Results 111 to 120 of about 8,767 (247)

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury

, 2005
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally
Mignot, E, Trentz, O, Hersberger, M; https://orcid.org/, Stocker, R, Imhof, H G, Bassetti, C L, Baumann, C R   +6 more
core   +1 more source

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

OncoTarget, 2018
Pancreatic ductal adenocarcinoma (PDAC) is still the poorest prognostic tumor of the digestive system. We investigated the antitumoral role of orexin-A and almorexant in PDAC.
S. Dayot, Daniela Speisky, A. Couvelard, P. Bourgoin, V. Gratio, J. Cros, V. Rebours, A. Sauvanet, P. Bedossa, V. Paradis, P. Ruszniewski, A. Couvineau, T. Voisin   +12 more
semanticscholar   +1 more source

Hypocretin and melanin-concentrating hormone in patients with Huntington disease.

, 2008
To evaluate whether hypocretin-1 (orexin-A) and melanin-concentrating hormone (MCH) neurotransmission are affected in patients with Huntington disease (HD), we immunohistochemically stained hypocretin and MCH neurons and estimated their total numbers in ...
Swaab, D.F., Roelandse, F.W., Van Duinen, S., Duinen, S.G. van, Fronczek, R., Maat-Schieman, M.L., Unmehopa, U.A., Roelandse, F., Aziz, A., Lammers, G.J., Roos, R., Roos, R.A.C., Overeem, S., Maat-Schieman, M.   +13 more
core   +1 more source

Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.

Current topics in behavioral neurosciences, 2017
Orexins (hypocretins) are critically involved in coordinating appropriate physiological and behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin neurons via direct projections from stress-sensitive brain regions. Orexin
M. James, E. Campbell, C. Dayas
semanticscholar   +1 more source

An optimized method for measuring hypocretin-1 peptide in the mouse brain reveals differential circadian regulation of hypocretin-1 levels rostral and caudal to the hypothalamus

, 2015
The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity.
Kornum, B R, Justinussen, J L, Holm, A
core   +1 more source

Regulation of zebrafish sleep and arousal states: current and prospective approaches

Frontiers in Neural Circuits, 2013
Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and ...
Cindy N Chiu, David A Prober
doaj   +1 more source

Temporal Changes in the Cerebrospinal Fluid Level of Hypocretin-1 and Histamine in Narcolepsy

Sleep, 2017
Study Objectives: To follow the temporal changes of cerebrospinal fluid (CSF) biomarker levels in narcoleptic patients with unexpected hypocretin level at referral.
R. Lopez, L. Barateau, Elisa Evangelista, S. Chenini, P. Robert, I. Jaussent, Y. Dauvilliers   +6 more
semanticscholar   +1 more source

Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord

, 1999
Hypocretin (orexin) is synthesized by neurons in the lateral hypothalamus and has been reported to increase food intake and regulate the neuroendocrine system.
Anthony N. van den Pol
core   +1 more source

Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury

Neurobiology of Sleep and Circadian Rhythms, 2017
Disorders of sleep and wakefulness occur in the majority of individuals who have experienced traumatic brain injury (TBI), with increased sleep need and excessive daytime sleepiness often reported.
Hannah E. Thomasy, Heidi Y. Febinger, Kristyn M. Ringgold, Carmelina Gemma, Mark R. Opp   +4 more
doaj   +1 more source

Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".

, 2015
Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et ...
Li, S., Tafti, M., Vassalli, A.
core   +1 more source