Results 111 to 120 of about 549,398 (188)

Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations. [PDF]

Nat Sci Sleep, 2023
Mogavero MP, Silvani A, Lanza G, DelRosso LM, Ferini-Strambi L, Ferri R.   +5 more
europepmc   +1 more source

The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. [PDF]

PLoS One, 2022
Cook C, Nunn N, Worth AA, Bechtold DA, Suter T, Gackeheimer S, Foltz L, Emmerson PJ, Statnick MA, Luckman SM.   +9 more
europepmc   +1 more source

Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behaviour in alcohol-dependent rats. [PDF]

Br J Pharmacol, 2023
Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R.   +6 more
europepmc   +1 more source

Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice

Iranian Journal of Allergy, Asthma and Immunology, 2016
Orexin A and B are hypothalamic peptides with a wide variety of effects such as anti-inflammation and neuroprotection. Impaired function of orexin system has been reported in some neurodegenerative diseases like Parkinson, Huntington and Alzheimer.
Iman Fatemi, Ali Shamsizadeh, Ali Roohbakhsh, Fatemeh Ayoobi, Mohammad Hossein Sanati, Manijeh Motevalian   +5 more
doaj  

Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala. [PDF]

Neuropharmacology, 2022
Yaeger JDW, Krupp KT, Summers TR, Summers CH.   +3 more
europepmc   +1 more source

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

, 2016
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 ...
Annette G. Beck-Sickinger (92957), Richard M. Söll (2724037), Manja Lang (2141818), Frank M. Dautzenberg (2724040), Franz Dürrenberger (2724043)   +4 more
core   +1 more source

In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors. [PDF]

Front Neurosci, 2021
Kim HJJ, Zagzoog A, Smolyakova AM, Ezeaka UC, Benko MJ, Holt T, Laprairie RB.   +6 more
europepmc   +1 more source

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. [PDF]

Nat Commun, 2021
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC.   +14 more
europepmc   +1 more source

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A

, 2007
Presence of appetite-regulating peptides orexin-A and orexin-B in mucosal endocrine cells suggests a role in physiological control of the intestine. Our aim was to characterize orexin-induced stimulation of duodenal bicarbonate secretion and modulation ...
Sjöblom, Markus,, Bengtsson, Magnus W.,, Åkerman, Karl E. O.,, Flemström, Gunnar,, Herzig, Karl-Heinz, Mäkelä, Kari, Uotila, Sanna   +6 more
core   +1 more source

Signaling via Orexin Receptors [Elektronisk resurs] : A Pharmacological Study

, 2004
The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation
Kukkonen, Jyrki, Flemström, Gunnar, Holmqvist, Tomas,, Åkerman, Karl, Svenningsson, Per,   +4 more
core