Results 81 to 90 of about 8,767 (247)
The hypocretins (orexins) mediate the “phasic” components of REM sleep: A new hypothesis
Sleep Science, 2014 In 1998, a group of phenotypically distinct neurons were discovered in the postero-lateral hypothalamus which contained the neuropeptides hypocretin 1 and hypocretin 2 (also called orexin A and orexin B), which are excitatory neuromodulators ...
Pablo Torterolo, Michael H. Chase
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Orexin/Hypocretin: Wired for Wakefulness [PDF]
Current Biology, 2003 Orexin neurons play a crucial role in regulating wakefulness and energy metabolism, but until recently, little was known about the factors that influence the activity of these essential cells. Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness.
Mochizuki, Takatoshi +1 more
openaire +2 more sources
Brain and Behavior, Volume 16, Issue 6, June 2026.In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence +14 more
wiley +1 more source
Suspected acquired narcolepsy in 8 dogs
Journal of Veterinary Internal Medicine, 2021 Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy.
Koen M. Santifort +6 more
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Headache psychiatry: A structured narrative review and integrative framework
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.Headache disorders are among the most prevalent and disabling neurological conditions worldwide, yet their psychiatric comorbidities remain systematically underrecognized in clinical practice. This narrative review introduces Psychocephalology—a biopsychosocial framework conceptualizing headache through five interacting domains: neurobiology, pain ...
Kyohei Otani
wiley +1 more source
A critical role of hypocretin deficiency in pregnancy
, 2014 Hypocretin/orexin peptides are known for their role in the control of the wake-sleep cycle and narcolepsy-cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy.
BASTIANINI, STEFANO +4 more
core +1 more source
New developments in the management of narcolepsy
Nature and Science of Sleep, 2017 Vivien C Abad, Christian Guilleminault Department of Psychiatry and Behavioral Sciences, Division of Sleep Medicine, Stanford University Outpatient Center, Redwood City, CA, USA Abstract: Narcolepsy is a life-long, underrecognized sleep disorder ...
Abad VC, Guilleminault C
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Human Vaccines & Immunotherapeutics, 2017 An increased risk of narcolepsy following administration of an AS03-adjuvanted A(H1N1)pdm09 pandemic influenza vaccine (Pandemrix™) was described in children and adolescents in certain European countries.
Camille Planty +7 more
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BMC Neuroscience, 2003 Background Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area. Both types of neurons have been implicated in the
Salin Paul +9 more
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Frontiers in Aging NeuroscienceBackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke ...
Ting Fu +7 more
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