Results 21 to 30 of about 12,344 (239)
Editorial: Hypocretins/Orexins
Frontiers in Endocrinology, 2020 Miguel López +4 more
doaj +3 more sources
Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes
Dementia and Geriatric Cognitive Disorders Extra, 2021 Background/Aims: Hypocretin promotes wakefulness and modulates REM sleep. Alterations in the hypocretin system are increasingly implicated in dementia.
Lynn Marie Trotti +4 more
doaj +1 more source
Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice
Communications Biology, 2023 Optogenetic or pharmacological modulation of hypocretin neurons impacts mouse impulsivity in a Go/No-Go task, suggesting that these neurons play a key role in integrating salient stimuli and guiding responses to various environmental cues. Neurons in the
Susan M Tyree +6 more
semanticscholar +1 more source
A direct estrogenic involvement in the expression of human hypocretin
bioRxiv, 2023 Background Hypocretin-1 may play an important role in depression, which was increased in female depression in LHA in our previous study. Estrogen acts through its nuclear transcriptional receptors. Methods We studied the possibility of a direct action of
Hai-Mei Li +7 more
semanticscholar +1 more source
The hypocretins and sleep [PDF]
The FEBS Journal, 2005 The hypocretins (also called the orexins) are two neuropeptides derived from the same precursor whose expression is restricted to a few thousand neurons of the lateral hypothalamus. Two G‐protein coupled receptors for the hypocretins have been identified, and these show different distributions within the central nervous system and differential ...
Luis, de Lecea, J Gregor, Sutcliffe
openaire +2 more sources
Sleep, 2022 STUDY OBJECTIVES The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤110 pg/mL.
A. E. van der Hoeven +7 more
semanticscholar +1 more source
Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]
Encephalitis, 2021 Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
doaj +1 more source
Frontiers in Psychiatry, 2023 IntroductionPosttraumatic stress disorder (PTSD) is a psychiatric disorder developed in individuals who expose to traumatic events. These patients may experience symptoms, such as recurrent unwanted memory of the traumatic event, avoidance of reminders ...
Tung-Yen Lee +6 more
doaj +1 more source
Sleep, 2022 STUDY OBJECTIVE To assess the performances of alternative measures of the multiple sleep latency test (MSLT) to identify hypocretin-deficiency in patients with a complaint of hypersomnolence, including patients with narcolepsy.
R. Lopez +7 more
semanticscholar +1 more source
Narcolepsy Type 1: Should We Only Target Hypocretin Receptor 2?
Clinical and Translational Neuroscience, 2023 Nearly 25 years have passed since the ground-breaking discovery that hypocretin deficiency underlies human narcolepsy with cataplexy. Over time, it has become increasingly evident that hypocretin deficiency goes beyond the conventional core symptoms, or ...
Rolf Fronczek, Gert Jan Lammers
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