Results 81 to 90 of about 13,161 (220)

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Nature Communications, 2019
T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and
Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins   +17 more
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individuals

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1473-1486, May 2026.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. [PDF]

PLoS ONE, 2017
Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results.
Marco Filardi, Fabio Pizza, Lorenzo Tonetti, Elena Antelmi, Vincenzo Natale, Giuseppe Plazzi   +5 more
doaj   +1 more source

Untersuchung der Dopaminrezeptor- sowie Hypocretin-Gen-Polymorphismen bei Parkinsin-Patienten mit "Schlafattacken" [PDF]

, 2004
Das idiopathische Parkinson-Syndrom (IPS) ist eine neurodegenerative Erkrankung unklarer Ätiologie. Das IPS wird klinisch durch die „Kardinalsymptome“ wie Ruhetremor, Rigor sowie Bradykinesie gekennzeichnet.
Oertel, Wolfgang Herrmann Professor, Rissling, Ida   +1 more
core   +1 more source

Narcolepsy initially misdiagnosed as schizophrenia: A case report

Sleep Research, EarlyView.
Feng Daoyi, Liu Xin, Xu Rui, He Lihua
wiley   +1 more source

Dynamic Brain State Alterations in Narcolepsy: A Hidden Markov Model Approach to Thalamocortical Instability and Symptom‐Specific Neural Correlates

Brain and Behavior, Volume 16, Issue 4, April 2026.
This graphical abstract illustrates how Hidden Markov modeling of functional magnetic resonance imaging (fMRI) reveals five dynamic brain states in narcolepsy type 1 (NT1), with reduced thalamocortical arousal (State 1) and elevated REM‐like limbic‐motor (State 4) and reward‐introspection (State 5) states linking to hallucinations and daytime ...
Wenyi Li, Lijing Jia, Xingyu Wang, Yuanhui Zhao, Zhenzhong Li, Zuojun Geng   +5 more
wiley   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Evaluation of the potential effects of AS03-adjuvanted A(H1N1)pdm09 vaccine administration on the central nervous system of non-primed and A(H1N1)pdm09-primed cotton rats

Human Vaccines & Immunotherapeutics, 2017
An increased risk of narcolepsy following administration of an AS03-adjuvanted A(H1N1)pdm09 pandemic influenza vaccine (Pandemrix™) was described in children and adolescents in certain European countries.
Camille Planty, Corey P. Mallett, Kevin Yim, Jorge C. G. Blanco, Marina Boukhvalova, Thomas March, Robbert van der Most, Eric Destexhe   +7 more
doaj   +1 more source

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

BMC Neuroscience, 2003
Background Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area. Both types of neurons have been implicated in the
Salin Paul, Boissard Romuald, Léger Lucienne, Salvert Denise, Cagnon Laurène, Fort Patrice, Goutagny Romain, Verret Laure, Peyron Christelle, Luppi Pierre-Hervé   +9 more
doaj   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, Volume 15, Issue 4, April 2026.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source