Results 151 to 160 of about 549,398 (188)

Adenosine A₁ and A_2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications. [PDF]

Biomol Ther (Seoul)
Jee HJ, Youn C, Lee H, Jung YS.
europepmc   +1 more source

Wake-promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance. [PDF]

Alzheimers Dement
Pedersen TJ, Clemens SG, Winer JR, Sharma A, Falgàs N, Lucey BP, Gordon BA, Musiek ES.   +7 more
europepmc   +1 more source

Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation. [PDF]

Curr Obes Rep
Yang S, Huang Z, Lu W, Wang W, Wu S, Wang Y, Huang L, Chen L, Chen R, Liang F.   +9 more
europepmc   +1 more source

Suvorexant protects from ocular complications of diabetes in db/db mice. [PDF]

BMJ Open Diabetes Res Care
Sodhi RK, Mahajan N, Abhyankar SD, Bhatwadekar AD.   +3 more
europepmc   +1 more source

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Orexin receptors: Targets and applications

Fundamental & Clinical Pharmacology, 2021
AbstractOver the years, elucidating targets from the neural circuits that can be used to treat disorders pertaining to the nervous system and extending their scope to other systems have always proved interesting to researchers. The role of various peptides and neurotransmitters has been elucidated and is being developed as therapeutic targets.
Subhiksha Subramanian, Mirunalini Ravichandran   +1 more
openaire   +2 more sources

Orexin Receptor Antagonists and Insomnia

Current Psychiatry Reports, 2022
We review recent evidence on the use of orexin receptor antagonists (ORAs) for treating insomnia. We evaluate studies on five dual ORAs and one selective ORA.Research on suvorexant in recent years gradually focus on comorbid insomnia, while lemborexant and daridorexant were still being validated in primary insomnia.
Xin, Wu, Tao, Xue, Zhouqing, Chen, Zhong, Wang, Gang, Chen   +4 more
openaire   +2 more sources

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang, Richard M, Söll, Franz, Dürrenberger, Frank M, Dautzenberg, Annette G, Beck-Sickinger   +4 more
openaire   +2 more sources

Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review

Acta Physiologica, 2010
AbstractAn unexpected and fascinating aspect of the neuropeptides orexins has recently emerged when it was shown that orexins acting at orexin receptors OX1R or OX2R induce dramatic apoptosis resulting in massive reduction in cell growth in various cancer cell lines.
M, Laburthe, T, Voisin, A, El Firar
openaire   +2 more sources