Results 101 to 110 of about 12,344 (239)
Frontiers in Pharmacology, 2015 Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake states can be an early condition that exacerbates these disorders. Therefore, treating sleep-wake dysfunction may prevent or slow the development of these diseases.
Yuhei eNishimura +16 more
doaj +1 more source
Salivary biomarkers in sleep‐related disorders
Sleep Research, Volume 3, Issue 3, Page 272-285, September 2026.Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li +9 more
wiley +1 more source
Hypocretin and melanin-concentrating hormone in patients with Huntington disease. [PDF]
, 2008 To evaluate whether hypocretin-1 (orexin-A) and melanin-concentrating hormone (MCH) neurotransmission are affected in patients with Huntington disease (HD), we immunohistochemically stained hypocretin and MCH neurons and estimated their total numbers in ...
Swaab, D.F. +13 more
core +1 more source
Hypocretin Mediates Sleep and Wake Disturbances in a Mouse Model of Traumatic Brain Injury
Journal of Neurotrauma, 2019 Traumatic brain injury (TBI) is a major cause of disability worldwide. Post-TBI sleep and wake disturbances are extremely common and difficult for patients to manage.
H. Thomasy, M. Opp
semanticscholar +1 more source
The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease
Brain Pathology, Volume 36, Issue 5, September 2026.SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery +17 more
wiley +1 more source
Hypocretin/Orexin Neurons Endogenously Regulate Somatic Motoneuron Excitability
, 2011 The role of hypocretin neurons in modulating somatic motoneuron excitability and hence muscle tone is poorly understood. We investigated whether hypocretin neurons influence the hypoglossal and trigeminal motor pools that innervate the genioglossus and ...
Saleh, Asem
core +2 more sources
Hypocretin underlies the evolution of sleep loss in the Mexican cavefish
bioRxiv, 2017 The duration of sleep varies dramatically between species, yet little is known about genetic bases or evolutionary factors driving this variation in behavior.
James B. Jaggard +5 more
semanticscholar +1 more source
A critical role of hypocretin deficiency in pregnancy
, 2014 Hypocretin/orexin peptides are known for their role in the control of the wake-sleep cycle and narcolepsy-cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy.
BASTIANINI, STEFANO +4 more
core +1 more source
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
doaj +1 more source
Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”
Frontiers in Pharmacology, 2018 In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated ...
Idris A. Azeez +4 more
doaj +1 more source