Results 91 to 100 of about 13,161 (220)

New developments in the management of narcolepsy

Nature and Science of Sleep, 2017
Vivien C Abad, Christian Guilleminault Department of Psychiatry and Behavioral Sciences, Division of Sleep Medicine, Stanford University Outpatient Center, Redwood City, CA, USA Abstract: Narcolepsy is a life-long, underrecognized sleep disorder ...
Abad VC, Guilleminault C
doaj  

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers   +4 more
wiley   +1 more source

Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge

Frontiers in Neuroscience, 2015
Exposure to early life physiological stressors, such as infection, is thought to contribute to the onset of psychopathology in adulthood. In animal models, injections of the bacterial immune challenge, lipopolysaccharide (LPS), during the neonatal period
Erin Jane Campbell, Stephanie M Watters, Ihssane eZouikr, Deborah M Hodgson, Christopher V Dayas   +4 more
doaj   +1 more source

Facial Emotion Recognition in Children With Narcolepsy Type 1

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Narcolepsy type 1 is a neurological disorder typically emerging in childhood or adolescence, characterised by excessive daytime sleepiness, cataplexy and rapid eye movement sleep‐related symptoms. Beyond its core features, increasing evidence suggests an impact on socio‐cognitive development, including difficulties in understanding others ...
Marco Veneruso, Paola Del Sette, Ramona Cordani, Antonella Barbieri, Lorenzo Chiarella, Serena Lecce, Cristina Venturino, Salvatore Lo Cascio, Francesco Biscarini, Fabio Pizza, Lino Nobili, Giuseppe Plazzi   +11 more
wiley   +1 more source

Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers

Frontiers in Pharmacology, 2015
Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake states can be an early condition that exacerbates these disorders. Therefore, treating sleep-wake dysfunction may prevent or slow the development of these diseases.
Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Yuhei eNishimura, Shiko eOkabe, Shota eSasagawa, Soichiro eMurakami, Yoshifumi eAshikawa, Mizuki eYuge, Koki eKawaguchi, Reiko eKawase, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka, Toshio eTanaka   +16 more
doaj   +1 more source

Hypocretin neurotransmitter system and narcolepsy

Vojnosanitetski pregled, 2008
<zakljucak> Prelomno otkrice nedostatka hipokretina kod narkolepsije pruza izvrsnu osnovu za bolje razumevanje fiziologije spavanja i podsticaj je za buduca istrazivanja. Medjutim, ono nije omogucilo da se razresi enigma etiologije narkolepsije.
Lakočević Milan B., Rajšić Nenad R.
openaire   +3 more sources

Physiological significance of autocrine orexinergic signaling in extra‐hypothalamic tissues

Physiological Reports, Volume 14, Issue 8, April 2026.
Mechanisms of autocrine orexinergic effects in extra‐hypothalamic tissues. Abstract Orexin‐A and orexin‐B, originally discovered as hypothalamic neuropeptides, have been detected in extra‐hypothalamic tissues together with their receptors (OX1R and OX2R) since the early 2000s.
Jean Claude Hakizimana, Makinde Vincent Olubiyi, Abdullateef Isiaka Alagbonsi   +2 more
wiley   +1 more source

The expanding toolkit of translating ribosome affinity purification [PDF]

, 2017
Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has been applied both to identify target molecules in cell types that are important for controlling a
Dougherty, Joseph D
core   +2 more sources

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]

, 2014
Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F., Lüthi, A., Massonnet, C., Perin, M., Welker, E.   +4 more
core   +1 more source