Results 11 to 20 of about 549,398 (188)
Frontiers in Behavioral Neuroscience, 2013 Orexins are recently found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress-induced drug seeking remains unknown. The nucleus accumbens shell (NAcSh), best known for its
Keke eQi +4 more
doaj +3 more sources
Orexin receptors in GtoPdb v.2021.3. [PDF]
IUPHAR BPS Guide Pharm CITE, 2021 Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor ...
Coleman P +12 more
europepmc +3 more sources
The Dual Orexin Receptor Antagonist Almorexant Induces Sleep and Decreases Orexin-Induced Locomotion by Blocking Orexin 2 Receptors [PDF]
Sleep, 2012 Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in locomotion and sleep/wake regulation were investigated in mice.Mice ...
Géraldine M, Mang +8 more
openaire +3 more sources
The novel role of the neuropeptides Orexin and QRFP and their involvement in Alzheimer's disease [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University London.Alzheimer’s disease (AD) is a neurodegenerative disease which affects over 500,000 people in the UK.
Davies, Julie
core +7 more sources
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B [PDF]
, 2023 Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy.
Rosalba, Sortino +10 more
core +2 more sources
The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]
PLoS ONE, 2014 This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta +9 more
doaj +1 more source
Experimental Gerontology, 2023 Aging is related to a variety of physiological organ changes, including central and peripheral nervous systems. It has been reported that the orexin signaling has a potential analgesic effect in different models of pain, especially inflammatory pulpal ...
Shima Torkzadeh-Mahani +5 more
doaj +1 more source
Orexins and Their Receptors in the Human Retina [PDF]
Pathobiology, 2004 <i>Objectives:</i> Orexins A and B are neuropeptides involved in the regulation of feeding behavior, energy homeostasis and arousal. In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained.
Savaskan, E +4 more
openaire +3 more sources
Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. [PDF]
PLoS ONE, 2017 Orexin-A and -B are hypothalamic neuropeptides of 33 and 28-amino acids, which regulate many homeostatic systems including sleep/wakefulness states, energy balance, energy homeostasis, reward seeking and drug addiction.
Anne Blais +6 more
doaj +1 more source
Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
openaire +2 more sources