Results 21 to 30 of about 8,767 (247)
Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice
Communications Biology, 2023 Optogenetic or pharmacological modulation of hypocretin neurons impacts mouse impulsivity in a Go/No-Go task, suggesting that these neurons play a key role in integrating salient stimuli and guiding responses to various environmental cues. Neurons in the
Susan M Tyree +6 more
semanticscholar +1 more source
Sleep, 2022 STUDY OBJECTIVES The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤110 pg/mL.
A. E. van der Hoeven +7 more
semanticscholar +1 more source
Sleep, 2022 STUDY OBJECTIVE To assess the performances of alternative measures of the multiple sleep latency test (MSLT) to identify hypocretin-deficiency in patients with a complaint of hypersomnolence, including patients with narcolepsy.
R. Lopez +7 more
semanticscholar +1 more source
Frontiers in Psychiatry, 2023 IntroductionPosttraumatic stress disorder (PTSD) is a psychiatric disorder developed in individuals who expose to traumatic events. These patients may experience symptoms, such as recurrent unwanted memory of the traumatic event, avoidance of reminders ...
Tung-Yen Lee +6 more
doaj +1 more source
Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]
Encephalitis, 2021 Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
doaj +1 more source
Progress of autonomic disturbances in narcolepsy type 1
Frontiers in Neurology, 2023 Narcolepsy type 1 is a kind of sleep disorder characterized by a specific loss of hypocretin neurons in the lateral hypothalamus and reduced levels of hypocretin-1 in the cerebrospinal fluid.
Ying Wang +6 more
doaj +1 more source
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Journal of Neuroscience, 1998 The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies in a subregion of the tuberal part of the hypothalamus.
C. Peyron +7 more
semanticscholar +1 more source
Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency.
Monographs in neural sciences, 2021 Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in the disorder, a gateway to understanding REM sleep.
E. Mignot +3 more
semanticscholar +1 more source
Narcolepsy with intermediate cerebrospinal level of hypocretin-1.
Sleep, 2021 STUDY OBJECTIVES To describe the phenotype of narcolepsy with intermediate cerebrospinal hypocretin-1 levels (CSF hcrt-1). METHODS From 1600 consecutive patients with narcolepsy from Bologna and Montpellier sleep centers we selected patients with ...
E. Postiglione +10 more
semanticscholar +1 more source
Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome
Journal of Neuroscience, 2021 We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons. However, it remains unknown how this increase affects target areas
R. McGregor +7 more
semanticscholar +1 more source