Results 1 to 10 of about 20,500 (161)

The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases

Frontiers in Molecular Neuroscience, 2018
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin ...
Chunmei Wang, Qinqin Wang, Bingyuan Ji, Yanyou Pan, Chao Xu, Baohua Cheng, Bo Bai, Jing Chen, Jing Chen   +8 more
doaj   +3 more sources

Orexin-A increases the differentiation of human olfactory sensory neurons through orexin receptor type 1 [PDF]

Regenerative Therapy
Introduction: Sensorineural olfactory dysfunction significantly impairs the life quality of patients but without effective treatments to date. Orexin is a neurotrophic factor activates neuronal network activity.
Yin-Tzu Chen, Tai-Horng Young, Yu-Hsin Wang, Chih-Hsuan Huang, Yu-Yun Gao, Tsung-Wei Huang   +5 more
doaj   +2 more sources

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity. [PDF]

PLoS ONE, 2017
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties.
Ainoleena Turku, Maiju K Rinne, Gustav Boije Af Gennäs, Henri Xhaard, Dan Lindholm, Jyrki P Kukkonen   +5 more
doaj   +4 more sources

Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins

Journal of Pharmacological Sciences, 2003
Signal transduction pathways of orexin receptors were examined using a nerve-like cell line transfected with orexin receptor type-1 (OX1R) and orexin receptor type-2 (OX2R).
Yun Zhu, Yoshihiro Miwa, Akihiro Yamanaka, Toshihiko Yada, Megumi Shibahara, Yoichiro Abe, Takeshi Sakurai, Katsutoshi Goto   +7 more
doaj   +3 more sources

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates [PDF]

Scientific Reports
Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR).
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard   +7 more
doaj   +2 more sources

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti, AJ Lawrence, Alice Y. W. Chang, AR Di Sebastiano, B Boutrel, B Boutrel, B Wang, BA Baldo, Beáta Á. Borsay, C Baimel, C Peyron, CM Kotz, CS Molnar, Csilla S. Molnár, CV Dayas, D Georgescu, D Sulzer, E Hirsch, E Hrabovszky, E Hrabovszky, Erik Hrabovszky, G Aston-Jones, G Martin, GC Harris, GC Harris, J Fadel, J Xia, JA Hollander, JJ Balcita-Pedicino, K Mukai, L de Lecea, László Herczeg, M Barrot, M Narita, NM Vittoz, NM Vittoz, Péter Gergely, R Fronczek, R Sharf, R Sharf, RM Chemelli, S Deurveilher, S Srinivasan, SL Borgland, SV Mahler, T Bullmann, T Nakamura, T Sakurai, TM Korotkova, TM Korotkova, XY Lu, Y Date, Z Liposits, Zsolt Liposits   +53 more
core   +11 more sources

Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension

Scientific Reports, 2021
Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension.
Rohan Umesh Parekh, Acacia White, Korin E. Leffler, Vinicia C. Biancardi, Jeffrey B. Eells, Abdel A. Abdel-Rahman, Srinivas Sriramula   +6 more
doaj   +1 more source

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
doaj   +1 more source

Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. [PDF]

PLoS ONE, 2013
Both orexin and neurotensin are expressed in the lateral hypothalamic area (LHA) and have been implicated in the regulation of feeding, motor activity and the reward system.
Naoki Furutani, Mari Hondo, Haruaki Kageyama, Natsuko Tsujino, Michihiro Mieda, Masashi Yanagisawa, Seiji Shioda, Takeshi Sakurai   +7 more
doaj   +1 more source

Evolution of Orexin Neuropeptide System: Structure and Function

Frontiers in Neuroscience, 2020
Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
doaj   +1 more source