Results 61 to 70 of about 12,344 (239)

Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future.

Sleep, 2020
Animal models have advanced not only our understanding of the etiology and phenotype of the sleep disorder narcolepsy but have also informed sleep/wake regulation more generally.
Ryan K. Tisdale, A. Yamanaka, T. Kilduff
semanticscholar   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre

Arquivos de Neuro-Psiquiatria, 2010
This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil. METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were ...
Fernando Morgadinho Santos Coelho, Márcia Pradella-Hallinan, Mario Pedrazzoli, Carlos Augusto Senne Soares, Gustavo Bruniera Peres Fernandes, André Leite Gonçalves, Sergio Tufik, Lia Rita Azeredo Bittencourt   +7 more
doaj   +1 more source

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Nature Communications, 2020
Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti   +4 more
doaj   +1 more source

Enhanced Visual Cortex Activation in People With Narcolepsy Type 1 During Active Sleep Resistance: An fMRI-EEG Study

Frontiers in Neuroscience, 2022
The brain activation patterns related to sleep resistance remain to be discovered in health and disease. The maintenance of wakefulness test (MWT) is an objective neuropsychological assessment often used to assess an individual’s ability to resist sleep.
Jari K. Gool, Jari K. Gool, Jari K. Gool, Jari K. Gool, Rolf Fronczek, Rolf Fronczek, Peter Bosma, Johan N. van der Meer, Ysbrand D. van der Werf, Ysbrand D. van der Werf, Gert Jan Lammers, Gert Jan Lammers   +11 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Progressive dopamine and hypocretin deficiencies in Parkinson's disease: is there an impact on sleep and wakefulness?

, 2012
Sleep-wake disturbances are frequent in patients with Parkinson's disease, but prospective controlled electrophysiological studies of sleep in those patients are surprisingly sparse, and the pathophysiology of sleep-wake disturbances in Parkinson's ...
Storch, Alexander, Weller, Michael, Bassetti, C L, Waldvogel, Daniel, Baumann-Vogel, H, Baumann, C R, Bassetti, Claudio L, Storch, A, Wienecke, Miriam, Wienecke, M, Weller, M, Werth, Esther, Baumann-Vogel, Heide, Baumann, Christian R, Poryazova, R, Waldvogel, D, Werth, E; https://orcid.org/, Poryazova, Rositsa   +17 more
core   +1 more source

Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy

Science Translational Medicine, 2018
Heroin addiction is accompanied by an increase in detected hypocretin (orexin) neurons, and in narcoleptic mice deficient in these neurons, morphine can reverse cataplexy. Opiate addiction and narcolepsy: Opposite sides of the same coin? The neurological
Thomas C. Thannickal, J. John, Shan Ling, D. Swaab, Ming-Fung Wu, Lalini Ramanathan, R. McGregor, Keng-Tee Chew, Marcia Cornford, A. Yamanaka, Ayumu Inutsuka, R. Fronczek, G. Lammers, P. Worley, J. Siegel   +14 more
semanticscholar   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source