Results 51 to 60 of about 8,767 (247)
Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review
Cogent Medicine, 2017 The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci +2 more
doaj +1 more source
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Nature Communications, 2020 Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad +4 more
doaj +1 more source
Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. [PDF]
PLoS ONE, 2017 Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results.
Marco Filardi +5 more
doaj +1 more source
The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease
Brain Pathology, EarlyView.SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery +17 more
wiley +1 more source
El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]
, 2007 [spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core
, 2014 The orexin/hypocretin synapse is shown including the synthesis of endogenous ligands, the application of synthetic antagonists and downstream signalling cascades of the orexin receptors.
Shaun Yon-Seng Khoo (459463)
core +1 more source
PLoS ONE, 2014 Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive ...
Asheeta A Prasad, Gavan P McNally
doaj +1 more source
Narcolepsy and rapid eye movement sleep
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini +4 more
wiley +1 more source
Science Translational Medicine, 2018 Heroin addiction is accompanied by an increase in detected hypocretin (orexin) neurons, and in narcoleptic mice deficient in these neurons, morphine can reverse cataplexy. Opiate addiction and narcolepsy: Opposite sides of the same coin? The neurological
Thomas C. Thannickal +14 more
semanticscholar +1 more source
Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund
Journal of Veterinary Internal Medicine, 2017 Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid +4 more
doaj +1 more source