Results 101 to 110 of about 8,767 (247)
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
doaj +1 more source
Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior
Brain Research, 2018 At its discovery, orexin/hypocretin (OX) was hypothesized to promote food intake. Subsequently, with the identification of the participation of OX in numerous other phenomena, including arousal and drug seeking, this neuropeptide was proposed to be ...
Jessica R. Barson
semanticscholar +1 more source
Addiction and arousal: the hypocretin connection
, 2008 The hypocretins, also known as orexins, are two neuropeptides now commonly described as critical components to maintain and regulate the stability of arousal. Several lines of evidence have raised the hypothesis that hypocretin-producing neurons are part
Boutrel, B., de Lecea, L.
core +1 more source
, 2023 Recent studies have focused on how sickness behaviours, including lethargy, are coordinated in the brain in response to peripheral infections. Decreased hypocretin (orexin) signalling is associated with lethargy and previous research suggests that ...
Kornum, Birgitte Rahbek +3 more
core +1 more source
Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”
Frontiers in Pharmacology, 2018 In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated ...
Idris A. Azeez +4 more
doaj +1 more source
, 2016 Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other ...
openaire +2 more sources
Hypocretin neurotransmitter system and narcolepsy
Vojnosanitetski pregled, 2008 <zakljucak> Prelomno otkrice nedostatka hipokretina kod narkolepsije pruza izvrsnu osnovu za bolje razumevanje fiziologije spavanja i podsticaj je za buduca istrazivanja. Medjutim, ono nije omogucilo da se razresi enigma etiologije narkolepsije.
Lakočević Milan B., Rajšić Nenad R.
openaire +3 more sources
Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports
Frontiers in Neurology, 2019 Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both ...
Zhen-Ni Guo +7 more
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Narcolepsy initially misdiagnosed as schizophrenia: A case report
Sleep Research, Volume 3, Issue 2, Page 180-184, June 2026.
Feng Daoyi, Liu Xin, Xu Rui, He Lihua
wiley +1 more source
Orexin/hypocretin system: Role in food and drug overconsumption
International review of neurobiology, 2017 The neuropeptide orexin/hypocretin (OX), while largely transcribed within the hypothalamus, is released throughout the brain to affect complex behaviors.
Jessica R. Barson, S. Leibowitz
semanticscholar +1 more source