Results 91 to 100 of about 12,344 (239)
Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. [PDF]
PLoS ONE, 2017 Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results.
Marco Filardi +5 more
doaj +1 more source
Orexin/Hypocretin: Wired for Wakefulness [PDF]
Current Biology, 2003 Orexin neurons play a crucial role in regulating wakefulness and energy metabolism, but until recently, little was known about the factors that influence the activity of these essential cells. Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness.
Mochizuki, Takatoshi +1 more
openaire +2 more sources
MedComm, Volume 7, Issue 10, October 2026.This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng +4 more
wiley +1 more source
BMC Neuroscience, 2003 Background Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area. Both types of neurons have been implicated in the
Salin Paul +9 more
doaj +1 more source
Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators
American Journal of Human Biology, Volume 38, Issue 9, September 2026.Overview of the study design and main findings on the associations among sun exposure, sleep duration, and obesity indicators in Portuguese children. ABSTRACT Introduction Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health.
Elizabete A. dos Santos +5 more
wiley +1 more source
The hypocretin/orexin system mediates the extinction of fear memories
, 2014 Anxiety disorders are often associated with an inability to extinguish learned fear responses. The hypocretin/orexin system is involved in the regulation of emotional states and could also participate in the consolidation and extinction of aversive ...
COSTA, GIULIA +5 more
core +2 more sources
Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications
Neuroprotection, Volume 4, Issue 3, Page 229-247, September 2026.Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh +2 more
wiley +1 more source
Frontiers in Neuroscience, 2015 Exposure to early life physiological stressors, such as infection, is thought to contribute to the onset of psychopathology in adulthood. In animal models, injections of the bacterial immune challenge, lipopolysaccharide (LPS), during the neonatal period
Erin Jane Campbell +4 more
doaj +1 more source
Assessing mortality risk in narcolepsy: Evidence from population studies
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.Abstract Narcolepsy is a chronic neurologic sleep disorder associated with excessive daytime sleepiness, cataplexy, and a higher prevalence of cardiovascular and psychiatric comorbidities. While these factors may predispose individuals to adverse events, observational studies evaluating mortality in narcolepsy have yielded inconsistent results.
Nawris Alhassan +2 more
wiley +1 more source
Frontiers in Aging NeuroscienceBackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke ...
Ting Fu +7 more
doaj +1 more source