Results 91 to 100 of about 8,767 (247)

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

Hypocretin Mediates Sleep and Wake Disturbances in a Mouse Model of Traumatic Brain Injury

Journal of Neurotrauma, 2019
Traumatic brain injury (TBI) is a major cause of disability worldwide. Post-TBI sleep and wake disturbances are extremely common and difficult for patients to manage.
H. Thomasy, M. Opp
semanticscholar   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Ken-ichi Yagami, Bernard Bettler, Thomas Kilduff, Satoshi Kunita, Hitomi Takahira, Taizo Matsuki, Mika Nomiyama, Takeshi Sakurai, Noriko Hirashima, Satoru Takahashi, Masashi Yanagisawa   +10 more
core  

Hypocretin underlies the evolution of sleep loss in the Mexican cavefish

bioRxiv, 2017
The duration of sleep varies dramatically between species, yet little is known about genetic bases or evolutionary factors driving this variation in behavior.
James B. Jaggard, B. A. Stahl, Evan Lloyd, D. Prober, Erik R. Duboué, A. Keene   +5 more
semanticscholar   +1 more source

Hypocretin/Orexin Neurons Endogenously Regulate Somatic Motoneuron Excitability

, 2011
The role of hypocretin neurons in modulating somatic motoneuron excitability and hence muscle tone is poorly understood. We investigated whether hypocretin neurons influence the hypoglossal and trigeminal motor pools that innervate the genioglossus and ...
Saleh, Asem
core   +1 more source

Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge

Frontiers in Neuroscience, 2015
Exposure to early life physiological stressors, such as infection, is thought to contribute to the onset of psychopathology in adulthood. In animal models, injections of the bacterial immune challenge, lipopolysaccharide (LPS), during the neonatal period
Erin Jane Campbell, Stephanie M Watters, Ihssane eZouikr, Deborah M Hodgson, Christopher V Dayas   +4 more
doaj   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers

Frontiers in Pharmacology, 2015
Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake states can be an early condition that exacerbates these disorders. Therefore, treating sleep-wake dysfunction may prevent or slow the development of these diseases.
Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Shiko eOkabe, Shota eSasagawa, Soichiro eMurakami, Yoshifumi eAshikawa, Mizuki eYuge, Koki eKawaguchi, Reiko eKawase, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka   +16 more
doaj   +1 more source

Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription

International Journal of Molecular Medicine, 2019
The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene-like 1 (Plagl1), which encodes a C2H2 zinc-finger ...
Susumu Tanaka, Yoshiko Honda, Shizuka Takaku, T. Koike, Souichi Oe, Y. Hirahara, T. Yoshida, N. Takizawa, Y. Takamori, Kiyoshi Kurokawa, Tohru Kodama, Hisao Yamada   +11 more
semanticscholar   +1 more source

Cerebrospinal fluid hypocretin-1 levels during the active period of cluster headache

, 2011
BACKGROUND: Hypocretins (orexins) are hypothalamic neuropeptides which are involved in a wide range of physiological processes in mammals including central pain processing.
Claudio L Bassetti, Pizza, Fabio, Nicodemo, Marianna, Grimaldi D., Cevoli S., Daniela Grimaldi, Valko, Philipp O, Cevoli, S, Nicodemo, M, Pierangeli, Giulia, Giulia Pierangeli, Pierangeli, G, Christian R Baumann, Pasquale Montagna, Nicodemo M., Favoni, Valentina, Valko P. O., Montagna, P, Montagna, Pasquale, Grimaldi, D, Cortelli, P, Sabina Cevoli, Favoni, V, Valentina Favoni, Baumann C. R., Fabio Pizza, Bassetti C. L., Bassetti, C L, Cevoli, Sabina, Cortelli, Pietro, Grimaldi, Daniela, Baumann, C R, Marianna Nicodemo, Montagna P., Bassetti, Claudio L, Philipp O Valko, Pizza, F, Baumann, Christian R, Pietro Cortelli, Valko, P O   +39 more
core   +1 more source