Results 41 to 50 of about 8,767 (247)

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Nature Communications, 2019
Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease ...
N. W. Pedersen, A. Holm, N. Kristensen, Anne-Mette Bjerregaard, A. Bentzen, A. Marquard, Tripti Tamhane, K. Burgdorf, H. Ullum, P. Jennum, S. Knudsen, S. Hadrup, B. Kornum   +12 more
semanticscholar   +1 more source

Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypothalamus and Pineal Gland in Rats: An Exploratory Study

Neurotrauma Reports, 2023
Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and ...
Manoj Govindarajulu, Mital Y. Patel, Jishnu Krishnan, Joseph B. Long, Peethambaran Arun   +4 more
doaj   +1 more source

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This work shows that the amidated terminal ends of the secreted hypocretin (HCRT) peptides (HCRTNH2) are autoantigens in type 1 narcolepsy, an autoimmune disorder targeting HCRT neurons.
Guo Luo, A. Ambati, Ling Lin, M. Bonvalet, M. Partinen, X. Ji, H. Maecker, E. Mignot   +7 more
semanticscholar   +1 more source

Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste? [PDF]

Sleep Science
Authors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy.
Giselle de Martin Truzzi, Renata Carvalho Cremaschi, Fernando Morgadinho Coelho   +2 more
doaj   +1 more source

Polymorphisms in hypocretin receptors and insomnia

Sleep Science, 2013
Hypocretin system has been described as one of the most important neurotransmission systems involved in the waking process. The system’s lack of function, caused by mutation or neuron death, leads to sharp sleepiness in mammals. It has been proposed that
Lhoyane Moraes Oliveira, Sergio Tufik, Luciano Ribeiro Pinto, Silverio Garbuio, Lia Rita Bittencourt, Mario Pedrazzoli   +5 more
doaj   +1 more source

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study. [PDF]

PLoS ONE, 2015
The proper functioning of the mesolimbic reward system is largely dependent on the neurotransmitter dopamine. Recent evidence suggests that the hypocretin system has significant projections to this reward system.
Armand Mensen, Rositsa Poryazova, Gordana Huegli, Christian R Baumann, Sophie Schwartz, Ramin Khatami   +5 more
doaj   +1 more source

Hypocretins or hyporexins? [PDF]

Nature Medicine, 1998
Lettera
Enzo Nisoli, Michele O. Carruba, Alessandra Valerio, Giuseppe Borsani   +3 more
openaire   +3 more sources

Progressive dopamine and hypocretin deficiencies in Parkinson's disease: is there an impact on sleep and wakefulness?

, 2012
Sleep-wake disturbances are frequent in patients with Parkinson's disease, but prospective controlled electrophysiological studies of sleep in those patients are surprisingly sparse, and the pathophysiology of sleep-wake disturbances in Parkinson's ...
Storch, Alexander, Weller, Michael, Bassetti, C L, Waldvogel, Daniel, Baumann-Vogel, H, Baumann, C R, Bassetti, Claudio L, Storch, A, Wienecke, Miriam, Wienecke, M, Weller, M, Werth, Esther, Baumann-Vogel, Heide, Baumann, Christian R, Poryazova, R, Waldvogel, D, Werth, E; https://orcid.org/, Poryazova, Rositsa   +17 more
core   +1 more source

Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future.

Sleep, 2020
Animal models have advanced not only our understanding of the etiology and phenotype of the sleep disorder narcolepsy but have also informed sleep/wake regulation more generally.
Ryan K. Tisdale, A. Yamanaka, T. Kilduff
semanticscholar   +1 more source

Salivary biomarkers in sleep‐related disorders

Sleep Research, EarlyView.
Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li, Yi Wang, Ying Ni Lin, Jun Qi Lin, Ya Ru Yan, Xian wen Sun, Liu Zhang, Shi Qi Li, Ning Li, Qing Yun Li   +9 more
wiley   +1 more source