Results 71 to 80 of about 13,161 (220)

Suspected acquired narcolepsy in 8 dogs

Journal of Veterinary Internal Medicine, 2021
Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy.
Koen M. Santifort, Edward J. Ives, Joe Fenn, Francesca Raimondi, Filipa Lourinho, Paul J. J. Mandigers, Niklas Bergknut   +6 more
doaj   +1 more source

Hypocretins and Arousal

, 2016
How the brain controls vigilance state transitions remains to be fully understood. The discovery of hypocretins, also known as orexins, and their link to narcolepsy has undoubtedly allowed us to advance our knowledge on key mechanisms controlling the boundaries and transitions between sleep and wakefulness.
Shi-Bin, Li, William J, Giardino, Luis, de Lecea   +2 more
openaire   +2 more sources

Orexin/Hypocretin: Wired for Wakefulness [PDF]

Current Biology, 2003
Orexin neurons play a crucial role in regulating wakefulness and energy metabolism, but until recently, little was known about the factors that influence the activity of these essential cells. Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness.
Mochizuki, Takatoshi, Scammell, Thomas E.   +1 more
openaire   +2 more sources

Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a [PDF]

, 2015
Sleep has been conserved throughout evolution; however, the molecular and neuronal mechanisms of sleep are largely unknown. The hypothalamic hypocretin/orexin (Hcrt) neurons regulate sleep/wake states, feeding, stress, and reward.
Alon, Shahar, Appelbaum, Lior, Dahary, Dvir, Diber, Alex, Elbaz, Idan, Gibbs-Bar, Liron, Lerer-Goldshtein, Tali, Yelin-Bekerman, Laura   +7 more
core   +2 more sources

The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation

Frontiers in Neuroscience, 2020
The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain.
Marc Fakhoury, Israa Salman, Wassim Najjar, George Merhej, Nada Lawand, Nada Lawand   +5 more
doaj   +1 more source

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression. [PDF]

, 2015
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta.
Benedetto, Luciana, Chase, Michael H, Lagos, Patricia, López-Hill, Ximena, Monti, Jaime M, Pascovich, Claudia, Scorza, Cecilia, Torterolo, Pablo, Urbanavicius, Jessika   +8 more
core   +3 more sources

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Hypocretins or hyporexins? [PDF]

Nature Medicine, 1998
Lettera
NISOLI E, CARRUBA MO, VALERIO, Alessandra, BORSANI, Giuseppe   +3 more
openaire   +3 more sources

iSPHYNCS: Unsupervised clustering in questionnaires and metadata reveals distinct subtypes in the narcolepsy borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Morand R, Fregolente L, van der Meer J, Wenz ES, Helmy A, Brigato L, Warncke JD, Zub K, Khatami R, Zhang Z, von Manitius S, Miano S, Acker J, Strub M, Kallweit U, Lammers GJ, Tzovara A, Bassetti CL, Mougiakakou S, Schmidt MH.   +19 more
europepmc   +2 more sources

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source