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and homeostatic regulation.
F. Hopf
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Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Frontiers in Aging Neuroscience, 2014 Objective: To examine relationships between cerebrospinal fluid (CSF) Alzheimer’ disease (AD) biomarkers and hypocretin-1 levels in patients with cognitive abnormalities and hypocretin-deficient narcolepsy-cataplexy (NC), estimate diagnostic accuracy ...
Yves A Dauvilliers +4 more
doaj +1 more source
Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neurons. [PDF]
PLoS ONE, 2012 The central neural pathways underlying the physiological coordination between thermoregulation and the controls of the wake-sleep behavior and cardiovascular function remain insufficiently understood.
Viviana Lo Martire +4 more
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Cellular Signaling Mechanisms of Hypocretin/Orexin.
Monographs in neural sciences, 2021 Orexin receptors (OXRs) are promiscuous G-protein-coupled receptors that signal via several G-proteins and, putatively, via other proteins. On which basis the signal pathways are selected and orchestrated is largely unknown.
J. Kukkonen, Pauli M Turunen
semanticscholar +1 more source
Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
Frontiers in Behavioral Neuroscience, 2013 ajor advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy caused by the early loss of hypothalamic hypocretin neurons.
Sophie eBayard, Yves A Dauvilliers
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Frontiers in Systems Neuroscience, 2015 The neuronal system that resides in the perifornical and lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide hypocretin/orexin participates in critical brain functions across species from fish to human.
Xiao-Bing eGao, Gretchen eHermes
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, 2016 How the brain controls vigilance state transitions remains to be fully understood. The discovery of hypocretins, also known as orexins, and their link to narcolepsy has undoubtedly allowed us to advance our knowledge on key mechanisms controlling the boundaries and transitions between sleep and wakefulness.
Shi-Bin, Li +2 more
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