Results 71 to 80 of about 8,767 (247)

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Overview of orexin/ hypocretin system

, 2012
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents.
60251055, Sakurai, Takeshi, 20296552, 259, Mieda, Michihiro, Michihiro Mieda, Takeshi Sakurai   +6 more
core   +1 more source

Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I [PDF]

, 2021
The hypocretin/orexin system regulates arousal through central nervous system mechanisms and plays an important role in sleep, wakefulness and energy homeostasis.
Lorentzen, Marc P., Kornum, Birgitte R, Christensen, Gitte L., Pizza, Fabio, Jennum, Poul J., Plazzi, Giuseppe, Lorentzen, Marc P, Jennum, Poul J, Moresco, Monica, Jørgensen, Niklas R, Christensen, Gitte L, Aegidius, Helene M., Jorgensen, Niklas R., Ægidius, Helene M, Kruse, Lars, Kornum, Birgitte R.   +15 more
core   +1 more source

Hypocretins: Waking, Arousal, or Action? [PDF]

Neuron, 2005
The role of hypocretin (orexin) neurotransmission in waking and arousal, though of intense interest, is poorly understood. In this issue of Neuron, demonstrate that, in general, hypocretin neurons are minimally active during both sleep and quiet waking. In contrast, these neurons display robust activity during periods of alert and/or active waking.
Berridge, Craig W., España, Rodrigo A.
openaire   +2 more sources

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, EarlyView.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

Hypocretin and Human African Trypanosomiasis [PDF]

Sleep, 2008
To detail clinical and polysomnographic characteristics in patients affected with Trypanosoma brucei gambiense (Tb.g.) human African trypanosomiasis (HAT) at different stages of evolution and to measure and compare cerebrospinal fluid (CSF) levels of hypocretin-1 with narcoleptic patients and neurologic controls.Twenty-five untreated patients affected ...
Yves, Dauvilliers, Sylvie, Bisser, Florian, Chapotot, Gedeao, Vatunga, Raymond, Cespuglio, Téofilo, Josenando, Alain, Buguet   +6 more
openaire   +2 more sources

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation

Frontiers in Neuroscience, 2020
The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain.
Marc Fakhoury, Israa Salman, Wassim Najjar, George Merhej, Nada Lawand, Nada Lawand   +5 more
doaj   +1 more source

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats [PDF]

Neuroscience, 2007
Narcolepsy is linked to a widespread loss of neurons containing the neuropeptide hypocretin (HCRT), also named orexin. A transgenic (TG) rat model has been developed to mimic the neuronal loss found in narcoleptic humans. In these rats, HCRT neurons gradually die as a result of the expression of a poly-glutamine repeat under the control of the HCRT ...
S, Zhang, L, Lin, S, Kaur, S, Thankachan, C, Blanco-Centurion, M, Yanagisawa, E, Mignot, P J, Shiromani   +7 more
openaire   +2 more sources