Cluster headache: a quasi-rare disorder needing a reappraisal [PDF]
, 2015 Editoria
Martelletti, Paolo +1 more
core +1 more source
The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. [PDF]
PLoS ONE, 2012 Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was ...
Subhashini Srinivasan +8 more
doaj +1 more source
Hypocretin and Human African Trypanosomiasis [PDF]
Sleep, 2008 To detail clinical and polysomnographic characteristics in patients affected with Trypanosoma brucei gambiense (Tb.g.) human African trypanosomiasis (HAT) at different stages of evolution and to measure and compare cerebrospinal fluid (CSF) levels of hypocretin-1 with narcoleptic patients and neurologic controls.Twenty-five untreated patients affected ...
Yves, Dauvilliers +6 more
openaire +2 more sources
Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. [PDF]
, 2013 The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala ...
Behnke, Eric J +9 more
core +1 more source
Heterogeneity of Hypocretin/Orexin Neurons [PDF]
, 2021 The multifunctional, hypothalamic hypocretin/orexin (HCRT)-producing neurons regulate an array of physiological and behavioral states including arousal, sleep, feeding, emotions, stress, and reward. How a presumably uniform HCRT neuron population regulates such a diverse set of functions is not clear.
Dana, Sagi +2 more
openaire +2 more sources
Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons [PDF]
, 2017 We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification(TRAP). Here, we briefly report on the basic characterization of this mouse line including confirmation of expression of the transgene in midbrain
Dougherty, Joseph D
core +2 more sources
Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review
Cogent Medicine, 2017 The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci +2 more
doaj +1 more source
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Nature Communications, 2020 Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad +4 more
doaj +1 more source
PLoS ONE, 2014 Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive ...
Asheeta A Prasad, Gavan P McNally
doaj +1 more source
The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease
Brain Pathology, EarlyView.SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery +17 more
wiley +1 more source