Results 41 to 50 of about 12,344 (239)
The Orexins/Hypocretins and Schizophrenia [PDF]
Schizophrenia Bulletin, 2006 Advances in molecular biology have led to new peptides and proteins being discovered on a regular basis, including the isolation of a number of neurotransmitter candidates. Rarely, however, do these immediately capture the attention of the scientific community.
Ariel Y, Deutch, Michael, Bubser
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Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors.
Neuropharmacology, 2020 The neuropeptide hypocretin/orexin plays a broad and important role in physiological functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and homeostatic regulation.
F. Hopf
semanticscholar +1 more source
Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
Frontiers in Behavioral Neuroscience, 2013 ajor advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy caused by the early loss of hypothalamic hypocretin neurons.
Sophie eBayard, Yves A Dauvilliers
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Cellular Signaling Mechanisms of Hypocretin/Orexin.
Monographs in neural sciences, 2021 Orexin receptors (OXRs) are promiscuous G-protein-coupled receptors that signal via several G-proteins and, putatively, via other proteins. On which basis the signal pathways are selected and orchestrated is largely unknown.
J. Kukkonen, Pauli M Turunen
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Frontiers in Systems Neuroscience, 2015 The neuronal system that resides in the perifornical and lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide hypocretin/orexin participates in critical brain functions across species from fish to human.
Xiao-Bing eGao, Gretchen eHermes
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, 2016 How the brain controls vigilance state transitions remains to be fully understood. The discovery of hypocretins, also known as orexins, and their link to narcolepsy has undoubtedly allowed us to advance our knowledge on key mechanisms controlling the boundaries and transitions between sleep and wakefulness.
Shi-Bin, Li +2 more
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Neurotrauma Reports, 2023 Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and ...
Manoj Govindarajulu +4 more
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Hypocretin/orexin deficiency decreases cocaine abuse liability
Neuropharmacology, 2018 Compelling evidence indicates that hypocretin/orexin signaling regulates arousal, stress and reward-seeking behaviors. However, most studies on drug reward-related processes have so far described the effects of pharmacological blockers disrupting ...
N. Steiner +7 more
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Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste? [PDF]
Sleep ScienceAuthors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy.
Giselle de Martin Truzzi +2 more
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Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance This work shows that the amidated terminal ends of the secreted hypocretin (HCRT) peptides (HCRTNH2) are autoantigens in type 1 narcolepsy, an autoimmune disorder targeting HCRT neurons.
G. Luo +7 more
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