Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
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Molecular Metabolism, 2023 Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA ...
Suraj B. Teegala +8 more
doaj +1 more source
Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle [PDF]
, 2013 This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionThe perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated in several physiological functions ...
Garzón, Miguel +3 more
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Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neurons. [PDF]
PLoS ONE, 2012 The central neural pathways underlying the physiological coordination between thermoregulation and the controls of the wake-sleep behavior and cardiovascular function remain insufficiently understood.
Viviana Lo Martire +4 more
doaj +1 more source
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]
, 2014 The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S +4 more
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DEC2 modulates orexin expression and regulates sleep. [PDF]
, 2018 Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait.
Fu, Ying-Hui +7 more
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Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Frontiers in Aging Neuroscience, 2014 Objective: To examine relationships between cerebrospinal fluid (CSF) Alzheimer’ disease (AD) biomarkers and hypocretin-1 levels in patients with cognitive abnormalities and hypocretin-deficient narcolepsy-cataplexy (NC), estimate diagnostic accuracy ...
Yves A Dauvilliers +4 more
doaj +1 more source
Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2". [PDF]
, 2015 Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et ...
Li, S., Tafti, M., Vassalli, A.
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Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
Frontiers in Behavioral Neuroscience, 2013 ajor advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy caused by the early loss of hypothalamic hypocretin neurons.
Sophie eBayard, Yves A Dauvilliers
doaj +1 more source
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
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