Results 111 to 120 of about 9,891 (221)

The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases

Frontiers in Molecular Neuroscience, 2018
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin ...
Chunmei Wang, Qinqin Wang, Bingyuan Ji, Yanyou Pan, Chao Xu, Baohua Cheng, Bo Bai, Jing Chen, Jing Chen   +8 more
doaj   +1 more source

Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices. [PDF]

Eur J Pharmacol, 2023
Kostansek JA, Latona GJ, Heruye SH, Matthews S, Bockman CS, Simeone KA, Simeone TA.   +6 more
europepmc   +1 more source

Research progress of narcolepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal.
Fu-long XIAO, Jun ZHANG, Fang HAN
doaj  

A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers

SAGE Open Medicine, 2017
A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples.
Nicole L Graybill, Volkmar Weissig
doaj   +1 more source

Reply to: The G protein preference of orexin receptors is currently an unresolved issue. [PDF]

Nat Commun, 2023
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM.   +15 more
europepmc   +1 more source

Excessive daytime sleepiness and frequent nightmares are associated with suicidal ideation among psychiatric inpatients

Sleep Research, Volume 3, Issue 2, Page 161-169, June 2026.
Abstract Objectives This study aimed to explore the association between excessive daytime sleepiness (EDS) and frequent nightmares and the risk for suicidal ideation (SI) among psychiatric inpatients. Methods In this cross‐sectional study, 650 inpatients were consecutively recruited from the inpatient department of Shantou University Mental Health ...
Pikun Tan, Jun Wu, Yanyuan Dai, Le Chen, Jiansheng Zhang, Ruifan Shao, Chongtao Xu, Baixin Chen, Yun Li   +8 more
wiley   +1 more source

Multiple phospholipase activation by OX(1) orexin/hypocretin receptors

, 2008
We investigated coupling of OX(1) receptors to phospholipase activation and diacylglycerol generation in Chinese hamster ovary (CHO) cells using both biochemical and fluorescence "real-time" methods.
Kukkonen, Jyrki,, Johansson, Lisa,, Ekholm, Marie,   +2 more
core   +1 more source

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after TBI- the orexin/
Rebecca T. Somach, Miranda M. Lim, Akiva S. Cohen   +2 more
doaj   +1 more source

The Orexin receptors: Structural and anti-tumoral properties. [PDF]

Front Endocrinol (Lausanne), 2022
Couvineau A, Nicole P, Gratio V, Voisin T.   +3 more
europepmc   +1 more source

Effects of a newly developed potent orexin-2 receptor-selective antagonist Compound1m on sleep/wake states in mice

Frontiers in Neuroscience, 2014
Orexins (also known as hypocretins), which are hypothalamic neuropeptides, play critical roles in the regulation of sleep/wakefulness states by activating two G-protein coupled receptors (GPCRs), orexin 1 (OX1R) and orexin 2 receptors (OX2R). In order to
Keishi eEtori, Yuki eSaito, Natsuko eTsujino, Takeshi eSakurai   +3 more
doaj   +1 more source