Results 121 to 130 of about 12,344 (239)

Hypocretin deficiency. Neuronal loss and functional consequences. [PDF]

, 2008
The first part deals with the hypothalamic hypocretin system in disorders that are accompanied by narcolepsy-like sleep disturbances, i.e. Prader-Willi Syndrome, Parkinson__s Disease and Huntington__s Disease.
Fronczek, R.
core  

Orexin/hypocretin system: Role in food and drug overconsumption

International review of neurobiology, 2017
The neuropeptide orexin/hypocretin (OX), while largely transcribed within the hypothalamus, is released throughout the brain to affect complex behaviors.
Jessica R. Barson, S. Leibowitz
semanticscholar   +1 more source

Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far

Frontiers in Neuroscience, 2013
Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well ...
África eFlores, Rafael eMaldonado, Fernando eBerrendero   +2 more
doaj   +1 more source

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury

, 2005
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally
Mignot, E, Trentz, O, Hersberger, M; https://orcid.org/, Stocker, R, Imhof, H G, Bassetti, C L, Baumann, C R   +6 more
core   +1 more source

Cerebrospinal fluid hypocretin-1 levels during the active period of cluster headache

, 2011
BACKGROUND: Hypocretins (orexins) are hypothalamic neuropeptides which are involved in a wide range of physiological processes in mammals including central pain processing.
Claudio L Bassetti, Pizza, Fabio, Nicodemo, Marianna, Grimaldi D., Cevoli S., Daniela Grimaldi, Valko, Philipp O, Cevoli, S, Nicodemo, M, Pierangeli, Giulia, Giulia Pierangeli, Pierangeli, G, Christian R Baumann, Pasquale Montagna, Nicodemo M., Favoni, Valentina, Valko P. O., Montagna, P, Montagna, Pasquale, Grimaldi, D, Cortelli, P, Sabina Cevoli, Favoni, V, Valentina Favoni, Baumann C. R., Fabio Pizza, Bassetti C. L., Bassetti, C L, Cevoli, Sabina, Cortelli, Pietro, Grimaldi, Daniela, Baumann, C R, Marianna Nicodemo, Montagna P., Bassetti, Claudio L, Philipp O Valko, Pizza, F, Baumann, Christian R, Pietro Cortelli, Valko, P O   +39 more
core   +1 more source

Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord

, 1999
Hypocretin (orexin) is synthesized by neurons in the lateral hypothalamus and has been reported to increase food intake and regulate the neuroendocrine system.
Anthony N. van den Pol
core   +1 more source

G protein activation and acetylcholine release stimulated by hypocretin in the rat pons.

, 2005
Multiple brain stem nuclei, including locus coeruleus (LC), dorsal raphe nucleus (DR), and the oral (PnO) and caudal (PnC) part of the pontine reticular formation participate in the modulation of arousal states.
Bernard, Rene
core   +3 more sources

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy.

, 2015
The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most important advance in sleep research and sleep medicine since the discovery of rapid eye movement sleep.
Tafti, M., Liblau, R.S., Seifinejad, A., Vassalli, A.   +3 more
core   +1 more source

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

Cell, 1999
Ling Lin, J. Faraco, Robin Li, H. Kadotani, William Rogers, Xiaoyan Lin, Xiaohong Qiu, P. D. de Jong, S. Nishino, E. Mignot   +9 more
semanticscholar   +1 more source

An optimized method for measuring hypocretin-1 peptide in the mouse brain reveals differential circadian regulation of hypocretin-1 levels rostral and caudal to the hypothalamus

, 2015
The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity.
Kornum, B R, Justinussen, J L, Holm, A
core   +1 more source