Results 101 to 110 of about 13,161 (220)

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae, Jessica Marie Hunter Alberhasky, Marion Baillet, Debra A. Bangasser, Michael E. Belloy, Anne S. Berry, Chiara Berteotti, Hannah Bow, Rachel Buckley, Jessica Z. K. Caldwell, Matteo Carpi, Benjamin J. Clark, Claire J. Ciampa, Alexander C. Conley, Martin J. Dahl, Zoe R. Donaldson, Alexander J. Ehrenberg, Gillian Einstein, Neus Falgàs, Haley A. Fenlon, Megan C. Fitzhugh, Robert C. Froemke, Clara Gallay, Lea Tenenholz Grinberg, Derek A. Hamilton, Zia Hasan, Oihane Uriarte Huarte, Shaista Jabeen, Heidi I. L. Jacobs, Louis John Kolling, Elouise A. Koops, Sabrina Lenzoni, Claudio Liguori, Riccardo Manca, Catherine A. Marcinkiewcz, Tamunotonye Omoluabi, Rademene Oria, Caitlin A. Orsini, Nancy Elizabeth Ortega, Judy Pa, Nathan S. Pentkowski, Joana B. Pereira, Rhudovic Ramos, Derya Sargin, Abhijit Satpati, Maria Clara Selles, Mabel Seto, Shabana M. Shaik, Shireen Sindi, Gowoon Son, Valentine Ucheagwu, Maxime Van Egroo, Qi Yuan, Michael A. Kelberman   +53 more
wiley   +1 more source

Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling [PDF]

, 2017
In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived peptide α–melanocytestimulating hormone (α-MSH) promote satiety. POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A receptor type
Buono, Lorena, Cristino, Luigia, Morello, Giovanna   +2 more
core   +1 more source

Wake‐promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Taylor J. Pedersen, Sabrina G. Clemens, Joseph R. Winer, Ashish Sharma, Neus Falgàs, Brendan P. Lucey, Brian A. Gordon, Erik S. Musiek   +7 more
wiley   +1 more source

Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”

Frontiers in Pharmacology, 2018
In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated ...
Idris A. Azeez, Federico Del Gallo, Luigia Cristino, Marina Bentivoglio, Marina Bentivoglio   +4 more
doaj   +1 more source

Orexin/Hypocretin Signaling

, 2016
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other ...
openaire   +2 more sources

Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports

Frontiers in Neurology, 2019
Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both ...
Zhen-Ni Guo, Xin Sun, Yingkai Zhao, Xiuli Yan, Ran Zhang, Zan Wang, Yi Yang, Yi Yang   +7 more
doaj   +1 more source

A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac [PDF]

, 2013
The aim of this study is the evaluation of electron dose enhancement and photon contamination production by various nanoparticles in the electron mode of a medical linac. MCNPX Monte Carlo code was used for simulation of Siemens Primus linac as well as a
Toossi, Mohammad Taghi Bahreyni, Ghorbani, Mahdi, Sabet, Leila Sobhkhiz, Akbari, Fateme, Mehrpouyan, Mohammad   +4 more
core   +3 more sources

Relato de dois casos de pacientes com narcolepsia com melhora dos sintomas após uso de prednisona [PDF]

, 2007
This article focuses on 2 clinical case reports of narcoleptic patients who experienced an absence of excessive sleepiness during treatment of other illnesses with 40 mg daily intake of prednisone.Este artigo refere-se à discussão de 2 casos de pacientes
Alves, Gabriela Rodrigues, Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +2 more sources

Hypocretin as a Hub for Arousal and Motivation

Frontiers in Neurology, 2018
The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior.
Susan M. Tyree, Jeremy C. Borniger, Luis de Lecea   +2 more
doaj   +1 more source

Regulation of zebrafish sleep and arousal states: current and prospective approaches

Frontiers in Neural Circuits, 2013
Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and ...
Cindy N Chiu, David A Prober
doaj   +1 more source