Results 141 to 150 of about 9,891 (221)

A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging. [PDF]

Molecules, 2020
Bai P, Bai S, Placzek MS, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C.   +7 more
europepmc   +1 more source

Structure-guided discovery of orexin receptor-binding PET ligands

Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging of the G protein-coupled orexin receptors OX1R and OX2R
Peter, Gmeiner, Jürgen, Einsiedel, Harald, Hübner, Katharina, Distler, Simone, Maschauer, Eduard, Neu, Olaf, Prante   +6 more
core   +1 more source

Integrative physiology of orexins and orexin receptors.

Integrative physiology of orexins and orexin receptors.
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
openaire  

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus. [PDF]

Sci Rep
Krause GM, Chirich Barreira LM, Albrecht A.   +2 more
europepmc   +1 more source

Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence. [PDF]

Front Integr Neurosci, 2020
Matzeu A, Martin-Fardon R.
europepmc   +1 more source

Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina

, 2017
PURPOSE: Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: OX1R and OX2R. Orexins and orexin receptors are expressed in retinal neurons.
Gong Zhang, Shi-Jun Weng, Xiao-Hua Wu, Guo-Zhong Xu,, Yong-Mei Zhong, Xiong-Li Yang   +5 more
core  

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B. [PDF]

Cell Mol Life Sci
Prischich D, Sortino R, Gomila-Juaneda A, Matera C, Guardiola S, Nepomuceno D, Varese M, Bonaventure P, de Lecea L, Giralt E, Gorostiza P.   +10 more
europepmc   +1 more source

Orexin Receptors in Recombinant CHO Cells : Signaling to Short- and Long-Term Cell Responses

, 2005
Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of
Ammoun, Sylwia
core  

Orexin Receptors in Recombinant CHO Cells [Elektronisk resurs] : Signaling to Short- and Long-Term Cell Responses

, 2005
Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of
Kukkonen, Jyrki, Flemström, Gunnar, Ammoun, Sylwia,, Larsson, Christer,, Åkerman, Karl   +4 more
core