Results 41 to 50 of about 27,173 (244)

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]

, 2017
BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette, Connor, Kathryn M, Herring, W Joseph, Hutzelmann, Jill, Krystal, Andrew D, Lines, Christopher, Michelson, David, Snavely, Duane, Thase, Michael, Trivedi, Madhukar H   +9 more
core   +1 more source

Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

Frontiers in Neuroscience, 2021
The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models ...
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli   +9 more
doaj   +1 more source

Effects of Orexin A on Thermal Behaviour: Substantial Evidences for Thermoregulatory Role of Orexin A [PDF]

OMICS Journal of Radiology, 2014
Orexin A is a hypothalamic neuropeptide produced in the dorsal and lateral hypothalamus, and orexin-producing cell have widespread anatomical projections within the central nervous system. Orexin A is involved in multiple physiological functions, including eating behavior, thermoregulation, and sleep-regulation.
Viggiano E, Messina G, Viggiano A, Viggiano A, De Luca V, Messina A, MONDA, Marcellino   +6 more
openaire   +2 more sources

Orexin expression in different prostate histopathologic examinations: Can it be a marker for prostate cancer? A preliminary result

Urology Research and Practice, 2019
Objective: The aim of this study was to evaluate the expression of the orexin receptor in different prostate pathologies, including prostate adenocarcinoma, benign prostate hyperplasia and chronic prostatitis.
Murad Mehmet Başar, Ünsal Han, Murat Çakan, Serhan Alpcan, Halil Başar   +4 more
doaj   +1 more source

Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson's disease: A retrospective study.

PLoS ONE, 2022
Patients with Parkinson's disease (PD) often suffer from sleep disturbances, including excessive daytime sleepiness (EDS) and rapid eye movement sleep behavior disorder (RBD).
Takuya Ogawa, Yuta Kajiyama, Hideaki Ishido, Shigeru Chiba, Gajanan S Revankar, Tomohito Nakano, Seira Taniguchi, Takashi Kanbayashi, Kensuke Ikenaka, Hideki Mochizuki   +9 more
doaj   +1 more source

Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle [PDF]

, 2013
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionThe perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated in several physiological functions ...
Garzón, Miguel, Núñez, Ángel, Rodrigo-Angulo, Margarita Lucía, Tortorella, Silvia   +3 more
core   +3 more sources

Genes and primary headaches: discovering new potential therapeutic targets [PDF]

, 2013
Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola, Gai, Annalisa, Gentile, Salvatore, Paemeleire, Koen, Pinessi, Lorenzo, Rainero, Innocenzo, Rubino, Elisa, Sarchielli, Paola, Vacca, Alessandro   +8 more
core   +3 more sources

Animals-assisted therapy: A brief review [PDF]

, 2018
In rehabilitative setting, the presence of animals can be considered as an important stimulus for verbal and social communication, and for mood regulation.
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Gallai B., Geraci D., Giugliano P., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Murabito P., Parisi L., Pennacchio S., Picciocchi E., Romano P., Ruberto M., Russo D., Salerno M., Sorrentino M., Testa D., Tripi G.   +22 more
core   +1 more source

Orexin A Controls Glucose Metabolism [PDF]

Journal of Diabetes & Metabolism, 2014
The orexin-A and orexin-B are a hypothalamic neuropeptides, involved in the regulation of feeding behaviour, sleep-wakefulness rhythm, and neuroendocrine homeostasis that influence the sympathetic nervous system activity, blood pressure regulation, and metabolic status, glycemic, and may contribute to increase diabetics morbidity and mortality.
Messina G, Dalia C, Tafuri D, Palmieri F, Dato A, Russo A, De Blasio S, Messina A, De Luca V, CHIEFFI, Sergio, MONDA, Marcellino   +10 more
openaire   +1 more source

Forensic considerations on violent parasomnias during lifespan [PDF]

, 2018
Nocturnal parasomnias are a group of sleep complex manifestation that don't alter the sleep macrostructure, but when persistent during adulthood may be assume violent aspects with relevant forensic implications about the ...
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Franco S., Gallai B., Geraci D., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Murabito P., Parisi L., Picciocchi E., Polito A. N., Romano P., Russo D., Salerno M., Salerno M., Sessa F., Sorrentino M., Testa D., Tripi G.   +23 more
core   +1 more source