Results 71 to 80 of about 549,398 (188)

Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway

Frontiers in Neuroscience, 2023
BackgroundFocal motor seizures that originate in the motor region are a considerable challenge because of the high risk of permanent motor deficits after resection.
Tao Xue, Shu Wang, Shujun Chen, Huizhi Wang, Chong Liu, Lin Shi, Yutong Bai, Chunkui Zhang, Chunlei Han, Jianguo Zhang, Jianguo Zhang   +10 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Signaling via Orexin Receptors : A Pharmacological Study

, 2004
The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation
Holmqvist, Tomas
core   +2 more sources

Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study

BMC Research Notes, 2022
Objective Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection.
Yasuhiro Ogawa, Nobutake Shimojo, Akiko Ishii, Akira Tamaoka, Satoru Kawano, Yoshiaki Inoue   +5 more
doaj   +1 more source

Use of Dual Orexin Receptor Antagonists for Insomnia and the Risk of Falls and Fractures: A Systematic Review and Meta‐Analysis

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Falls are the leading cause of injury in older adults. Sedative‐hypnotic use is a known risk factor, but their use for insomnia continues to be common. Dual orexin receptor antagonists (DORAs) are a new, potentially safer class of medications for insomnia.
Arianna Paolone, Shehraz Riar, Shajjan Vejayavarnan, Alexandra Papaioannou, George Ioannidis, Justin Lee   +5 more
wiley   +1 more source

Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors [PDF]

Frontiers in Neuroscience, 2013
Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can predict contributing factors such as duration of action and undesirable effects.
Callander, GE, Olorunda, M, Monna, D, Schuepbach, E, Langenegger, D, Betschart, C, Hintermann, S, Behnke, D, Cotesta, S, Fendt, M, Laue, G, Ofner, S, Briard, E, Gee, CE, Jacobson, LH, Hoyer, D   +15 more
openaire   +3 more sources

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann, Raphael J. Dressle, Fee Benz, Kai Spiegelhalder, Anna F. Johann, Christoph Nissen, Elisabeth Hertenstein, Chiara Baglioni, Laura Palagini, Lukas Krone, Michael L. Perlis, Katharina Domschke, Mathias Berger, Bernd Feige   +13 more
wiley   +1 more source

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats [PDF]

, 2008
\ud RATIONALE:\ud \ud Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking.
Stephanie L. Borgland, Pia Steensland, Taha, Sharif, Steensland, Pia, Jeffrey A. Simms, Sharif A. Taha, Selena E. Bartlett, Richards, Jemma, Bonci, Antonello, Bartlett, Selena, Borgland, Stephanie, Jemma K. Richards, Antonello Bonci, Simms, Jeffrey   +13 more
core   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source