Results 11 to 20 of about 9,891 (221)

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
doaj   +2 more sources

Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference

Frontiers in Behavioral Neuroscience, 2013
Orexins are recently found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress-induced drug seeking remains unknown. The nucleus accumbens shell (NAcSh), best known for its
Keke eQi, Keke eQi, Chuguang eWei, Yonghui eLi, Nan eSui   +4 more
doaj   +2 more sources

In Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor‐Mediated Signaling [PDF]

Pharmacology Research & Perspectives
The co‐expression of different types of G protein‐coupled receptors (GPCRs) in the same cells can have implications for receptor signaling and receptor cross‐talk, potentially altering the apparent potency or efficacy of ligands targeting each receptor ...
Kawthar A. Mohamed, Robert B. Laprairie
doaj   +2 more sources

Merkel cells, a new localization of prepro-orexin and orexin receptors [PDF]

Journal of Anatomy, 2004
AbstractOrexins (OXA and OXB) are peptides derived from a common precursor called prepro‐orexin. They act through G‐protein receptors named orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). Orexins were first demonstrated in neurons of the lateral hypothalamus and found to be related to the control of food intake.
Rosalia Gallego, Tomáš Garcia-Caballero, CARLOS Dieguez   +2 more
exaly   +3 more sources

Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]

Journal of Endocrinology, 2006
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are ...
J E, Digby, J, Chen, J Y, Tang, H, Lehnert, R N, Matthews, H S, Randeva   +5 more
openaire   +3 more sources

The Dual Orexin Receptor Antagonist Almorexant Induces Sleep and Decreases Orexin-Induced Locomotion by Blocking Orexin 2 Receptors [PDF]

Sleep, 2012
Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in locomotion and sleep/wake regulation were investigated in mice.Mice ...
Géraldine M, Mang, Thomas, Dürst, Hugo, Bürki, Stefan, Imobersteg, Dorothee, Abramowski, Edi, Schuepbach, Daniel, Hoyer, Markus, Fendt, Christine E, Gee   +8 more
openaire   +3 more sources

Discovery of Small-Molecule Antagonists of Orexin 1/2 Receptors from Traditional Chinese Medicinal Plants with a Hypnotic Effect

Pharmaceuticals, 2023
Insomnia is an important public health problem. The currently available treatments for insomnia can cause some adverse effects. Orexin receptors 1 (OX1R) and 2 (OX2R) are burgeoning targets for insomnia treatment. It is an effective approach to screening
Jia He, Jing Fang, Yuxin Wang, Chengyu Ge, Shao Liu, Yueping Jiang   +5 more
doaj   +3 more sources

Orexin Receptors: Pharmacology and Therapeutic Opportunities [PDF]

Annual Review of Pharmacology and Toxicology, 2011
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors. In fact, they are necessary for normal wakefulness, as loss of the orexin-producing neurons causes narcolepsy in humans and rodents.
Thomas E, Scammell, Christopher J, Winrow   +1 more
openaire   +3 more sources

Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1. [PDF]

CNS Neurosci Ther
Orexin B/OX2R signaling attenuates cerebral aneurysm formation by suppressing SP‐1‐mediated inflammation, macrophage infiltration, and endothelial adhesion, with OX2R knockdown abolishing these protective effects. The study highlights Orexin B as a therapeutic candidate targeting vascular inflammation and remodeling in aneurysms.
Chen L, Xu J, Ye F, Luo J, Yu H.
europepmc   +2 more sources

Context-Dependent Temporal Changes in Hypnotics Involved in Suicide Attempts. [PDF]

Neuropsychopharmacol Rep
Temporal changes in hypnotics involved in suicide attempts showed context‐dependent shifts. Dual orexin receptor antagonists increased significantly, while benzodiazepine involvement declined only in overdose‐related attempts. Melatonin receptor agonists showed no significant trend during 2020.
Sasaki T, Sugawara N, Furukawa M, Iwaki H, Suda S, Yasui-Furukori N.   +5 more
europepmc   +2 more sources