Results 41 to 50 of about 13,161 (220)

Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals

Frontiers in Systems Neuroscience, 2015
The neuronal system that resides in the perifornical and lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide hypocretin/orexin participates in critical brain functions across species from fish to human.
Xiao-Bing eGao, Gretchen eHermes
doaj   +1 more source

Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypothalamus and Pineal Gland in Rats: An Exploratory Study

Neurotrauma Reports, 2023
Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and ...
Manoj Govindarajulu, Mital Y. Patel, Jishnu Krishnan, Joseph B. Long, Peethambaran Arun   +4 more
doaj   +1 more source

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model [PDF]

, 2014
Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of arewarding ...
Patrone, Anabela, Perello, Mario, Reynaldo, Mirta Beatriz, Valdivia Torres, Lesly Spring   +3 more
core   +2 more sources

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]

, 2017
BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette, Connor, Kathryn M, Herring, W Joseph, Hutzelmann, Jill, Krystal, Andrew D, Lines, Christopher, Michelson, David, Snavely, Duane, Thase, Michael, Trivedi, Madhukar H   +9 more
core   +1 more source

Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste? [PDF]

Sleep Science
Authors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy.
Giselle de Martin Truzzi, Renata Carvalho Cremaschi, Fernando Morgadinho Coelho   +2 more
doaj   +1 more source

Sleep Disorders and Genes [PDF]

, 2019
Versão preprintThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle.
Amici, Amin, Ban, Barbagallo, Basheer, Borbely, Brando, Brower, Byrne, Cade, Cade, Carskadon, Chaki, Chang, Chase, Chatterjee, Chen, Cohen, Cohen, Dall’Ara, de Lima, Dement, Dijk, Dong, Evans, Franco-Tormo, Fuh, Gan-Or, Gillombardo, Gottesmann, Gottesmann, Guilleminault, Han, Hennessy, Hirotsu, Hobson, Hobson, Hu, Huang, Huang, Jinek, Johansson, Keenan, Khan, Li, Lin, Lind, Luo, Lusk, Mahowald, Mendlewicz, Mistlberger, Miyagawa, Monti, Murillo-Rodríguez, Naiman, Nir, Nishino, Nordgren, Ollila, Pace-Schott, Palagini, Panda, Pandi-Perumal, Parish, Parmeggiani, Parsons, Patel, Peirano, Petit, Posner, Potter, Rechtschaffen, Riddle, Rizzo, Roffwarg, Scammell, Scherer, Serretti, Serretti, Shalem, Siclari, Siegel, Spada, Subramani, Szentkirályi, Tafti, Torterolo, Torterolo, Torterolo, Torterolo, Torterolo, Toth, Toyoda, Truong, Turek, Utge, van Maanen, Videnovic, Von Economo, Wu, Yong   +101 more
core   +1 more source

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study. [PDF]

PLoS ONE, 2015
The proper functioning of the mesolimbic reward system is largely dependent on the neurotransmitter dopamine. Recent evidence suggests that the hypocretin system has significant projections to this reward system.
Armand Mensen, Rositsa Poryazova, Gordana Huegli, Christian R Baumann, Sophie Schwartz, Ramin Khatami   +5 more
doaj   +1 more source

Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes [PDF]

, 2016
Background: The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion of the neuropil has ...
Bentivoglio, Marina, Bradley, Barbara, Etet, Paul F. Seke, Grassi-Zucconi, Gigliola, Kennedy, Peter G.E., Laperchia, Claudia, Montague, Paul, Palomba, Maria, Rodgers, Jean   +8 more
core   +4 more sources

The hypocretins and sleep [PDF]

The FEBS Journal, 2005
The hypocretins (also called the orexins) are two neuropeptides derived from the same precursor whose expression is restricted to a few thousand neurons of the lateral hypothalamus. Two G‐protein coupled receptors for the hypocretins have been identified, and these show different distributions within the central nervous system and differential ...
Luis, de Lecea, J Gregor, Sutcliffe
openaire   +2 more sources

Narcolepsy and emotional experience: a review of the literature [PDF]

, 2018
Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. This disease affects significantly the overall patient functioning, interfering with social, work, and ...
De Gennaro, Luigi, D’Atri, A., Gorgoni, M., Scarpelli, S., Schiappa, C.   +4 more
core   +1 more source