Results 31 to 40 of about 12,344 (239)
Progress of autonomic disturbances in narcolepsy type 1
Frontiers in Neurology, 2023 Narcolepsy type 1 is a kind of sleep disorder characterized by a specific loss of hypocretin neurons in the lateral hypothalamus and reduced levels of hypocretin-1 in the cerebrospinal fluid.
Ying Wang +6 more
doaj +1 more source
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Journal of Neuroscience, 1998 The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies in a subregion of the tuberal part of the hypothalamus.
C. Peyron +6 more
semanticscholar +1 more source
Heterogeneity of hypocretin/orexin neurons
Monographs in neural sciences, 2021 Executive summary The multi-functional, hypothalamic hypocretin/orexin (HCRT) producing neurons regulate an array of physiological and behavioral states including arousal, sleep, feeding, emotions, stress, and reward. How a presumably uniform HCRT neuron
Dana Sagi, L. de Lecea, L. Appelbaum
semanticscholar +1 more source
Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency.
Monographs in neural sciences, 2021 Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in the disorder, a gateway to understanding REM sleep.
E. Mignot +3 more
semanticscholar +1 more source
Narcolepsy with intermediate cerebrospinal level of hypocretin-1.
Sleep, 2021 STUDY OBJECTIVES To describe the phenotype of narcolepsy with intermediate cerebrospinal hypocretin-1 levels (CSF hcrt-1). METHODS From 1600 consecutive patients with narcolepsy from Bologna and Montpellier sleep centers we selected patients with ...
E. Postiglione +10 more
semanticscholar +1 more source
Molecular Metabolism, 2023 Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA ...
Suraj B. Teegala +8 more
doaj +1 more source
Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neurons. [PDF]
PLoS ONE, 2012 The central neural pathways underlying the physiological coordination between thermoregulation and the controls of the wake-sleep behavior and cardiovascular function remain insufficiently understood.
Viviana Lo Martire +4 more
doaj +1 more source
Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome
Journal of Neuroscience, 2021 We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons. However, it remains unknown how this increase affects target areas
R. McGregor +7 more
semanticscholar +1 more source
Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Frontiers in Aging Neuroscience, 2014 Objective: To examine relationships between cerebrospinal fluid (CSF) Alzheimer’ disease (AD) biomarkers and hypocretin-1 levels in patients with cognitive abnormalities and hypocretin-deficient narcolepsy-cataplexy (NC), estimate diagnostic accuracy ...
Yves A Dauvilliers +4 more
doaj +1 more source
Hypocretin/Orexin, Sleep and Alzheimer's Disease.
Monographs in neural sciences, 2021 Advances in translational research provide key opportunities to explore the physiological and pathological effects of sleep in different neurodegenerative diseases.
Y. Dauvilliers
semanticscholar +1 more source