Results 121 to 130 of about 8,767 (247)

CSF HYPOCRETIN CONCENTRATION IN VARIOUS NEUROLOGICAL AND SLEEP DISORDERS

Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease.
Sato, Masahiro, Shimizu, Tetsuo, Tokunaga, Jun, Tsutsui, Kou, Kanbayashi, Takashi, Sawaishi, Yukio   +5 more
core   +1 more source

Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far

Frontiers in Neuroscience, 2013
Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well ...
África eFlores, Rafael eMaldonado, Fernando eBerrendero   +2 more
doaj   +1 more source

Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy

, 2013
Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans.
Savvidou, Andri, Knudsen, Stine, Jennum, Poul, Palm, Lars,, Gammeltoft, Steen, Olsson-Engman, Mia, Lund University., Palm, Lars   +7 more
core   +1 more source

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy.

, 2015
The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most important advance in sleep research and sleep medicine since the discovery of rapid eye movement sleep.
Tafti, M., Liblau, R.S., Seifinejad, A., Vassalli, A.   +3 more
core   +1 more source

Olfactory Dysfunction and Hypocretin in Narcolepsy

, 2008
CSF orexin A (hypocretin-1) is decreased or absent in narcoleptic patients with ...
J Gordon Millichap
core   +1 more source

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

Cell, 1999
Ling Lin, J. Faraco, Robin Li, H. Kadotani, W. Rogers, Xiaoyan Lin, Xiaohong Qiu, P. Jong, S. Nishino, E. Mignot   +9 more
semanticscholar   +1 more source

Hypocretin deficiency. Neuronal loss and functional consequences.

, 2008
The first part deals with the hypothalamic hypocretin system in disorders that are accompanied by narcolepsy-like sleep disturbances, i.e. Prader-Willi Syndrome, Parkinson__s Disease and Huntington__s Disease.
Fronczek, R.
core  

HLA DQB1*06:02 Negative Narcolepsy with Hypocretin/Orexin Deficiency

, 2014
Study Objectives: To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02. Settings: China (Peking University People's Hospital), Czech Republic (Charles University)
Juliane Winkelmann, Sona Nevsimalova, Pizza, Fabio, Han, Fang, J. Winkelmann, M. Mindrinos, S. Nevsimalova, F. Han, Hanna M. Ollila, T. M. Strom, Michael Mindrinos, C. Coquillard, T. M. Strom, Winkelmann, Juliane, Pizza, F., Vina, M.F., Fang Han, Plazzi, G., F. Babrzadeh, S. Nevsimalova, P. Jennum, Fernandez Vina, Marcelo, Tim M. Strom, Nevsimalova, S., Jennum, P., Vina, Marcelo Fernandez, Jennum, Poul, P. Jennum, Fabio Pizza, Barbara Schormair, Stine Knudsen, M. F. Vina, Lin, Ling, Mindrinos, M., C. Coquillard, E. Mignot, Strom, T.M., G. Plazzi, Farbod Babrzadeh, Marcelo Fernandez Vina, E. Mignot, Schormair, B., H. M. Ollila, Ollila, Hanna M., Mignot, Emmanuel, Emmanuel Mignot, S. Knudsen, Knudsen, Stine, F. Babrzadeh, Ollila, H.M., Knudsen, S., B. Schormair, Mindrinos, Michael, Coquillard, Cristin, Ling Lin, Babrzadeh, F., Wang, Chunlin, Strom, Tim M., Wang, C., Mignot, E., Winkelmann, J., Coquillard, C., Strom, Tim M, Chunlin Wang, L. Lin, B. Schormair, F. Pizza, Plazzi, Giuseppe, Schormair, Barbara, Giuseppe Plazzi, S. Knudsen, Cristin Coquillard, Lin, L., Babrzadeh, Farbod, Nevsimalova, Sona, C. Wang, F. Han, H. M. Ollila, Han, F., M. F. Vina, Ollila, Hanna M, C. Wang, Poul Jennum, L. Lin, M. Mindrinos, J. Winkelmann   +85 more
core   +1 more source

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

CSF hypocretin-1 levels are normal in multiple-system atrophy.

, 2008
Contains fulltext : 70147.pdf (Publisher’s version ) (Open Access)Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a
Lammers, G.J., Bloem, B.R., Kremer, H.P.H., Abdo, W.F., Verbeek, M.M., Overeem, S.   +5 more
core   +1 more source