Results 51 to 60 of about 12,344 (239)

Polymorphisms in hypocretin receptors and insomnia

Sleep Science, 2013
Hypocretin system has been described as one of the most important neurotransmission systems involved in the waking process. The system’s lack of function, caused by mutation or neuron death, leads to sharp sleepiness in mammals. It has been proposed that
Lhoyane Moraes Oliveira, Sergio Tufik, Luciano Ribeiro Pinto, Silverio Garbuio, Lia Rita Bittencourt, Mario Pedrazzoli   +5 more
doaj   +1 more source

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study. [PDF]

PLoS ONE, 2015
The proper functioning of the mesolimbic reward system is largely dependent on the neurotransmitter dopamine. Recent evidence suggests that the hypocretin system has significant projections to this reward system.
Armand Mensen, Rositsa Poryazova, Gordana Huegli, Christian R Baumann, Sophie Schwartz, Ramin Khatami   +5 more
doaj   +1 more source

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System [PDF]

, 2002
Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse ...
Li, Ying, Sakurai, Takeshi, Gao, Xiao-Bing, van den Pol, Anthony N.   +3 more
core   +1 more source

Overview of orexin/ hypocretin system [PDF]

, 2012
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents.
60251055, Sakurai, Takeshi, 20296552, 259, Mieda, Michihiro, Michihiro Mieda, Takeshi Sakurai   +6 more
core   +1 more source

Hypocretins or hyporexins? [PDF]

Nature Medicine, 1998
Lettera
NISOLI E, CARRUBA MO, VALERIO, Alessandra, BORSANI, Giuseppe   +3 more
openaire   +3 more sources

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review

Cogent Medicine, 2017
The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci, Warwick Hosking, Dorothy Bruck   +2 more
doaj   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Effects of vivo morpholino knockdown of lateral hypothalamus orexin/hypocretin on renewal of alcohol seeking.

PLoS ONE, 2014
Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive ...
Asheeta A Prasad, Gavan P McNally
doaj   +1 more source

Hypocretin (Orexin) Replacement Therapies

Medicine in Drug Discovery, 2020
Twenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regulation, fear ...
Erica Seigneur, Luis de Lecea
doaj   +1 more source