Results 111 to 120 of about 12,344 (239)
Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription
International Journal of Molecular Medicine, 2019 The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene-like 1 (Plagl1), which encodes a C2H2 zinc-finger ...
Susumu Tanaka +11 more
semanticscholar +1 more source
Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports
Frontiers in Neurology, 2019 Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both ...
Zhen-Ni Guo +7 more
doaj +1 more source
Effects of Traumatic Brain Injury on the Orexin/Hypocretin System
Neurotrauma ReportsTraumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach +2 more
doaj +1 more source
Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior
Brain Research, 2018 At its discovery, orexin/hypocretin (OX) was hypothesized to promote food intake. Subsequently, with the identification of the participation of OX in numerous other phenomena, including arousal and drug seeking, this neuropeptide was proposed to be ...
Jessica R. Barson
semanticscholar +1 more source
, 2016 Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other ...
openaire +2 more sources
Addiction and arousal: the hypocretin connection
, 2008 The hypocretins, also known as orexins, are two neuropeptides now commonly described as critical components to maintain and regulate the stability of arousal. Several lines of evidence have raised the hypothesis that hypocretin-producing neurons are part
Boutrel, B., de Lecea, L.
core +1 more source
Regulation of zebrafish sleep and arousal states: current and prospective approaches
Frontiers in Neural Circuits, 2013 Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and ...
Cindy N Chiu, David A Prober
doaj +1 more source
A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?
Current topics in behavioral neurosciences, 2016 One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin signaling with drug seeking by showing that activation of these neurons promotes conditioned morphine-seeking behavior.
M. James +3 more
semanticscholar +1 more source
OncoTarget, 2018 Pancreatic ductal adenocarcinoma (PDAC) is still the poorest prognostic tumor of the digestive system. We investigated the antitumoral role of orexin-A and almorexant in PDAC.
S. Dayot +12 more
semanticscholar +1 more source
Neurobiology of Sleep and Circadian Rhythms, 2017 Disorders of sleep and wakefulness occur in the majority of individuals who have experienced traumatic brain injury (TBI), with increased sleep need and excessive daytime sleepiness often reported.
Hannah E. Thomasy +4 more
doaj +1 more source