Results 61 to 70 of about 13,161 (220)

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Enhanced Visual Cortex Activation in People With Narcolepsy Type 1 During Active Sleep Resistance: An fMRI-EEG Study

Frontiers in Neuroscience, 2022
The brain activation patterns related to sleep resistance remain to be discovered in health and disease. The maintenance of wakefulness test (MWT) is an objective neuropsychological assessment often used to assess an individual’s ability to resist sleep.
Jari K. Gool, Jari K. Gool, Jari K. Gool, Jari K. Gool, Rolf Fronczek, Rolf Fronczek, Peter Bosma, Johan N. van der Meer, Ysbrand D. van der Werf, Ysbrand D. van der Werf, Gert Jan Lammers, Gert Jan Lammers   +11 more
doaj   +1 more source

Orexin in the chicken hypothalamus: immunocytochemical localisation and comparison of mRNA concentrations during the day and night, and after chronic food restriction [PDF]

, 2013
In mammals Orexin-A and -B are neuropeptides involved in the hypothalamic regulation of diverse physiological functions including food intake and the sleep-wake cycle.
de Girolamo, Paolo, Dunn, Ian C, Esposito, Vincenzo, Miranda, Bernadette, Sharp, Peter J, Wilson, Peter W   +5 more
core   +1 more source

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

Narcolepsy and Cataplexy – a practical approach to diagnosis and managing the impact of this chronic condition on children and their families [PDF]

, 2017
Narcolepsy is a relatively common neurological condition affecting the regulation of normal sleep/wake cycles leading to excessive daytime sleepiness (EDS).
Blackwell, J, Elphick, H, Kingshott, R, Staniforth, T   +3 more
core   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Orexin/hypocretin receptor signalling cascades [PDF]

British Journal of Pharmacology, 2013
Orexin (hypocretin) peptides and their two known G‐protein‐coupled receptors play essential roles in sleep–wake control and powerfully influence other systems regulating appetite/metabolism, stress and reward. Consequently, drugs that influence signalling by these receptors may provide novel therapeutic opportunities for treating sleep disorders ...
J P, Kukkonen, C S, Leonard
openaire   +2 more sources

Narcolepsy Following Yellow Fever Vaccination: A Case Report [PDF]

, 2016
Narcolepsy with cataplexy is a rare, but important differential diagnosis for daytime sleepiness and atonic paroxysms in an adolescent. A recent increase in incidence in the pediatric age group probably linked to the use of the Pandemrix influenza ...
Deb K. Pal, Michael Farquhar, Paul Gringras, Richard E. Rosch   +3 more
core   +3 more sources

Overnight Dynamics of Ventricular Cerebrospinal Fluid Amyloid‐Beta, Lactate and Hypocretin in Patients With Hydrocephalus: A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid‐β42 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during ...
Casper Schwartz Riedel, Joachim Birch Milan, Niklas Rye Jørgensen, Poul Jennum, Marianne Juhler   +4 more
wiley   +1 more source